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Aging: a theory based on free radical and radiation chemistry

by Denham Harman, Ph. D - J Gerontol , 1956
"... The phenomenon of growth, decline and death-aging-has been the source of consider-able speculation (1, 8, 10). This cycle seems to be a more or less direct function of the meta-bolic rate and this in turn depends on the species (animal or plant) on which are super-imposed the factors of heredity and ..."
Abstract - Cited by 637 (2 self) - Add to MetaCart
and the effects of the stresses and strains of life-which alter the metabolic activity. The universality of this phenomenon sug-gests that the reactions which cause it are basic-ally the same in all living things. Viewing this process in the light of present day free radical and radiation chemistry

Base-calling of automated sequencer traces using phred. I. Accuracy Assessment

by Brent Ewing, Ladeana Hillier, Michael C. Wendl, Phil Green - GENOME RES , 1998
"... The availability of massive amounts of DNA sequence information has begun to revolutionize the practice of biology. As a result, current large-scale sequencing output, while impressive, is not adequate to keep pace with growing demand and, in particular, is far short of what will be required to obta ..."
Abstract - Cited by 1653 (4 self) - Add to MetaCart
accuracy. phred appears to be the first base-calling program to achieve a lower error rate than the ABI software, averaging 40%–50 % fewer errors in the data sets examined independent of position in read, machine running conditions, or sequencing chemistry.

Informed Prefetching and Caching

by R. Hugo Patterson, Garth A. Gibson, Eka Ginting, Daniel Stodolsky, Jim Zelenka - In Proceedings of the Fifteenth ACM Symposium on Operating Systems Principles , 1995
"... The underutilization of disk parallelism and file cache buffers by traditional file systems induces I/O stall time that degrades the performance of modern microprocessor-based systems. In this paper, we present aggressive mechanisms that tailor file system resource management to the needs of I/O-int ..."
Abstract - Cited by 402 (10 self) - Add to MetaCart
The underutilization of disk parallelism and file cache buffers by traditional file systems induces I/O stall time that degrades the performance of modern microprocessor-based systems. In this paper, we present aggressive mechanisms that tailor file system resource management to the needs of I

VPR: A New Packing, Placement and Routing Tool for FPGA Research

by Vaughn Betz, Jonathan Rose , 1997
"... We describe the capabilities of and algorithms used in a new FPGA CAD tool, Versatile Place and Route (VPR). In terms of minimizing routing area, VPR outperforms all published FPGA place and route tools to which we can compare. Although the algorithms used are based on previously known approaches ..."
Abstract - Cited by 322 (15 self) - Add to MetaCart
We describe the capabilities of and algorithms used in a new FPGA CAD tool, Versatile Place and Route (VPR). In terms of minimizing routing area, VPR outperforms all published FPGA place and route tools to which we can compare. Although the algorithms used are based on previously known

A molecular view of microbial diversity and the biosphere. Science 276:734–740

by Norman R. Pace , 1997
"... Over three decades of molecular-phylogenetic studies, researchers have compiled an increasingly robust map of evolutionary diversification showing that the main diversity of life is microbial, distributed among three primary relatedness groups or domains: Archaea, Bacteria, and Eucarya. The general ..."
Abstract - Cited by 341 (10 self) - Add to MetaCart
properties of representatives of the three domains indicate that the earliest life was based on inorganic nutrition and that photosynthesis and use of organic compounds for carbon and energy metabolism came comparatively later. The application of molecular-phylogenetic methods to study natural microbial

Fast Approximation Algorithms for Fractional Packing and Covering Problems

by Serge A. Plotkin, David B. Shmoys, Éva Tardos , 1995
"... This paper presents fast algorithms that find approximate solutions for a general class of problems, which we call fractional packing and covering problems. The only previously known algorithms for solving these problems are based on general linear programming techniques. The techniques developed ..."
Abstract - Cited by 260 (13 self) - Add to MetaCart
This paper presents fast algorithms that find approximate solutions for a general class of problems, which we call fractional packing and covering problems. The only previously known algorithms for solving these problems are based on general linear programming techniques. The techniques

Global simulation of tropospheric O3-NOx-hydrocarbon chemistry -- 1. Model formulation

by Yuhang Wang, Daniel J. Jacob, Jennifer A. Logan , 1998
"... We describe a global three-dimensional model for tropospheric O 3-NO x-hydrocarbon chemistry with synoptic-scale resolution. A suite of 15 chemical tracers, including O 3, NO x, PAN, HNO 3, CO, H 2 O 2, and various hydrocarbons, is simulated in the model. For computational expediency, chemical pro ..."
Abstract - Cited by 267 (89 self) - Add to MetaCart
We describe a global three-dimensional model for tropospheric O 3-NO x-hydrocarbon chemistry with synoptic-scale resolution. A suite of 15 chemical tracers, including O 3, NO x, PAN, HNO 3, CO, H 2 O 2, and various hydrocarbons, is simulated in the model. For computational expediency, chemical

Joint Scheduling and Power Control for Wireless Ad-hoc Networks

by Tamer ElBatt, Anthony Ephremides , 2002
"... In this pape we introduce powe r control as a solution tothe multiple accel proble in conte tion-base wiren-b ad-hocne works.The motivation for this study is two fold, limiting multi-use intej- toincre single hop throughput, andrej powe r consumption to increj batte life We focus onne ne bor transmi ..."
Abstract - Cited by 283 (6 self) - Add to MetaCart
In this pape we introduce powe r control as a solution tothe multiple accel proble in conte tion-base wiren-b ad-hocne works.The motivation for this study is two fold, limiting multi-use intej- toincre single hop throughput, andrej powe r consumption to increj batte life We focus onne ne bor

Residue-residue potentials with a favorable contact pair term and an unfavorable high packing density term, for simulation and threading

by Sanzo Miyazawa, Robert L. Jernigan , 1996
"... Attractive inter-residue contact energies for proteins have been re-evaluated with the same assumptions and approximations used originally by us in 1985, but with a significantly larger set of protein crystal structures. An additional repulsive packing energy term, operative at higher densities to p ..."
Abstract - Cited by 236 (12 self) - Add to MetaCart
Attractive inter-residue contact energies for proteins have been re-evaluated with the same assumptions and approximations used originally by us in 1985, but with a significantly larger set of protein crystal structures. An additional repulsive packing energy term, operative at higher densities

A Static Analyzer for Large Safety-Critical Software

by Bruno Blanchet, Patrick Cousot, Radhia Cousot, Jerome Feret, Laurent Mauborgne, Antoine Mine, David Monniaux, Xavier Rival , 2003
"... We show that abstract interpretation-based static program analysis can be made e#cient and precise enough to formally verify a class of properties for a family of large programs with few or no false alarms. This is achieved by refinement of a general purpose static analyzer and later adaptation to p ..."
Abstract - Cited by 271 (54 self) - Add to MetaCart
We show that abstract interpretation-based static program analysis can be made e#cient and precise enough to formally verify a class of properties for a family of large programs with few or no false alarms. This is achieved by refinement of a general purpose static analyzer and later adaptation
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