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Impulses and Physiological States in Theoretical Models of Nerve Membrane

by Richard Fitzhugh - Biophysical Journal , 1961
"... ABSTRACT Van der Pol's equation for a relaxation oscillator is generalized by the addition of terms to produce a pair of non-linear differential equations with either a stable singular point or a limit cycle. The resulting "BVP model " has two variables of state, representing excitabi ..."
Abstract - Cited by 505 (0 self) - Add to MetaCart
ABSTRACT Van der Pol's equation for a relaxation oscillator is generalized by the addition of terms to produce a pair of non-linear differential equations with either a stable singular point or a limit cycle. The resulting "BVP model " has two variables of state, representing

Membranes at Quantum Criticality

by Petr Horava , 2009
"... We propose a quantum theory of membranes designed such that the ground-state wavefunction of the membrane with compact spatial topology Σh reproduces the partition function of the bosonic string on worldsheet Σh. The construction involves worldvolume matter at quantum criticality, described in the ..."
Abstract - Cited by 106 (0 self) - Add to MetaCart
We propose a quantum theory of membranes designed such that the ground-state wavefunction of the membrane with compact spatial topology Σh reproduces the partition function of the bosonic string on worldsheet Σh. The construction involves worldvolume matter at quantum criticality, described

MEMBRANES

by Rubén Cordero, Efraín Rojas , 2000
"... We develop the dynamics of the chiral superconducting membranes in a geometric approach either making a Lagrangian description and a Hamiltonian point of view. Besides, we show the equivalence of the resulting descriptions to the one known Dirac-Nambu-Goto (DNG) case. Integrability for chiral string ..."
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We develop the dynamics of the chiral superconducting membranes in a geometric approach either making a Lagrangian description and a Hamiltonian point of view. Besides, we show the equivalence of the resulting descriptions to the one known Dirac-Nambu-Goto (DNG) case. Integrability for chiral

The dual effect of membrane potential on sodium conductance in the giant axon of Loligo

by A. L. Hodgkin, A. F. Huxley - J. Physiol. London , 1952
"... This paper contains a further account of the electrical properties of the giant axon of Loligo. It deals with the 'inactivation ' process which gradually reduces sodium permeability after it has undergone the initial rise associated with depolarization. Experiments described previously (Ho ..."
Abstract - Cited by 114 (0 self) - Add to MetaCart
(Hodgkin & Huxley, 1952a, b) show that the sodium conductance always declines from its initial maximum, but they leave a number of important points unresolved. Thus they give no information about the rate at which repolarization restores the ability of the membrane to respond with its characteristic

Quantum Field Theory of Many-Body Systems

by Xiao-gang Wen , 2004
"... condensation Extended objects, such as strings and membranes, have been studied for many years in the context of sta-tistical physics. In these systems, quantum effects are typically negligible, and the extended objects can be treated classically. Yet it is natural to wonder how strings and membrane ..."
Abstract - Cited by 155 (4 self) - Add to MetaCart
condensation Extended objects, such as strings and membranes, have been studied for many years in the context of sta-tistical physics. In these systems, quantum effects are typically negligible, and the extended objects can be treated classically. Yet it is natural to wonder how strings

Key Points

by Kim E. Nichols, Claudio G. Giraudo, Monoallelic Stxbp Mutations
"... Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion ..."
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Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.

by Toshihide Kobayashi , Marie-Hélène Beuchat , Margaret Lindsay , Sonia Frias , Richard D Palmiter , Hitoshi Sakuraba , Robert G Parton , Jean Gruenberg - Nat. Cell Biol. , 1999
"... The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Here we report that late endosomes have a pivotal role in intracellular cholesterol transport. We find that in the genetic disease Niemann-Pick type C (NPC), and in drug-treated cells that mimic NPC ..."
Abstract - Cited by 83 (11 self) - Add to MetaCart
NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired. Our results show that the characteristic network of lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a

Membranes on an Orbifold

by Neil Lambert, David Tong , 2008
"... We harvest clues to aid with the interpretation of the recently discovered N = 8 supersymmetric Chern-Simons theory with SO(4) gauge symmetry. The theory is argued to describe two membranes moving in the orbifold R 8 /Z2. At level k = 1 and k = 2, the classical moduli space M coincides with the infr ..."
Abstract - Cited by 28 (1 self) - Add to MetaCart
We harvest clues to aid with the interpretation of the recently discovered N = 8 supersymmetric Chern-Simons theory with SO(4) gauge symmetry. The theory is argued to describe two membranes moving in the orbifold R 8 /Z2. At level k = 1 and k = 2, the classical moduli space M coincides

Specializations in filopodial membranes at points of attachment to the substrate

by John M Robinson, Morris J Karnovsky - J. Cell , 1980
"... ABSTRACT A mouse cell line (LM), which grows predominantly as spindle-shaped cells with numerous filopodia, was employed in this study. These filopodial projections appear to be important as sites of attachment to the substratum in LM cells. Morphologically the filopodia are slender projections from ..."
Abstract - Cited by 5 (0 self) - Add to MetaCart
with the filopodial footpad, implying a difference in the cholesterol content in these regions (filipin-sterol complexes in footpad < cell body). These data suggest a structural and functional specialization of the filopodial-footpad plasma membrane which may be related to cell adhesion. Many cultured cells have

Point Inoculation of Cultivated Tracheal Mucous Membrane with Bacteria

by unknown authors
"... A broad mucous surface (2 X 30 mm) of rabbit trachea was maintained on a solid agar surface for five days by embedment of a tracheal fragment on hard agar in L-15 medium. After cultivation of the membrane for one day, a constant quantity of bacteria was point inoculated onto the mucous membrane with ..."
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A broad mucous surface (2 X 30 mm) of rabbit trachea was maintained on a solid agar surface for five days by embedment of a tracheal fragment on hard agar in L-15 medium. After cultivation of the membrane for one day, a constant quantity of bacteria was point inoculated onto the mucous membrane
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