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An integrative theory of prefrontal cortex function.

by Earl K Miller , Jonathan D Cohen - Annual Review of Neuroscience, , 2001
"... Abstract The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active ..."
Abstract - Cited by 1093 (20 self) - Add to MetaCart
the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal

Identification of Prokaryotic and Eukaryotic Signal Peptides and Prediction of Their Cleavage Sites

by Henrik Nielsen, Jacob Engelbrecht, Søren Brunak, Gunnar von Heijne , 1997
"... We have developed a new method for identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequences. The method performs significantly better than previous prediction schemes, and can easily be applied on genome-wide ..."
Abstract - Cited by 787 (17 self) - Add to MetaCart
We have developed a new method for identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequences. The method performs significantly better than previous prediction schemes, and can easily be applied on genome

A New Approach to Manipulator Control: The Cerebellar Model Articulation Controller

by J. S. Albus - (CMAC), TRANS. ASME, SERIES G. JOURNAL OF DYNAMIC SYSTEMS, MEASUREMENT AND CONTROL , 1975
"... (CMAC) [1, 2] is a neural network that models the structure and function of the part of the brain known as the cerebellum. The cerebellum provides precise coordination of motor control for such body parts as the eyes, arms, fingers, legs, and wings. It stores and retrieves information required to co ..."
Abstract - Cited by 366 (5 self) - Add to MetaCart
(CMAC) [1, 2] is a neural network that models the structure and function of the part of the brain known as the cerebellum. The cerebellum provides precise coordination of motor control for such body parts as the eyes, arms, fingers, legs, and wings. It stores and retrieves information required

How brains beware: neural mechanisms of emotional attention

by Patrik Vuilleumier - Trends Cogn. Sci , 2005
"... Emotional processes not only serve to record the value of sensory events, but also to elicit adaptive responses and modify perception. Recent research using functional brain imaging in human subjects has begun to reveal neural substrates by which sensory processing and attention can be modulated by ..."
Abstract - Cited by 255 (15 self) - Add to MetaCart
Emotional processes not only serve to record the value of sensory events, but also to elicit adaptive responses and modify perception. Recent research using functional brain imaging in human subjects has begun to reveal neural substrates by which sensory processing and attention can be modulated

Bottom-Up Modeling of Cerebro-Cerebellar Interaction

by Lily Kim, Sungho Jo, Kazutaka Takahashi, Steve G. Massaquoi
"... The Problem: To obtain systems engineering models of the interaction between the brain’s principal motor exec-utive center, the cerebrum, and its principal ’coordinating ’ center, the cerebellum. Motivation: Increasing scientific data about the primate cerebellum appears to show that the organ provi ..."
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of the operation of cerebral and cerebellar neural pathways. To date, these models are able to describe both the input-output motor control behavior

Binocular Rivalry and Visual Awareness in Human Extrastriate Cortex

by Frank Tong, Ken Nakayama, J. Thomas Vaughan, Nancy Kanwisher , 1998
"... imaging (fMRI) to investigate whether activity in place area (PPA) during binocular rivalry in which a human extrastriate cortex is correlated to visual aware- face and a house stimulus were presented to different ness during binocular rivalry, and, more specifically, eyes. Though retinal stimulatio ..."
Abstract - Cited by 218 (16 self) - Add to MetaCart
activity; perceived changes from face to house led neural region, this would indicate that binocular rivalry to the opposite pattern of responses. These responses is resolved by this stage of the visual pathway. Such during rivalry were equal in magnitude to those evoked brai

A Neural Model Of Cerebellar Learning For Arm Movement Control: Cortico-Spino-Cerebellar Dynamics

by J.L. Contreras-Vidal, Stephen Grossberg, Daniel Bullock , 1997
"... A neural network model of opponent cerebellar learning for arm movement control is proposed. The model illustrates how a central pattern generator in cortex and basal ganglia, a neuromuscular force controller in spinal cord, and an adaptive cerebellum cooperate to reduce motor variability during mul ..."
Abstract - Cited by 36 (9 self) - Add to MetaCart
A neural network model of opponent cerebellar learning for arm movement control is proposed. The model illustrates how a central pattern generator in cortex and basal ganglia, a neuromuscular force controller in spinal cord, and an adaptive cerebellum cooperate to reduce motor variability during

The cerebellar cognitive affective syndrome

by Jeremy D. Schmahmann, Janet C. Sherman, Correspondence Jeremy, D. Schmahmann - Brain , 1998
"... Anatomical, physiological and functional neuroimaging studies suggest that the cerebellum participates in the organization of higher order function, but there are very few descriptions of clinically relevant cases that address this possibility. We performed neurological examinations, bedside mental ..."
Abstract - Cited by 85 (2 self) - Add to MetaCart
and visual–spatial functions. We have called this newly defined clinical entity the ‘cerebellar cognitive affective syndrome’. The constellation of deficits is suggestive of disruption of the cerebellar modulation of neural circuits that link prefrontal, posterior parietal, superior temporal and limbic

The neural circuit for touch sensitivity in Caenorhabditis elegans. J Neurosci 5:956–964

by Martin Chalfie, John E. Sulston, John G. White, Eileen Southgate, J. Nichol Thomson, Sydney Brenners , 1985
"... The neural pathways for touch-induced movement in Caenorhabditis ekgans contain six touch receptors, five pairs of interneurons, and 69 motor neurons. The synaptic relationships among these cells have been deduced from reconstructions from serial section electron micrographs, and the roles of the ce ..."
Abstract - Cited by 126 (1 self) - Add to MetaCart
The neural pathways for touch-induced movement in Caenorhabditis ekgans contain six touch receptors, five pairs of interneurons, and 69 motor neurons. The synaptic relationships among these cells have been deduced from reconstructions from serial section electron micrographs, and the roles

Activation of cortical and cerebellar motor areas during executed and imagined hand movements: An fMRI study

by Martin Lotze, Pedro Montoya, Michael Erb, Ernst Hülsmann, Herta Flor, Uwe Klose, Niels Birbaumer, Wolfgang Grodd - Journal of Cognitive Neuroscience , 1999
"... Brain activation during executed (EM) and imagined move-ments (IM) of the right and left hand was studied in 10 healthy right-handed subjects using functional magnetic resonance imagining (fMRI). Low electromyographic (EMG) activity of the musculi ºexor digitorum superªcialis and high vividness of ..."
Abstract - Cited by 108 (2 self) - Add to MetaCart
cerebellar activation was decreased during IM com-pared to EM. In the cerebellum, IM and EM differed in their foci of maximal activation: Highest ipsilateral activation of the cerebellum was observed in the anterior lobe (Larsell lobule H IV) during EM, whereas a lower maximum was found about 2-cm
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