Results 1 - 10
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A Network of Local and Redundant Gene Regulation Governs Arabidopsis Seed Maturation
"... [LEC1], and LEC2) control most aspects of seed maturation, such as accumulation of storage compounds, cotyledon identity, acquisition of desiccation tolerance, and dormancy. The molecular basis for complex genetic interactions among these regulators is poorly understood. By analyzing ABI3 and FUS3 e ..."
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lec2 phenotypes can be rescued by ABI3 or FUS3 constitutive expression. In addition, ABI3 and FUS3 positively regulate themselves and each other, thereby forming feedback loops essential for their sustained and uniform expression in the embryo. Finally, LEC1 also positively regulates ABI3 and FUS3
Requirement of the Lec35 Gene for All Known Classes of Monosaccharide-P-Dolichol-dependent Glycosyltransferase Reactions in Mammals
, 2000
"... The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively. The h ..."
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. The hamster Lec35 gene is shown to encode the previously identified cDNA SL15, which corrects the Lec35 mutant phenotype and predicts a novel endoplasmic reticulum membrane protein. The mutant hamster alleles Lec35.1 and Lec35.2 are characterized, and the human Lec35 gene (mannose-P-dolichol utilization
Leafy Cotyledon Mutants of Arabidopsis
"... We have previously described a homeotic leafy cotyledon (lec) mutant of Arabidopsis that exhibits striking defects in embryonic maturation and produces viviparous embryos with cotyledons that are partially transformed into leaves. In this study, we present further details on the developmental anatom ..."
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Cited by 11 (1 self)
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for embryonic maturation in Arabidopsis. Three other mutants that produce trichomes on cotyledons following precocious germination in culture are described. One mutant is allelic to lecl, another is a fusca mutant (fusg, and the third defines a new locus (lec2). Mutant embryos differ in morphology, desiccation
Differential Gene Expression of Primary Cultured Lymphatic and
"... Blood vascular endothelial cells (BECs) and the de-velopmentally related lymphatic endothelial cells (LECs) create complementary, yet distinct vascular networks. Each endothelial cell type interacts with flowing fluid and circulating cells, yet each vascular system has evolved specialized gene expre ..."
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expression programs and thus both cell types display different phenotypes. BECs and LECs express distinct genes that are unique to their specific vascular microenviron-ment. Tumors also take advantage of the molecules that are expressed in these vascular systems to enhance their metastatic potential. We
unknown title
"... Cataract, defined as an opacity of the lens or lens cap-sule, is the most common cause of visual impairment in dogs and humans [1,2]. Phacoemulsification extracapsular cataract extraction with intraocular lens (IOL) implantation is the most frequently performed ophthalmic surgical procedure in vet-e ..."
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lens epithelial cells (LEC) is to undergo epithelial-mesenchymal transition (EMT)-like changes [5-7]. This re-sults in posterior migration and proliferation of the LEC with subsequent vision impairment. EMT refers to a change in phe-notype from an epithelial to fibrocytic morphology accompa-
Suppressors of a(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant
, 2004
"... Factors that regulate a(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor meta-stasis. FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2. ..."
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was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase. When
Class I BASIC PENTACYSTEINE factors regulate HOMEOBOX genes involved in meristem size maintenance
"... The BASIC PENTACYSTEINE (BCP) family is a poorly characterized plant transcription factor family of GAGA BINDING PROTEINS. In Arabidopsis, there are seven members (BPC1–7) that are broadly expressed, and they can potentially bind more than 3000 Arabidopsis GAGA-repeat-containing genes. To date, BPCs ..."
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, BPCs are known to be direct regulators of the INNER NO OUTER (INO), SEEDSTICK (STK), and LEAFY COTYLEDON 2 (LEC2) genes. Because of the high functional redundancy, neither single knockout nor double bpc mutant combinations cause aberrant phenotypes. The bpc1-2 bpc2 bpc3 triple mutant shows several
unknown title
"... Corneal stem cells (SCs) are located at the sclerocorneal limbus in the palisades of Vogt, which are highly pigmented structures with an abundance of melanocytes, antigen-presenting cells, and lymphocytes [1,2]. These cells, termed limbal epithelial crypts (LECs), are situated in an anatomi-cally de ..."
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Corneal stem cells (SCs) are located at the sclerocorneal limbus in the palisades of Vogt, which are highly pigmented structures with an abundance of melanocytes, antigen-presenting cells, and lymphocytes [1,2]. These cells, termed limbal epithelial crypts (LECs), are situated in an anatomi-cally
unknown title
"... Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell–derived vascular progenitor cells into endothelial cells Hiroyuki Suzuki, Tetsuro Watabe, Mitsuyasu Kato, Keiji Miyazawa, and Kohei Miyazono Vascular endothelial growth factor recep-tor 2 ..."
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endothelial cells (LECs). To elucidate the roles of VEGFR3 signaling in the differentiation of vascular progenitor cells into ECs, we introduced various types of VEGFR3 cDNAs into mouse ES cells. VEGF-C, a ligand for VEGFR2 and VEGFR3, stimulated the en-dothelial differentiation of the VEGFR2 cells
Evidence for SH2 Domain-Containing 59-Inositol Phosphatase-2 (SHIP2) Contributing to a Lymphatic
"... The lymphatic vasculature plays a critical role in a number of disease conditions of increasing prevalence, such as autoimmune disorders, obesity, blood vascular diseases, and cancer metastases. Yet, unlike the blood vasculature, the tools available to interrogate the molecular basis of lymphatic dy ..."
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with lymphatic dysfunction in humans. Using near-infrared fluorescence lymphatic imaging (NIRFLI) to phenotype and next generation sequencing (NGS) for unbiased genetic discovery in a family with non-syndromic lymphatic disease, we discovered a rare, novel mutation in INPPL1 that encodes the protein SHIP2, which
Results 1 - 10
of
16