The metabolic syndrome (MetS) represents a combination of cardiometabolic risk determinants including obesity (central adiposity), insulin resistance, glucose intolerance, dyslipidaemia, non-alcoholic fatty liver disease and hypertension. MetS is rapidly increasing in prevalence worldwide as a consequence of the continued obesity ‘‘epidemic’’, and as a result will have a considerable impact on the global incidence of cardiovascular disease and type 2 diabetes. Currently, there is debate concerning whether the risk of cardiovascular disease is greater in patients diagnosed with MetS than that of the sum of the individual risk factors. At present, no unifying origin that can explain the pathogenesis of MetS has been identified and therefore no unique pharmacological treatment is

Adolescent development and risk of injury: using

;once removed." The research question becomes: How are intrafamilial processes affected by extrafamilial conditions? Paradigm Parameters In tracing the evolution of research models in developmental science, Bronfenbrenner and Crouter (1983) distinguished a series of progressively more sophisticated

This Thesis is brought to you for free and open access by DigitalCommons@URI. It has been accepted for inclusion in Open Access Master's Theses by

Supervisors are listed by research department. Some research themes, for example, development, can be found across all the research departments and it is suggested that you look through the complete document. You can use the PDF bookmark view to bring up a navigation index that

Abstract: Clinical dementia associated with the appearance of Lewy bodies in the cerebral cortex has been recognized for over 40 years. Until the 1990s, however, cortical Lewy body disease was thought to be a rare cause of dementia. At that time, the advent of sensitive and specifi c immunohistochemical techniques for highlighting these elusive structures led to the recognition of cortical Lewy body disease as a common substrate for clinical dementia. Cur-rent diagnostic criteria recognize dementia with Lewy bodies as a clinicopathological entity. Also recognized is the closely related (and perhaps biologically identical) entity of Parkinson’s disease dementia, which differs from dementia with Lewy bodies only in the temporal sequence of appearance of clinical symptoms. The generic term “Lewy body disease ” encompasses both entities. There is frequent and extensive overlap, both clinically and pathologically, between dementia with Lewy bodies and Alzheimer’s disease. The two diseases share several genetic and environmental risk factors that have in common increased infl ammatory states associated with increased disease risk. Moreover, pathological and experimental work has implicated the involvement of activated microglia and of microglia-derived interleukin-1 in the pathogenesis of the pathognomonic lesions of both diseases. Such neuroinfl ammatory processes may be the common link driving progression in both diseases and explaining the frequent overlap between the two diseases.

. This approach is both a synthesis and extension of the works of developmental psychologists such as Mahler and Gessel, cognitive psychologists including Piaget and Kohlberg, humanistic psychologists such as Maslow and Rogers, transpersonal psychologists such as Wilber, anthropologists such as Bateson and Mead

The College of Education and Human Ecology has presented a proposal to create a new Graduate

The idea of successful development is used as the conceptual platform for a proposal that three basic principles of developmental science be expanded. Specifically, we propose that (a) developmental science needs to be reframed as a guide for what successful development is and how it is manifested

Multiple methods are vital to understanding development as a dynamic, transactional process. This article focuses on the ways in which quantitative and qualitative methodologies can be combined to enrich developmental science and the study of human development, focusing on the practical questions