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Results 1 - 10
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1,623
Metabolic stability and epigenesis in randomly connected nets
- Journal of Theoretical Biology
, 1969
"... “The world is either the effect of cause or chance. If the latter, it is a world for all that, that is to say, it is a regular and beautiful structure.” Marcus Aurelius Proto-organisms probably were randomly aggregated nets of chemical reactions. The hypothesis that contemporary organisms are also r ..."
Abstract
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Cited by 657 (5 self)
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: behave with great order and stability; undergo behavior cycles whose length predicts cell replication time as a function of the number of genes per cell; possess different modes of behavior whose number per net predicts roughly the number of cell types in an organism as a function of its number of genes
Error and attack tolerance of complex networks
, 2000
"... Many complex systems display a surprising degree of tolerance against errors. For example, relatively simple organisms grow, persist and reproduce despite drastic pharmaceutical or environmental interventions, an error tolerance attributed to the robustness of the underlying metabolic network [1]. C ..."
Abstract
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Cited by 1013 (7 self)
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Many complex systems display a surprising degree of tolerance against errors. For example, relatively simple organisms grow, persist and reproduce despite drastic pharmaceutical or environmental interventions, an error tolerance attributed to the robustness of the underlying metabolic network [1
Specificity and stability in topology of protein networks
- Science
, 2002
"... Molecular networks guide the biochemistry of a living cell on multiple levels: its metabolic and signalling pathways are shaped by the network of interacting proteins, whose production, in turn, is controlled by the genetic regulatory network. To address topological properties of these two networks ..."
Abstract
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Cited by 408 (3 self)
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Molecular networks guide the biochemistry of a living cell on multiple levels: its metabolic and signalling pathways are shaped by the network of interacting proteins, whose production, in turn, is controlled by the genetic regulatory network. To address topological properties of these two networks
A Probabilistic Approach to Classifying Metabolic Stability
, 2008
"... Metabolic stability is an important property of drug molecules that should— optimally—be taken into account early on in the drug design process. Along with numerous medium or high throughput assays being implemented in early drug discovery, a prediction tool for this property could be of high value. ..."
Abstract
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Cited by 1 (0 self)
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Metabolic stability is an important property of drug molecules that should— optimally—be taken into account early on in the drug design process. Along with numerous medium or high throughput assays being implemented in early drug discovery, a prediction tool for this property could be of high value
in Metabolic Stabilization of Tumor Suppressor p53 during Cellular Transformation
, 1995
"... Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation. ..."
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Cited by 6 (0 self)
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Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation.
The Metabolic Stability of Carbohydrates in Walls of Hyphae of Aspergillus clavatus
, 1970
"... The metabolic stability of carbohydrates in walls of hyphae of Aspergillus clavatus was investigated through measurements of mycelial isotope distribu-tion from [U14C]glucose and the,H/14C ratios of re-isolated monosaccharides, when the organism was grown on labelled glucose as sole carbon source. T ..."
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The metabolic stability of carbohydrates in walls of hyphae of Aspergillus clavatus was investigated through measurements of mycelial isotope distribu-tion from [U14C]glucose and the,H/14C ratios of re-isolated monosaccharides, when the organism was grown on labelled glucose as sole carbon source
Metabolic stabilization of muscle nicotinic acetylcholine receptor by rapsyn
- J Neurosci
, 1999
"... Although the metabolic half-life of muscle endplate acetylcholine receptor (AChR) changes during development and after denervation in the adult, little is known about the molecular mechanisms that influence receptor stability. We have investigated the effect on AChR turnover of its interaction with ..."
Abstract
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Cited by 8 (0 self)
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Although the metabolic half-life of muscle endplate acetylcholine receptor (AChR) changes during development and after denervation in the adult, little is known about the molecular mechanisms that influence receptor stability. We have investigated the effect on AChR turnover of its interaction
Metabolic Stability and Antigenic Modulation of Nicotinic Acetylcholine Receptors
"... Abstract. Bovine adrenal chromaftin ceils have nicotinic acetylcholine receptors (AChRs) that are activated by the splanchnic nerve, resulting in release of catecholamines from the cells. Examination of the AChRs can provide information about the regulation and turnover of synaptic components on neu ..."
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on neurons and endocrine cells. Previous studies have shown that mAb 35 recognizes the AChR on the cells. Here we show that mAb 35 can remove AChRs from the surface of the cells by antigenic modulation, and that the modulation can be used together with other methods to examine the stability and turnover
Metabolic stabilization of acetylcholine receptors in vertebrate neuromuscular junctions by muscle activity
- J. Cell
, 1990
"... Abstract. The effects of muscle activity on the growth of synaptic acetylcholine receptor (AChR) accumulations and on the metabolic AChR stability were investigated in rat skeletal muscle. Ectopic end plates induced surgically in adult soleus muscle were denervated early during development when junc ..."
Abstract
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Cited by 3 (0 self)
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Abstract. The effects of muscle activity on the growth of synaptic acetylcholine receptor (AChR) accumulations and on the metabolic AChR stability were investigated in rat skeletal muscle. Ectopic end plates induced surgically in adult soleus muscle were denervated early during development when
RESEARCH ARTICLES Metabolic Stability of Glutaraldehyde Cross-Linked Peptide
, 1999
"... Abstract 0 The stability of peptide DNA condensates was examined after introducing glutaraldehyde to cross-link surface amine groups. A 20 amino acid peptide (CWK18) was used to condense DNA into small (70 nm) condensates. The reaction between glutaraldehyde and peptide DNA condensates was indirectl ..."
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Abstract 0 The stability of peptide DNA condensates was examined after introducing glutaraldehyde to cross-link surface amine groups. A 20 amino acid peptide (CWK18) was used to condense DNA into small (70 nm) condensates. The reaction between glutaraldehyde and peptide DNA condensates
Results 1 - 10
of
1,623
