, the framework is used to help explain how electronic markets and electronic hierarchies will allow closer integration of adjacent steps in the value added chains of our economy. The most surprising prediction is that information technology will lead to an overall shift toward proportionately more coordination

will play in knowledge management and in electronic commerce. In addition, I show how arising web standards such as RDF and XML can be used as

Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallo-graphic refinement and result in an incorrect struc-ture. The normally quoted crystallographic residual is often a poor description for the quality of the model. Strategies and tools are described that help to alleviate this problem. These simplify the model-building process, quantify the goodness of fit of the model on a per-residue basis and locate possible errors in pep-tide and side-chain conformations.

mystery. Electron microscopy has contributed to our understanding of ribosome structure ever since the ribosome was discovered. In the last few years, three-dimensional (3D) electron microscopic images of the ribosome have been produced at resolutions sufficiently high to visualize many of the proteins

, and each application can extend the core Tcl features with additional commands specific to that application.

of the language semantics. The approach easily extends from polymorphic functional languages to imperative languages that provide references, exceptions, continuations, and similar features. We illustrate the technique with a type soundness theorem for the core of Standard ML, which includes the first type

the history and philosophy of the Condor project and describe how it has interacted with other projects and evolved along with the field of distributed computing. We outline the core components of the Condor system and describe how the technology of computing must correspond to social structures. Throughout

application, the Apache web server. By using email archives of source code change history and problem reports we quantify aspects of developer participation, core team size, code ownership, productivity, defect density, and problem resolution interval for this OSS project. This analysis reveals a unique

. The core of Ptolemy is a set of object-oriented class definitions that makes few assumptions about the system to be modeled; rather, standard interfaces are provided for generic objects and more specialized, application-specific objects are derived from these. A basic abstraction in Ptolemy is the Domain

of the variance in user intentions to use information technology. Next, a unified model, called the Unified Theory of Acceptance and Use of Technology (UTAUT), was formulated, with four core determinants of intention and usage, and up to four moderators of key relationships. UTAUT was then tested using