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The Pathophysiology of Mitochondrial Cell Death This copy is for your personal, non-commercial use only. clicking here.colleagues, clients, or customers by , you can order high-quality copies for yourIf you wish to distribute this article to others here.f
- JULY 2004 629 DOI: 10.1126/science.1099320 , 626 (2004);305 Science
"... In the mitochondrial pathway of apoptosis, caspase activation is closely linked to mitochondrial outer membrane permeabilization (MOMP). Numerous pro-apoptotic signal-transducing molecules and pathological stimuli converge on mitochondria to induce MOMP. The local regulation and execution of MOMP in ..."
Abstract
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Cited by 337 (2 self)
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In the mitochondrial pathway of apoptosis, caspase activation is closely linked to mitochondrial outer membrane permeabilization (MOMP). Numerous pro-apoptotic signal-transducing molecules and pathological stimuli converge on mitochondria to induce MOMP. The local regulation and execution of MOMP
Psychology and neurobiology of simple decisions
- Trends Neurosci
, 2004
"... Patterns of neural firing linked to eye movement decisions show that behavioral decisions are predicted by the differential firing rates of cells coding selected and nonselected stimulus alternatives. These results can be interpreted using models developed in mathematical psychology to model behavi ..."
Abstract
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Cited by 213 (7 self)
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provide a quantitative link between the time-course of behavioral decisions and the growth of stimulus information in neural firing data. The question of how two-alternative decisions are made is an important one for neuroscience and psychology alike because of the pivotal role played by decision making
Pivotal Advance: Phospholipids determine
, 2009
"... net membrane surface charge resulting in differential localization of active Rac1 ..."
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net membrane surface charge resulting in differential localization of active Rac1
CEO Involvement in the Selection of New Board Members: An Empirical Analysis
- Journal of Finance
, 1997
"... We study whether CEO involvement in the selection of new directors influences the nature of appointments to the board. When the CEO serves on the nominating committee or no nominating committee exists, firms appoint fewer independent outside directors and more gray outsiders with conflicts of intere ..."
Abstract
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Cited by 175 (13 self)
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of interest. Stock price reactions to independent director appointments are significantly lower when the CEO is involved in director selection. Our evidence may illuminate a mechanism used by CEOs to reduce pressure from active monitoring, and we find a recent trend of companies removing CEOs from involvement
The active pivot shift: The role of the popliteus muscle
"... Ligament insufficiency due to athletic injury is widely recognized and reported as an etiological factor in knee joint instability. It was recognized that a patient pre-senting with knee joint instability due to past hockey injury to the anterior cruciate liagment, subsequently verified surgically, ..."
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, was able to voluntarily and actively perform the pivot shift maneuver with his knee as a result of his anterolateral rotatory instability. During a subsequent 6 month period, three other patients with similar anterior cruciate deficiencies presented with this same active pivot shift maneuver phenomenon. A
Pivotal role of signal transducer and activator of transcription (Stat
- 4 and Stat6 in the
, 2001
"... Signal transducer and activator of transcription (Stat)4 and Stat6 are transcription factors that provide type 1 and type 2 response, respectively. Here, we explored the role of Stat4 and Stat6 in innate immunity during septic peritonitis. Stat4 �/ � and Stat6 �/ � mice were resistant to the lethali ..."
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Cited by 3 (0 self)
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Signal transducer and activator of transcription (Stat)4 and Stat6 are transcription factors that provide type 1 and type 2 response, respectively. Here, we explored the role of Stat4 and Stat6 in innate immunity during septic peritonitis. Stat4 �/ � and Stat6 �/ � mice were resistant
Diffusion of Being Pivotal and Immoral Outcomes
, 2014
"... Abstract. We study how diffusing being pivotal affects the willingness to support immoral outcomes. Subjects decide about agreeing to kill mice and receiving money versus objecting to kill mice and foregoing the monetary amount. We investigate an exogenous diffusion of being pivotal imposed by organ ..."
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, the likelihood to agree to the killing decreases in subjective perceptions of being pivotal. We then show that many subjects actually have a preference to actively create a situation where being pivotal is diffused. In the Endogenous Diffusion treatment, each subject chooses the probability of killing a mouse
YouPivot: Improving Recall with Contextual Search
"... According to cognitive science literature, human memory is predicated on contextual cues (e.g., room, music) in the environment. During recall tasks, we associate information/activities/objects with contextual cues. However, computer systems do not leverage our natural process of using contextual cu ..."
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Cited by 8 (0 self)
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cues to facilitate recall. We present a new interaction technique, Pivoting, that allows users to search for contextually related activities and find a target piece of information (often not semantically related). A sample motivation for contextual search would be, “what was that website I was looking
Attribute pivots for guiding relevance feedback in image search
- In ICCV
, 2013
"... In interactive image search, a user iteratively refines his results by giving feedback on exemplar images. Active se-lection methods aim to elicit useful feedback, but traditional approaches suffer from expensive selection criteria and cannot predict informativeness reliably due to the impreci-sion ..."
Abstract
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Cited by 8 (2 self)
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-sion of relevance feedback. To address these drawbacks, we propose to actively select “pivot ” exemplars for which feed-back in the form of a visual comparison will most reduce the system’s uncertainty. For example, the system might ask, “Is your target image more or less crowded than this im-age? ” Our approach
Glycine 699 is Pivotal for the Motor Activity of Skeletal Muscle Myosin
"... Abstract. Myosin couples ATP hydrolysis to the translocation of actin filaments to power many forms of cellular motility. A striking feature of the structure of the muscle myosin head domain is a 9-nm long "lever arm" that has been postulated to produce a 5-10-nm power stroke. This motion ..."
Abstract
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Cited by 11 (1 self)
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cysteine residues, SH1 and SH2. Alanine mutagenesis of this glycine (G699A) dramatically alters the motor activity of skeletal muscle myosin, inhibiting the velocity of actin filament movement by>100-fold. Analysis of the defect
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