functions, their large-scale structure is essentially unknown. Here we present the first systematic comparative mathematical analysis of the metabolic networks of 43 organisms representing all three domains of life. We show that, despite significant variances in their individual constituents and pathways

present in hypertext to produce better search results. This paper addresses this question of how to build a practical large-scale system which can exploit the additional information present in hypertext. Also we look at the problem of how to effectively deal with uncontrolled hypertext collections where

We propose a new scheme for content distribution of large files that is based on network coding. With network coding, each node of the distribution network is able to generate and transmit encoded blocks of information. The randomization introduced by the coding process eases the scheduling

Large-scale Internet applications can benefit from an ability to predict round-trip times to other hosts without having to contact them first. Explicit measurements are often unattractive because the cost of measurement can outweigh the benefits of exploiting proximity information. Vivaldi is a

The large-scale automated transaction systems of the near future can be designed to protect the privacy and maintain the security of both individuals and organizations. DAVID CHAUM Computerization is robbing individuals of the ability to monitor and control the ways information about them is used

novel sensor system, suitable for large-scale deployment in indoor environments, which allows the locations of people and equipment to be accurately determined. We also describe some of the context-aware applications that might make use of this fine-grained location information.

The large-scale behavior of routing in the Internet has gone virtually without any formal study, the exception being Chinoy's analysis of the dynamics of Internet routing information [Ch93]. We report on an analysis of 40,000 end-to-end route measurements conducted using repeated “traceroutes

The World Wide Web has succeeded in large part because its software architecture has been designed to meet the needs of an Internet-scale distributed hypermedia system. The Web has been iteratively developed over the past ten years through a series of modifications to the standards that define its

We describe a family of caching protocols for distrib-uted networks that can be used to decrease or eliminate the occurrence of hot spots in the network. Our protocols are particularly designed for use with very large networks such as the Internet, where delays caused by hot spots can be severe

sophisticated filtering mechanisms that take structure information into account. We have developed several index organizations and search algorithms for performing efficient filtering of XML documents for large-scale information dissemination systems. In this paper we describe these techniques and examine