THERE have been very few reports of uterine rupture in the cat in the literature (Webb 1972). The causes include external trauma during pregnancy, severe alterations of the wall of the uterus, inadequate obstetric manipulations, and the incorrect use of drugs such as oxytocin or prostaglandin F2ec

, Ferguson, & Kopstein, 1990). The consequences of drug abuse are acute on both a personal and a societal level. For the developing young adult, drug and alcohol abuse under-mines motivation, interferes with cognitive processes, contrib-

Schultz, Wolfram. Predictive reward signal of dopamine neurons. is called rewards, which elicit and reinforce approach behav-J. Neurophysiol. 80: 1–27, 1998. The effects of lesions, receptor ior. The functions of rewards were developed further during blocking, electrical self-stimulation, and drugs

be developed to sort out whether cancer tissues have distinctive signatures of gene expression over normal tissues or other types of cancer tissues. In this paper, we address the problem of selection of a small subset of genes from broad patterns of gene expression data, recorded on DNA micro-arrays. Using

, and stratiÞed squamous epithelium (ectoderm). These cell lines should be useful in human develop-mental biology, drug discovery, and transplantation medicine. Embryonic stem (ES) cells are derived from totipotent cells of the early mamma-lian embryo and are capable of unlimited, undifferentiated proliferation

Molecular targets for antiepileptic drug development

New macrophage models of Gaucher disease offer new tools

uq.edu.au Accepted for publication

Abstract not found

This paper replicates DiMasi et al (2003, 2004) estimates of expenditure on new drug development using publicly available data. The paper estimates that average expenditure on drugs in human clinical trials is around $25m per year, with $18m per year on drugs in Phase 1, $33m on drugs in Phase 2