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From genomics to chemical genomics: new developments in KEGG

by Minoru Kanehisa, Susumu Goto, Masahiro Hattori, Kiyoko F. Aoki-kinoshita, Masumi Itoh, Shuichi Kawashima, Toshiaki Katayama, Michihiro Araki, Mika Hirakawa - Nucleic Acids Res , 2006
"... The increasing amount of genomic and molecular information is the basis for understanding higherorder biological systems, such as the cell and the 15 organism, and their interactions with the environment, as well as for medical, industrial and other practical applications. The KEGG resource ..."
Abstract - Cited by 529 (30 self) - Add to MetaCart
The increasing amount of genomic and molecular information is the basis for understanding higherorder biological systems, such as the cell and the 15 organism, and their interactions with the environment, as well as for medical, industrial and other practical applications. The KEGG resource

Hierarchical Models of Object Recognition in Cortex

by Maximilian Riesenhuber, Tomaso Poggio , 1999
"... The classical model of visual processing in cortex is a hierarchy of increasingly sophisticated representations, extending in a natural way the model of simple to complex cells of Hubel and Wiesel. Somewhat surprisingly, little quantitative modeling has been done in the last 15 years to explore th ..."
Abstract - Cited by 836 (84 self) - Add to MetaCart
The classical model of visual processing in cortex is a hierarchy of increasingly sophisticated representations, extending in a natural way the model of simple to complex cells of Hubel and Wiesel. Somewhat surprisingly, little quantitative modeling has been done in the last 15 years to explore

Using Bayesian networks to analyze expression data

by Nir Friedman, Michal Linial, Iftach Nachman - Journal of Computational Biology , 2000
"... DNA hybridization arrays simultaneously measure the expression level for thousands of genes. These measurements provide a “snapshot ” of transcription levels within the cell. A major challenge in computational biology is to uncover, from such measurements, gene/protein interactions and key biologica ..."
Abstract - Cited by 1088 (17 self) - Add to MetaCart
DNA hybridization arrays simultaneously measure the expression level for thousands of genes. These measurements provide a “snapshot ” of transcription levels within the cell. A major challenge in computational biology is to uncover, from such measurements, gene/protein interactions and key

Tandem repeats finder: a program to analyze DNA sequences

by Gary Benson , 1999
"... A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of regulatory and evolutionary roles and are important laboratory and analytic tools. Extensive knowledge about pattern size, co ..."
Abstract - Cited by 961 (9 self) - Add to MetaCart
, copy number, mutational history, etc. for tandem repeats has been limited by the inability to easily detect them in genomic sequence data. In this paper, we present a new algorithm for finding tandem repeats which works without the need to specify either the pattern or pattern size. We model tandem

The "Independent Components" of Natural Scenes are Edge Filters

by Anthony J. Bell, Terrence J. Sejnowski , 1997
"... It has previously been suggested that neurons with line and edge selectivities found in primary visual cortex of cats and monkeys form a sparse, distributed representation of natural scenes, and it has been reasoned that such responses should emerge from an unsupervised learning algorithm that attem ..."
Abstract - Cited by 617 (29 self) - Add to MetaCart
that attempts to find a factorial code of independent visual features. We show here that a new unsupervised learning algorithm based on information maximization, a nonlinear "infomax" network, when applied to an ensemble of natural scenes produces sets of visual filters that are localized and oriented

Taming the Underlying Challenges of Reliable Multihop Routing in Sensor Networks

by Alec Woo, Terence Tong, David Culler - In SenSys , 2003
"... The dynamic and lossy nature of wireless communication poses major challenges to reliable, self-organizing multihop networks. These non-ideal characteristics are more problematic with the primitive, low-power radio transceivers found in sensor networks, and raise new issues that routing protocols mu ..."
Abstract - Cited by 781 (20 self) - Add to MetaCart
The dynamic and lossy nature of wireless communication poses major challenges to reliable, self-organizing multihop networks. These non-ideal characteristics are more problematic with the primitive, low-power radio transceivers found in sensor networks, and raise new issues that routing protocols

The pyramid match kernel: Discriminative classification with sets of image features

by Kristen Grauman, Trevor Darrell - IN ICCV , 2005
"... Discriminative learning is challenging when examples are sets of features, and the sets vary in cardinality and lack any sort of meaningful ordering. Kernel-based classification methods can learn complex decision boundaries, but a kernel over unordered set inputs must somehow solve for correspondenc ..."
Abstract - Cited by 544 (29 self) - Add to MetaCart
for correspondences – generally a computationally expensive task that becomes impractical for large set sizes. We present a new fast kernel function which maps unordered feature sets to multi-resolution histograms and computes a weighted histogram intersection in this space. This “pyramid match” computation is linear

Support Vector Machine Classification and Validation of Cancer Tissue Samples Using Microarray Expression Data

by Terrence S. Furey, Nello Cristianini, Nigel Duffy, David W. Bednarski, Michèl Schummer, David Haussler , 2000
"... Motivation: DNA microarray experiments generating thousands of gene expression measurements, are being used to gather information from tissue and cell samples regarding gene expression differences that will be useful in diagnosing disease. We have developed a new method to analyse this kind of data ..."
Abstract - Cited by 569 (1 self) - Add to MetaCart
Motivation: DNA microarray experiments generating thousands of gene expression measurements, are being used to gather information from tissue and cell samples regarding gene expression differences that will be useful in diagnosing disease. We have developed a new method to analyse this kind of data

Tor: The secondgeneration onion router,”

by Roger Dingledine - in 13th USENIX Security Symposium. Usenix, , 2004
"... Abstract We present Tor, a circuit-based low-latency anonymous communication service. This second-generation Onion Routing system addresses limitations in the original design by adding perfect forward secrecy, congestion control, directory servers, integrity checking, configurable exit policies, an ..."
Abstract - Cited by 1229 (33 self) - Add to MetaCart
, and instant messaging. Clients choose a path through the network and build a circuit, in which each node (or "onion router" or "OR") in the path knows its predecessor and successor, but no other nodes in the circuit. Traffic flows down the circuit in fixed-size cells, which are unwrapped

A new and rapid colorimetric determination of acetylcholinesterase activity

by George L. Ellman, K. Diane Courtney, Valentino Andres, Robert M. Featherstone - Biochem Pharmacol
"... Abstract-A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described. The enzyme activity is measured by following the increase of yellow color produced from thiocholine when it reacts with dithiobisnitrobenzoate ion. ..."
Abstract - Cited by 450 (0 self) - Add to MetaCart
Abstract-A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described. The enzyme activity is measured by following the increase of yellow color produced from thiocholine when it reacts with dithiobisnitrobenzoate ion
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