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Characteristics of a human cell line transformed by DNA from human adenovirus type 5

by F. L. Graham, J. Smileyt, W. C. Russell, R. Nairn , 1977
"... Human embryonic kidney cells have been transformed by exposing cells to sheared fragments of adenovirus type 5 DNA. The transformed cells (designated 293 cells) exhibited many of the characteristics of transformation including the elaboration of a virus-specific tumour antigen. Analysis of the polyp ..."
Abstract - Cited by 676 (14 self) - Add to MetaCart
Human embryonic kidney cells have been transformed by exposing cells to sheared fragments of adenovirus type 5 DNA. The transformed cells (designated 293 cells) exhibited many of the characteristics of transformation including the elaboration of a virus-specific tumour antigen. Analysis

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.

by Ash A Alizadeh , Michael B Eisen , R Eric Davis , Chi Ma , Izidore S Lossos , Andreas Rosenwald , Jennifer C Boldrick , Hajeer Sabet , Truc Tran , Xin Yu , John I Powell , Liming Yang , Gerald E Marti , Troy Moore , James Hudson Jr , Lisheng Lu , David B Lewis , Robert Tibshirani , Gavin Sherlock , Wing C Chan , Timothy C Greiner , Dennis D Weisenburger , James O Armitage , Roger Warnke , Ronald Levy , Wyndham Wilson , Michael R Grever , John C Byrd , David Botstein , Patrick O Brown , Louis M Staudt - Nature , 2000
"... ..."
Abstract - Cited by 642 (10 self) - Add to MetaCart
Abstract not found

Metabolic stability and epigenesis in randomly connected nets

by S. A. Kauffman - Journal of Theoretical Biology , 1969
"... “The world is either the effect of cause or chance. If the latter, it is a world for all that, that is to say, it is a regular and beautiful structure.” Marcus Aurelius Proto-organisms probably were randomly aggregated nets of chemical reactions. The hypothesis that contemporary organisms are also r ..."
Abstract - Cited by 657 (5 self) - Add to MetaCart
: behave with great order and stability; undergo behavior cycles whose length predicts cell replication time as a function of the number of genes per cell; possess different modes of behavior whose number per net predicts roughly the number of cell types in an organism as a function of its number of genes

The serial cultivation of human diploid cell strains. Exp Cell Res

by L. Hayflick, P. S. Moorhead , 1961
"... ONLY limited success has been obtained in developing strains of human cells that can be cultivated for long periods of time in vitro and that still preserve the diploid chromosomal configuration [41, 47, 48, 58, 591. Indeed, heteroploidy may be a necessary corollary or even the cause of the altera-t ..."
Abstract - Cited by 497 (2 self) - Add to MetaCart
of the altera-tion of primary or diploid cells in vitro to the status of a cell line. Such changes in chromosome number appear to be independent of the type of primary tissue since they have been observed in cells derived from both normal and malignant tissue [4, 22, 23, 311. These cell lines, of which over two

Apoptosis: a Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

by J. F. R. Kerr, A. H. Wyllie, A. R. Curriet - Br. J. Cancer , 1972
"... Summary.-The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently program ..."
Abstract - Cited by 641 (6 self) - Add to MetaCart
types of therapeutically induced tumour regression. It is implicated in both physiological involution and atrophy of various tissues and organs. It can also be triggered by noxious agents, both in the embryo and adult animal. IN recent years it has become widely recognized that spontaneous loss of cells

Support Vector Machine Classification and Validation of Cancer Tissue Samples Using Microarray Expression Data

by Terrence S. Furey, Nello Cristianini, Nigel Duffy, David W. Bednarski, Michèl Schummer, David Haussler , 2000
"... Motivation: DNA microarray experiments generating thousands of gene expression measurements, are being used to gather information from tissue and cell samples regarding gene expression differences that will be useful in diagnosing disease. We have developed a new method to analyse this kind of data ..."
Abstract - Cited by 569 (1 self) - Add to MetaCart
of tissues is achieved, but not with high confidence. We identify and analyse a subset of genes from the ovarian dataset whose expression is highly differentiated between the types of tissues. To show robustness of the SVM method, two previously published datasets from other types of tissues or cells

Mapping and analysis of chromatin state dynamics in nine human cell types,”

by Jason Ernst , Pouya Kheradpour , Tarjei S Mikkelsen , Noam Shoresh , Lucas D Ward , Charles B Epstein , Xiaolan Zhang , Li Wang , Robbyn Issner , Michael Coyne , Manching Ku , Timothy Durham , Manolis Kellis , Bradley E Bernstein - Nature, , 2011
"... ..."
Abstract - Cited by 322 (18 self) - Add to MetaCart
Abstract not found

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

by Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda - Cell 2007
"... Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduct ..."
Abstract - Cited by 446 (3 self) - Add to MetaCart
, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity. Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts.

A simple distributed autonomous power control algorithm and its convergence

by Gerard J. Foschini, Zoran Miljanic - IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY , 1993
"... For wireless cellular communication systems, one seeks a simple effective means of power control of signals associated with randomly dispersed users that are reusing a single channel in different cells. By effecting the lowest interference environment, in meeting a required minimum signal-to-interf ..."
Abstract - Cited by 477 (3 self) - Add to MetaCart
For wireless cellular communication systems, one seeks a simple effective means of power control of signals associated with randomly dispersed users that are reusing a single channel in different cells. By effecting the lowest interference environment, in meeting a required minimum signal

Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis.

by Tzumin Lee , Liqun Luo - Neuron , 1999
"... We have modified an FLP/FRT-based genetic mosaic system to label either neurons derived from a common progenitor or isolated single neurons, in the Drosophila CNS. These uniquely labeled neurons can also be made homozygous for a mutation of interest within an otherwise phenotypically wild-type brai ..."
Abstract - Cited by 455 (22 self) - Add to MetaCart
We have modified an FLP/FRT-based genetic mosaic system to label either neurons derived from a common progenitor or isolated single neurons, in the Drosophila CNS. These uniquely labeled neurons can also be made homozygous for a mutation of interest within an otherwise phenotypically wild-type
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