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Results 11 - 20
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1,094
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"... Structure-activity relations for the inhibition of catecholamine uptake into synaptosomes from noradrenaline and dopaminergic neurones in rat brain homogenates ..."
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Structure-activity relations for the inhibition of catecholamine uptake into synaptosomes from noradrenaline and dopaminergic neurones in rat brain homogenates
Does the brain prefer geometrical homogeneity?
, 2010
"... Abstract. Some patients with frontotemporal lobar degeneration (FTLD) have shown the development of painting or musical abilities after the onset of the disease. In this report, we present another emergent ability. A female patient with FTLD showing dense atrophy of the bilateral anterior lobes and ..."
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of paper, she showed quite unique geometrical preferences. Her severely degenerated brain combined with her geometrical abilities suggests that the human brain is naturally affected by geometrical homogeneity.
Characterization of , and ␦ Opioid Binding in Amphibian Whole Brain Tissue Homogenates
"... ABSTRACT Opioid agonists produce analgesia in mammals through the activation of , , or ␦ opioid receptors. Previous behavioral and binding studies from our laboratory using an amphibian model suggested that , , or ␦ opioid agonists may activate a single type of opioid receptor in the grass frog, Ra ..."
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, Rana pipiens. In the present study, kinetic, saturation, and competitive binding profiles for three opioid radioligands, were determined using frog whole brain homogenates. Kinetic analyses and experimentally derived values from saturation experiments gave affinity constants (K D ) in the low nanomolar
Intensity Segmentation of the Human Brain with Tissue dependent Homogenization
, 2002
"... High-precision segmentation of the human cerebral cortex based on T1-weighted MRI is still a challenging task. When opting to use an intensity based approach, careful data processing is mandatory to overcome inaccuracies. They are caused by noise, partial volume effects and systematic signal intensi ..."
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brains is gained. The precision of this approach is shown using the Montreal brain phantom. Real data applications exemplify the advantage of the GM based approach, compared to the usual WM homogenization, allowing improved cortex segmentation.
Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
- Neuron
, 2006
"... Networks of GABAergic neurons are key elements in the generation of g oscillations in the brain. Computa-tional studies suggested that the emergence of co-herent oscillations requireshyperpolarizing inhibition. Here, we show that GABAA receptor-mediated inhibi-tion in mature interneurons of the hipp ..."
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Cited by 67 (2 self)
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-terspike interval for low levels of drive but prolongs it for high levels, leading to homogenization of neuro-nal firing rates. Thus, shunting inhibition may confer increased robustness to g oscillations in the brain.
Frequency Specificity of Regional Homogeneity in the
, 2014
"... Resting state-fMRI studies have found that the inter-areal correlations in cortical networks concentrate within ultra-low frequencies (0.01–0.04 Hz) while long-distance connections within subcortical networks distribute over a wider frequency range (0.01–0.14 Hz). However, the frequency characterist ..."
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characteristics of regional homogeneity (ReHo) in different areas are still unclear. To examine the ReHo properties in different frequency bands, a data-driven method, Empirical Mode Decomposition (EMD), was adopted to decompose the time series of each voxel into several components with distinct frequency bands
Homogeneity Measures for Multiphase Level Set
- Segmentation of Brain MRI,” in Proceedings of ISBI, 2006
"... This paper presents a new homogeneity measure for variational segmentation with multiple level set functions. We propose to modify the quadratic homogeneity measure to trade off the convexity of the function against a faster rate of convergence. We tested in two series of experiments the performance ..."
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Cited by 3 (1 self)
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the performance of this new homogeneity force at converging to appropriate partitioning of brain MRI data sets, over a large range of image spatial resolution and image quality, in terms of tissue homogeneity and contrast. 1.
Hyperefficient PrP Sc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique
- FEBS J
, 2009
"... Running title: Hyper-efficient mouse PrPSc amplification Abbreviations PrPSc, abnormal forms of prion protein; PrPC, normal cellular form of PrP; TSE, transmissible spongiform encephalopathy; BSE, bovine spongiform encephalopathy; CJD, Creutzfeldt-Jakob disease; mBSE, mouse-adapted BSE; PMCA, protei ..."
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Cited by 7 (0 self)
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, protein misfolding cyclic amplification; BH, brain homogenate; NBH, normal brain homogenate; PK, proteinase K; rMoPrP, recombinant mouse PrP. 2
Brain Tumor Boundary Detection in MR Image by Homogeneity Enhancement Process
"... Brain cancer can be counted among the most deadly and intractable diseases. Tumors may be embedded in regions of the brain that are critical to orchestrating the body’s vital functions, while they shed cells to invade other parts of the brain, forming more tumors too small to detect using convention ..."
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conventional imaging techniques. Brain cancer’s location and ability to spread quickly makes treatment with surgery or radiation like fighting an enemy hiding out among minefields and caves. Boundary detection in MRI with brain tumor is an important image processing technique applied in Radiology. The non-homogeneities
Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome
, 2014
"... The possibility that alterations in DNA methylation are mechanistic drivers of development, aging and susceptibility to disease is widely acknowledged, but evidence remains patchy or inconclusive. Of partic-ular interest in this regard is the brain, where it has been reported that DNA methylation im ..."
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, limbic system and brain stem. Inter-individual DMRs were readily detectable in these regions. These results lead to the surprising conclusion that, with the exception of cerebellum, DNA methylation patterns are more ho-mogeneous between different brain regions from the same individual, than
Results 11 - 20
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