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In Silico and In Vitro Studies on the Protein-Protein Interactions between Brugia malayi Immunomodulatory

by Protein Calreticulin, Human Cq, Sunita Yadav, Smita Gupta, Rabose Selvaraj, Pawan Kumar Doharey, Anita Verma
"... Filarial parasites modulate effective immune response of their host by releasing a variety of immunomodulatory molecules, which help in the long persistence of the parasite within the host. The present study was aimed to characterize an immunomodulatory protein of Brugia malayi and its interaction w ..."
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Filarial parasites modulate effective immune response of their host by releasing a variety of immunomodulatory molecules, which help in the long persistence of the parasite within the host. The present study was aimed to characterize an immunomodulatory protein of Brugia malayi and its interaction

In Vitro, In Silico and In Vivo Studies of Ursolic Acid as an Anti-Filarial Agent

by Komal Kalani, Vikas Kushwaha, Pooja Sharma, Richa Verma, Mukesh Srivastava, Feroz Khan
"... As part of our drug discovery program for anti-filarial agents from Indian medicinal plants, leaves of Eucalyptus tereticornis were chemically investigated, which resulted in the isolation and characterization of an anti-filarial agent, ursolic acid (UA) as a major constituent. Antifilarial activity ..."
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activity of UA against the human lymphatic filarial parasite Brugia malayi using in vitro and in vivo assays, and in silico docking search on glutathione-s-transferase (GST) parasitic enzyme were carried out. The UA was lethal to microfilariae (mf; LC100: 50; IC50: 8.84 mM) and female adult worms (LC100

Research Article Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1/Th2 Type Immune Response and Inhibits Larval Development in the Host

by Prashant K. Singh, Susheela Kushwaha, Ajay K. Rana, Shailja Misra-bhattacharya
"... License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lymphatic filariasis is a major debilitating disease, endemic in 72 countries putting more than 1.39 billion people at risk and 120 million are already infected. Despi ..."
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. Despite the significant progress in chemotherapeutic advancements, there is still need for other measures like development of an effective vaccine or discovery of novel drug targets. In this study, structural and immunological characterization of independent phosphoglycerate mutase of filarial parasite
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