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Results 1 - 10
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9,167
Specificity and mechanism of action of some commonly used protein kinase inhibitors
- Biochem. J
, 2000
"... The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine� threonine-specific protein kinases have been examined against a large panel of protein kinases. The compounds KT 5720, Rottlerin and quercetin were found to inhibit many prot ..."
Abstract
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Cited by 532 (1 self)
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protein kinases, sometimes much more potently than their presumed targets, and conclusions drawn from their use in cell-based experiments are likely to be erroneous. Ro 318220 and related bisindoylmaleimides, as well as H89, HA1077 and Y 27632, were more selective inhibitors, but still inhibited two
Loopy belief propagation for approximate inference: An empirical study. In:
- Proceedings of Uncertainty in AI,
, 1999
"... Abstract Recently, researchers have demonstrated that "loopy belief propagation" -the use of Pearl's polytree algorithm in a Bayesian network with loops -can perform well in the context of error-correcting codes. The most dramatic instance of this is the near Shannon-limit performanc ..."
Abstract
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Cited by 676 (15 self)
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and ap proximately 4000 findin nodes, with a number of ob served findings that varies per case. Due to the form of the noisy-or CPTs the complexity of inference is ex ponential in the number of positive findings Results Initial experiments The experimental protocol for the PYRAMID network was as follows
On the time course of perceptual choice: the leaky competing accumulator model
- PSYCHOLOGICAL REVIEW
, 2001
"... The time course of perceptual choice is discussed in a model based on gradual and stochastic accumulation of information in non-linear decision units with leakage (or decay of activation) and competition through lateral inhibition. In special cases, the model becomes equivalent to a classical diffus ..."
Abstract
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Cited by 480 (19 self)
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The time course of perceptual choice is discussed in a model based on gradual and stochastic accumulation of information in non-linear decision units with leakage (or decay of activation) and competition through lateral inhibition. In special cases, the model becomes equivalent to a classical
Ego depletion: is the active self a limited resource
- Journal of Personality and Social Psychology
, 1998
"... Choice, active response, self-regulation, and other volition may all draw on a common inner resource. In Experiment 1, people who forced themselves to eat radishes instead of tempting chocolates subsequently quit faster on unsolvable puzzles than people who had not had to exert self-control over eat ..."
Abstract
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Cited by 410 (13 self)
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Choice, active response, self-regulation, and other volition may all draw on a common inner resource. In Experiment 1, people who forced themselves to eat radishes instead of tempting chocolates subsequently quit faster on unsolvable puzzles than people who had not had to exert self-control over
Inhibiting and facilitating conditions of the human smile: A nonobtrusive test of the facial feedback hypothesis.
- Journal of Personality and Social Psychology,
, 1988
"... We investigated the hypothesis that people's facial activity influences their affective responses. Two studies were designed to both eliminate methodological problems of earlier experiments and clarify theoretical ambiguities, This was achieved by having subjects hold a pen in their mouth in w ..."
Abstract
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Cited by 241 (7 self)
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We investigated the hypothesis that people's facial activity influences their affective responses. Two studies were designed to both eliminate methodological problems of earlier experiments and clarify theoretical ambiguities, This was achieved by having subjects hold a pen in their mouth
Lateral interactions between spatial channels: Suppression and facilitation revealed by lateral masking experiments. Vision Res
, 1993
"... We measured contrast detection thresholds for a fovea1 Gabor signal flanked by two high contrast Gabor signals. The spatially localized target and masks enabled investigation of space depeudent lateral interactions between fovea1 and neighboring spatial chaonels. Our d+ta show a suppressive region e ..."
Abstract
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Cited by 231 (28 self)
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of two. Tbe interactions between the fovea1 target and the flanking Gabor signals are spatial-frequency am-l orientation speciiie in both regions, but less specific in the suppression region. Lateral masking Lateral inhibition Spatial filters Segmentation 1.
An Emergent Model Of Orientation Selectivity In Cat Visual Cortical Simple Cells
, 1995
"... It is well known that visual cortical neurons respond vigorously to a limited range of stimulus orientations, while their primary afferent inputs, neurons in the lateral geniculate nucleus (LGN) respond well to all orientations. Mechanisms based on intracortical inhibition and/or converging thalamoc ..."
Abstract
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Cited by 239 (10 self)
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that local intracortical excitation may provide the dominant source of orientation selective input. In agreement with experiment, model cortical cells exhibit sharp orientation selectivity despite receiving strong iso-- orientation inhibition, weak cross--orientation inhibition, no shunting inhibition
Reflexive and voluntary orienting of visual attention: Time course of activation and resistance to interruption
- JOURNAL OF EXPERIMENTAL PSYCHOLOGY: HUMAN PERCEPTION AND PERFORMANCE
, 1989
"... To study the mechanisms underlying covert orienting of attention in visual space, subjects were given advance cues indicating the probable locations of targets that they had to discriminate and localize. Direct peripheral cues (brightening of one of four boxes in peripheral vision) and symbolic cent ..."
Abstract
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Cited by 198 (0 self)
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and inhibition from peripheral and central cues were characteristic and different. Experiment 2 showed that voluntary orienting in response to symbolic central cues is interrupted by reflexive orienting to random peripheral flashes. Experiment 3 showed that irrelevant peripheral flashes also compete
Priming of pop-out: I. Role of features
- Memory & Cognition
, 1994
"... We examined a visual search task, in which observers responded to the high-acuityaspect of a pop-out target (shape of an odd-colored diamond or vernier offset of an odd spatial-frequency patch). Repetition of the attention-driving feature (color or spatial frequency) in this task primes the pop-out; ..."
Abstract
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Cited by 180 (4 self)
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is cumulative. Observers cannot willfully overcome the priming, which suggests that it is pas-sive and autonomous. Both target facilitation and distractor inhibition are evident; the former has a greater effect. The phenomenon shows complete binocular transfer. In a typical visual search experiment
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions
- J
, 1998
"... The human parvovirus adeno-associated virus (AAV) infects a broad range of cell types, including human, nonhuman primate, canine, murine, and avian. Although little is known about the initial events of virus infection, AAV is currently being developed as a vector for human gene therapy. Using define ..."
Abstract
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Cited by 174 (17 self)
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defined mutant CHO cell lines and standard biochemical assays, we demonstrate that heparan sulfate proteoglycans mediate both AAV attachment to and infection of target cells. Competition experiments using heparin, a soluble receptor analog, demonstrated dose-dependent inhibition of AAV attachment
Results 1 - 10
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9,167
