Results 1 - 10 of 15,786

Tyrosine phosphorylation and src family kinases control keratinocyte cell–cell adhesion

by Enzo Calautti, Sara Cabodi, Paul L. Stein, Mechthild Hatzfeld, Nancy Kedersha, G. Paolo Dotto - J. Cell Biol , 1998
"... Abstract. In their progression from the basal to upper differentiated layers of the epidermis, keratinocytes undergo significant structural changes, including establishment of close intercellular contacts. An important but so far unexplored question is how these early structural events are related t ..."
Abstract - Cited by 22 (1 self) - Add to MetaCart
to the biochemical pathways that trigger differentiation. We show here that �-catenin, �-catenin/plakoglobin, and p120-Cas are all significantly tyrosine phosphorylated in primary mouse keratinocytes induced to differentiate by calcium, with a time course similar to that of cell junction formation. Together

JCB Article

by Enzo Calautti, Maddalena Grossi, Cristina Mammucari, Yumi Aoyama, Maria Pirro, Yoshitaka Ono, Jie Li, G. Paolo Dotto
"... Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell–cell adhesion ..."
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Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell–cell adhesion

The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion

by Ruud H. Brakenhoff, Martijn Gerretsen, Mirjam Van Dijk, Huib Van Essen, Danislde Weghuis, Richard J. Sinke, Gordon B. Snow, Human Genetics , 1995
"... Abstract. The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man. To anticipate the effect of high antib ..."
Abstract - Cited by 14 (0 self) - Add to MetaCart
Abstract. The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man. To anticipate the effect of high

Rho GTPases and the actin cytoskeleton

by Alan Hall - Science , 1998
"... The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the b ..."
Abstract - Cited by 615 (4 self) - Add to MetaCart
The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding

Vascular permeability factor (vascular endothelial growth factor gene is expressed differentially in normal tissues, macrophages and tumors

by F. Brown, Kiangteck Yeo, Brygida Berse, Tet-kin Yeo, Donald R Senger, Harold F. Dvorak, Livingston Van De - MA BiA Cell. 3:211 , 1992
"... Persistent microvascular hyperpermeability to plasma proteins even after the cessation of injury is a characteristic but poorly understood feature of normal wound healing. It results in extravasation of fibrinogen that clots to form fibrin, which serves as a provisional matrix and promotes angiogene ..."
Abstract - Cited by 367 (9 self) - Add to MetaCart
, initially those at the wound edge, and, at later intervals, keratinocytes that migrated to cover the wound surface; occasional mononuclear cells also expressed VPF mRNA. Secreted VPF was detected by immunofluoroassay of medium from

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

by Magdalena Chrzanowska-wodnicka, Keith Burridge - J. Cell Biol , 1996
"... Abstract. Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, A.J., and A. Hall, 1992. Cell. 70:389-399). The pathway by which rho triggers these events has not been elucidated. Many ..."
Abstract - Cited by 309 (5 self) - Add to MetaCart
Abstract. Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, A.J., and A. Hall, 1992. Cell. 70:389-399). The pathway by which rho triggers these events has not been elucidated. Many

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins. Cell 65:859

by Michael B. Lawrence, Timothy A. Springer , 1991
"... Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named PADGEM and GMP-140 that is in-ducible on endothelial cells. Neutrophils roll on this selectin under flow condit ..."
Abstract - Cited by 284 (14 self) - Add to MetaCart
Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named PADGEM and GMP-140 that is in-ducible on endothelial cells. Neutrophils roll on this selectin under flow

keratinocytes: consequences

by Kevin J. Hamill, Sho Hiroyasu, Zachary T. Colburn, Rosa V. Ventrella, Susan B, Omar Skalli, Jonathan C. R. Jones
"... actinin-1 regulates cell-matrix adhesion organization in ..."
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actinin-1 regulates cell-matrix adhesion organization in

Rho GTPases control polarity, protrusion, and adhesion during cell movement

by Catherine D. Nobes, Alan Hall - J. Cell , 1999
"... Abstract. Cell movement is essential during embryogenesis to establish tissue patterns and to drive morphogenetic pathways and in the adult for tissue repair and to direct cells to sites of infection. Animal cells move by crawling and the driving force is derived primarily from the coordinated assem ..."
Abstract - Cited by 200 (5 self) - Add to MetaCart
Abstract. Cell movement is essential during embryogenesis to establish tissue patterns and to drive morphogenetic pathways and in the adult for tissue repair and to direct cells to sites of infection. Animal cells move by crawling and the driving force is derived primarily from the coordinated

Keratinocyte

by unknown authors
"... Communication between cells of the corpus luteum (CL) is thought to be necessary for normal luteal function. Keratinocyte growth factor (KGF) is produced by mesenchymally derived cells in numerous tissues and acts on epithelial cells. In bovine fol-licles, theca cells produce KGF, which can stimulat ..."
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Communication between cells of the corpus luteum (CL) is thought to be necessary for normal luteal function. Keratinocyte growth factor (KGF) is produced by mesenchymally derived cells in numerous tissues and acts on epithelial cells. In bovine fol-licles, theca cells produce KGF, which can
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