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Alternative isoform regulation in human tissue transcriptomes

by Eric T. Wang, Rickard S, Shujun Luo, Irina Khrebtukova, Lu Zhang, Christine Mayr, Stephen F. Kingsmore, Gary P. Schroth, Christopher B. Burge - Nature , 2008
"... Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of ..."
Abstract - Cited by 525 (4 self) - Add to MetaCart
Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing

Efficient implementation of a BDD package

by Karl S. Brace, Richard L. Rudell, Randal E. Bryant - In Proceedings of the 27th ACM/IEEE conference on Design autamation , 1991
"... Efficient manipulation of Boolean functions is an important component of many computer-aided design tasks. This paper describes a package for manipulating Boolean functions based on the reduced, ordered, binary decision diagram (ROBDD) representation. The package is based on an efficient implementat ..."
Abstract - Cited by 500 (9 self) - Add to MetaCart
implementation of the if-then-else (ITE) operator. A hash table is used to maintain a strong carwnical form in the ROBDD, and memory use is improved by merging the hash table and the ROBDD into a hybrid data structure. A memory funcfion for the recursive ITE algorithm is implemented using a hash-based cache

Implementing data cubes efficiently

by Venky Harinarayan, Anand Rajaraman, Jeffrey D. Ulman - In SIGMOD , 1996
"... Decision support applications involve complex queries on very large databases. Since response times should be small, query optimization is critical. Users typically view the data as multidimensional data cubes. Each cell of the data cube is a view consisting of an aggregation of interest, like total ..."
Abstract - Cited by 545 (1 self) - Add to MetaCart
total sales. The values of many of these cells are dependent on the values of other cells in the data cube..A common and powerful query optimization technique is to materialize some or all of these cells rather than compute them from raw data each time. Commercial systems differ mainly in their approach

Network Time Protocol (Version 3) Specification, Implementation and Analysis

by David L. Mills , 1992
"... Note: This document consists of an approximate rendering in ASCII of the PostScript document of the same name. It is provided for convenience and for use in searches, etc. However, most tables, figures, equations and captions have not been rendered and the pagination and section headings are not ava ..."
Abstract - Cited by 522 (18 self) - Add to MetaCart
are not available. This document describes the Network Time Protocol (NTP), specifies its formal structure and summarizes information useful for its implementation. NTP provides the mechanisms to synchronize time and coordinate time distribution in a large, diverse internet operating at rates from mundane

The space complexity of approximating the frequency moments

by Noga Alon, Yossi Matias, Mario Szegedy - JOURNAL OF COMPUTER AND SYSTEM SCIENCES , 1996
"... The frequency moments of a sequence containing mi elements of type i, for 1 ≤ i ≤ n, are the numbers Fk = �n i=1 mki. We consider the space complexity of randomized algorithms that approximate the numbers Fk, when the elements of the sequence are given one by one and cannot be stored. Surprisingly, ..."
Abstract - Cited by 855 (12 self) - Add to MetaCart
The frequency moments of a sequence containing mi elements of type i, for 1 ≤ i ≤ n, are the numbers Fk = �n i=1 mki. We consider the space complexity of randomized algorithms that approximate the numbers Fk, when the elements of the sequence are given one by one and cannot be stored. Surprisingly

The Ensemble Kalman Filter: theoretical formulation And Practical Implementation

by Geir Evensen , 2003
"... The purpose of this paper is to provide a comprehensive presentation and interpretation of the Ensemble Kalman Filter (EnKF) and its numerical implementation. The EnKF has a large user group, and numerous publications have discussed applications and theoretical aspects of it. This paper reviews the ..."
Abstract - Cited by 482 (4 self) - Add to MetaCart
implementation. A program listing is given for some of the key subroutines. The paper also touches upon specific issues such as the use of nonlinear measurements, in situ profiles of temperature and salinity, and data which are available with high frequency in time. An ensemble based optimal interpolation (En

On the statistical analysis of dirty pictures

by Julian Besag - JOURNAL OF THE ROYAL STATISTICAL SOCIETY B , 1986
"... ..."
Abstract - Cited by 1242 (5 self) - Add to MetaCart
Abstract not found

Multipoint quantitative-trait linkage analysis in general pedigrees

by Laura Almasy, John Blangero - Am. J. Hum. Genet , 1998
"... Multipoint linkage analysis of quantitative-trait loci (QTLs) has previously been restricted to sibships and small pedigrees. In this article, we show how variance-component linkage methods can be used in pedigrees of arbitrary size and complexity, and we develop a general framework for multipoint i ..."
Abstract - Cited by 549 (56 self) - Add to MetaCart
and the increase in power pro-vided by multipoint analysis with 5-, 10-, and 20-cM marker maps. The general pedigree variance component and IBD estimation methods have been implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package.

EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis

by Arnaud Delorme, Scott Makeig - J. Neurosci. Methods
"... Abstract: We have developed a toolbox and graphic user interface, EEGLAB, running under the cross-platform MATLAB environment (The Mathworks, Inc.) for processing collections of single-trial and/or averaged EEG data of any number of channels. Available functions include EEG data, channel and event i ..."
Abstract - Cited by 836 (44 self) - Add to MetaCart
information importing, data visualization (scrolling, scalp map and dipole model plotting, plus multi-trial ERP-image plots), preprocessing (including artifact rejection, filtering, epoch selection, and averaging), Independent Component Analysis (ICA) and time/frequency decompositions including channel

Economic analysis of cross section and panel data

by Jeffrey M. Wooldridge
"... ..."
Abstract - Cited by 3292 (18 self) - Add to MetaCart
Abstract not found
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