In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between

Ptolemy is an environment for simulation and prototyping of heterogeneous systems. It uses modern object-oriented software technology (C++) to model each subsystem in a natural and efficient manner, and to integrate these subsystems into a whole. Ptolemy encompasses practically all aspects

This paper describes the language Lustre, which is a dataflow synchronous language, designed for programming reactive systems --- such as automatic control and monitoring systems --- as well as for describing hardware. The dataflow aspect of Lustre makes it very close to usual description tools

). The aim is to explicate a set of general concepts, of relevance across a wide range of situations and, therefore, helping communication and cooperation among a number of scientific and technical communities, including ones that are concentrating on particular types of system, of system failures

Software architectures shift the focus of developers from lines-of-code to coarser-grained architectural elements and their overall interconnection structure. Architecture description languages (ADLs) have been proposed as modeling notations to support architecture-based development. There is, however, little consensus in the research community on what is an ADL, what aspects of an architecture should be modeled in an ADL, and which of several possible ADLs is best suited for a particular problem. Furthermore, the distinction is rarely made between ADLs on one hand and formal specification, module interconnection, simulation, and programming languages on the other. This paper attempts to provide an answer to these questions. It motivates and presents a definition and a classification framework for ADLs. The utility of the definition is demonstrated by using it to differentiate ADLs from other modeling notations. The framework is used to classify and compare several existing ADLs, enabling us in the process to identify key properties of ADLs. The comparison highlights areas where existing ADLs provide extensive support and those in which they are deficient, suggesting a research agenda for the future.

El Salvador, Guatemala is a, study in black and white. On the left is a collection of extreme Marxist-Leninist groups led by what one diplomat calls “a pretty faceless bunch of people.’ ’ On the right is an entrenched elite that has dominated Central America’s most populous country since a CIA-backed coup deposed the reformist government of Col. Jacobo Arbenz Guzmán in 1954. Moderates of the political center. embattled but alive in E1 Salvador, have virtually disappeared in Guatemala-joining more than 30.000 victims of terror over the last tifteen vears. “The situation in Guatemala is much more serious than in EI Salvador, ” declares one Latin American diplomat. “The oligarchy is that much more reactionary. and the choices are far fewer. “ ‘Zero’: The Guatemalan oligarchs hated Jimmy Carter for cutting off U.S. military aid in 1977 to protest human-rights abuses-and the right-wingers hired marimba bands and set off firecrackers on the night Ronald Reagan was elected. They considered Reagan an ideological kinsman and believed they had a special

of the altera-tion of primary or diploid cells in vitro to the status of a cell line. Such changes in chromosome number appear to be independent of the type of primary tissue since they have been observed in cells derived from both normal and malignant tissue [4, 22, 23, 311. These cell lines, of which over two

executed. We present a new algorithm to extract a process modelf3q such a log and represent it in terms of a Petri net. However, we will also demonstrate that it is not possible to discover arbitrary workflow processes. In this paper we explore a classof workflow processes that can be discovered. We show

The first edition of this book was published in 1992 by Wiley (ISBN 0 471 93609 X). Since this book is now out of print, and to answer the request of several colleagues, the authors have decided to make it available freely on the Web, while retaining the copyright, for the benefit of the scientific community. Copyright Statement This electronic document is in PDF format. One needs Acrobat Reader (available freely for most platforms from the Adobe web site) to benefit from the full interactive machinery: using the package hyperref by Sebastian Rahtz, the table of contents and all LATEX cross-references are automatically converted into clickable hyperlinks, bookmarks are generated automatically, etc.. So, do not hesitate to click on references to equation or section numbers, on items of thetableofcontents and of the index, etc.. One may freely use and print this document for one’s own purpose or even distribute it freely, but not commercially, provided it is distributed in its entirety and without modifications, including this preface and copyright statement. Any use of thecontents should be acknowledged according to the standard scientific practice. The

We apply the symbolic analysis principle to pushdown systems. We represent (possibly infinite) sets of configurations of such systems by means of finite-state automata. In order to reason in a uniform way about analysis problems involving both existential and universal path quantification (like