expression in various single, double, and triple maturation mutants, we have identified multiple regulatory links among all four genes. We found that one of the major roles of LEC2 was to upregulate FUS3 and ABI3. The lec2 mutation is responsible for a dramatic decrease in ABI3 and FUS3 expression, and most

The yeast pheromone response pathway is mediated by two G protein-linked receptors, each of which is expressed only in its specific cell type. The STE3DAF mutation results in inappropriate expression of the a-factor receptor inMATa cells. Expression of this receptor in the inappropriate cell type

/EBPa expression was altered. Consistent with in vivo data, FUS-DDIT3 MEFs and human liposarcoma cell lines showed a similar downregulation of both PPARc2 and C/EBPa expression. Complementation studies with PPARc but not C/EBPa rescued the differentiation block in committed adipocytic precursors expressing FUS

belonging to the Fus3/Kss1 class. Single nucleotide polymerphisms (SNPs) and insertion/deletion were detected in the coding region of PsMAPK1 among six Pst isolates. Real-time RT-PCR analyses revealed that PsMAPK1 expression was induced at early infection stages and peaked during haustorium formation. When

Focused ultrasound (FUS) was applied to muscle tissue in C3H/Km mice using a dual imaging/therapeutic system at continuous and pulsed wave mode. T2 and pre-and post-contrast T1 images were obtained on a 4.7 T scanner. Tissue changes after FUS treatment were clearly visible on MRI. Gene expression

on the histological integrity of muscle and does not induce cell death. Infiltration of macrophages was observed 3 and 8 days following pFUS or cFUS exposures. pFUS increased expression of several cytokines (e.g., IL-1a, IL-1b, TNFa, INFc, MIP-1a, MCP-1, and GMCSF) creating a local cytokine gradient on days 0 and 1

and phosphorylation in S. cerevisiae. In each of two experiments comparing yeast mutants bear-ing deletions in FUS3 or STE7 with their wild-type coun-terparts, we quantified over 4100 proteins, including all members of the yeast mating pathway. We also identified 12,499 unique phosphorylation sites in this work. We

. The GI pathogen enterohemorrhagic E.coli (EHEC) relies on inter-kingdom chemical sensing systems to regulate virulence gene expression3–4. Here we show that these systems control the expression of a novel two-component signal transduction system, named FusKR, where FusK is the histidine sensor kinase (HK

common regions (MCR) of gain or loss, of which five contained a single gene (MOCS2, NSUN3, KHDRBS2, SNTG1 and ST18). One larger MCR of gain contained NSD1. One focal amplification and nine gains contained FUS. NSD1 and FUS are oncogenes hitherto not known to be associated with lung cancer. FISH showed

Research article Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop Mattias K Andersson*, Melker Göransson, Anita Olofsson, Carola Andersson and Pierre Åman Background: The FUS-DDIT3 fusion oncogene encodes