Perched on a rocky ledge 400 m above flatter ground, fingers delicately searching for the right hold, one tends to appreciate the nature of balance. Elkhorn is Vancouver Island’s second highest peak at 2195 m, and our traverse was taking us across a bluffy section near the top. A miscalculation

Prof. Dr. med. Dr. h. c. Gerd Heusch

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with service assets may significantly reduce the drivers for the field of Service Science to continue in the future. This paper presents a cautionary tale of reusable service assets, where the balance between the knowledge and skills embodied in the asset and the utility of having expertise embodied in people

Inside eukaryotic cells there is a massive protein complex called the proteasome whose raison d’être is to remove unnecessary proteins by breaking them down into short peptides. The proteasome is thus responsible for an important aspect of cellular regulation because the timely and controlled proteolysis of key cellular factors regulates numerous biological processes such as cell cycle, differentiation, stress response, neuronal morphogenesis, cell surface receptor modulation, secretion, DNA repair, transcriptional regulation,

biology of aging are enabling growing numbers of adults to achieve extended life spans.1 Some of the most surprising research findings of recent years revolve around vitamin K.2,3 Scientists have discovered that vitamin K regulates several biochemical processes that require exquisite balance

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eXecuTiVe Summary Serious water problems-from issues of scarcity and security to poor quality-now affect a large proportion of the world's population. These challenges are particularly intense in regions with high population density, low average precipitation and weak economies. Given the current state of technology and necessarily limited water sources, administering and using water reasonably and efficiently is crucially important now and in the years ahead. This article considers the relationships among water supply stakeholders and several water management strategies including the "5E-principle" related to economic, environmental, equity, efficiency and energy factors. We advance a water management system and framework for meeting urban socio-economic growth challenges while maintaining water utilization sustainability, based on a notable Beijing experience.

Experimental allergic encephalomyelitis (EAE) is an animal model of multiple sclerosis that is induced by immunization with myelin antigens (1). The ability to generate EAE by activating myelin-specific T cells in the periphery of healthy animals demonstrates that central and peripheral mechanisms of tolerance are incomplete for these self-antigens. This lack of T cell tolerance toward myelin proteins was initially thought to be due to restricted expression of these antigens behind the blood–brain barrier. Recent data demonstrate that T cell epitopes from the two most abundant proteins in myelin, proteolipid protein (PLP) and myelin basic protein (MBP), are expressed not only within the central nervous system (CNS) and peripheral nervous system but within the thymus, spleen, and lymph nodes as well (2–6).