provision of information and valuable suggestions. DISCLAIMER: Mention of a trademark, warranty, proprietary product or vendor does not constitute a guarantee by the U. S. Department of Agriculture and does not imply approval or recommendation of the product to the exclusion of others that may be suitable. ABBREVIATIONS: HITs (high impact traits), TM (trade mark), R (Registered), HVI (high volume instrumentation),

The Internet presents numerous sources of useful information---telephone directories, product catalogs, stock quotes, weather forecasts, etc. Recently, many systems have been built that automatically gather and manipulate such information on a user's behalf. However, these resources

"Grid" computing has emerged as an important new field, distinguished from conventional distributed computing by its focus on large-scale resource sharing, innovative applications, and, in some cases, high-performance orientation. In this article, we define this new field. First, we review the "Grid problem," which we define as flexible, secure, coordinated resource sharing among dynamic collections of individuals, institutions, and resources---what we refer to as virtual organizations. In such settings, we encounter unique authentication, authorization, resource access, resource discovery, and other challenges. It is this class of problem that is addressed by Grid technologies. Next, we present an extensible and open Grid architecture,inwhich protocols, services, application programming interfaces, and software development kits are categorized according to their roles in enabling resource sharing. We describe requirements that we believe any such mechanisms must satisfy and we discuss the importance of defining a compact set of intergrid protocols to enable interoperability among different Grid systems. Finally, we discuss how Grid technologies relate to other contemporary technologies, including enterprise integration, application service provider, storage service provider, and peer-to-peer computing. We maintain that Grid concepts and technologies complement and have much to contribute to these other approaches.

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In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between DNA, RNA, proteins, and small molecules. As most genetic regulatory networks of interest involve many components connected through interlocking positive and negative feedback loops, an intuitive understanding of their dynamics is hard to obtain. As a consequence, formal methods and computer tools for the modeling and simulation of genetic regulatory networks will be indispensable. This paper reviews formalisms that have been employed in mathematical biology and bioinformatics to describe genetic regulatory systems, in particular directed graphs, Bayesian networks, Boolean networks and their generalizations, ordinary and partial differential equations, qualitative differential equations, stochastic equations, and rule-based formalisms. In addition, the paper discusses how these formalisms have been used in the simulation of the behavior of actual regulatory systems.

This paper gives the main definitions relating to dependability, a generic concept including as special case such attributes as reliability, availability, safety, integrity, maintainability, etc. Security brings in concerns for confidentiality, in addition to availability and integrity. Basic definitions are given first. They are then commented upon, and supplemented by additional definitions, which address the threats to dependability and security (faults, errors, failures), their attributes, and the means for their achievement (fault prevention, fault tolerance, fault removal, fault forecasting). The aim is to explicate a set of general concepts, of relevance across a wide range of situations and, therefore, helping communication and cooperation among a number of scientific and technical communities, including ones that are concentrating on particular types of system, of system failures, or of causes of system failures.

cation is the `pager system'. In order to locate a person a signal is sent out by a central facility that addresses a particular receiver unit (beeper) and produces an audible signal. In addition, it may display a number to which the called-party should phone back (some systems allow a vocal message to be conveyed about the call-back number). It is then up to the recipient to use the conventional telephone system to call-back confirming the signal and determine the required action. Although useful in practice there are still circumstances where it is not ideal. For instance, if the called party does not reply the controller has no idea if they: 1) are in an area where the signal does not penetrate 2) have been completely out of the area for some time 3) have been too busy to reply or 4) have misheard or misread the call-back number. Moreover, in the case where there are a number of people who could respond to a crisis situation, it is not known which one is the nearest to the crisis an

The 4+1 View Model organizes a description of a software architecture using five concurrent views, each of which addresses a specific set of concerns. Architects capture their design decisions in four views and use the fifth view to illustrate and validate them.

In recent years, many new cortical areas have been identified in the macaque monkey. The number of identified connections between areas has increased even more dramatically. We report here on (1) a summary of the layout of cortical areas associated with vision and with other modalities, (2) a computerized database for storing and representing large amounts of information on connectivity patterns, and (3) the application of these data to the analysis of hierarchical organization of the cerebral cortex. Our analysis concentrates on the visual system, which includes 25 neocortical areas that are predominantly or exclusively visual in function, plus an additional 7 areas that we regard as visual-association areas on the basis of their extensive visual inputs. A total of 305 connections among these 32 visual and

Computing devices and applications are now used beyond the desktop, in diverse environments, and this trend toward ubiquitous computing is accelerating. One challenge that remains in this emerging research field is the ability to enhance the behavior of any application by informing it of the context of its use. By context, we refer to any information that characterizes a situation related to the interaction between humans, applications and the surrounding environment. Context-aware applications promise richer and easier interaction, but the current state of research in this field is still far removed from that vision. This is due to three main problems: (1) the notion of context is still ill defined; (2) there is a lack of conceptual models and methods to help drive the design of context-aware applications; and (3) no tools are available to jump-start the development of context-aware applications. In this paper, we address these three problems in turn. We first define context, identify categories of contextual information, and characterize context-aware application behavior. Though the full impact of context-aware computing requires understanding very subtle and high-level notions of context, we are focusing our efforts on the pieces of context that can be inferred automatically from sensors in a physical environment. We then present a conceptual framework that separates the acquisition and representation of context from the delivery and reaction to context by a contextaware application. We have built a toolkit, the Context Toolkit, that instantiates this conceptual framework and supports the rapid development of a rich space of context-aware applications. We illustrate the usefulness of the conceptual framework by describing a number of contextaware applications that h...