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ModelBased Clustering, Discriminant Analysis, and Density Estimation
 JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
, 2000
"... Cluster analysis is the automated search for groups of related observations in a data set. Most clustering done in practice is based largely on heuristic but intuitively reasonable procedures and most clustering methods available in commercial software are also of this type. However, there is little ..."
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Cited by 557 (28 self)
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for modelbased clustering that provides a principled statistical approach to these issues. We also show that this can be useful for other problems in multivariate analysis, such as discriminant analysis and multivariate density estimation. We give examples from medical diagnosis, mineeld detection, cluster
Contour Tracking By Stochastic Propagation of Conditional Density
, 1996
"... . In Proc. European Conf. Computer Vision, 1996, pp. 343356, Cambridge, UK The problem of tracking curves in dense visual clutter is a challenging one. Trackers based on Kalman filters are of limited use; because they are based on Gaussian densities which are unimodal, they cannot represent s ..."
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Cited by 658 (24 self)
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. In Proc. European Conf. Computer Vision, 1996, pp. 343356, Cambridge, UK The problem of tracking curves in dense visual clutter is a challenging one. Trackers based on Kalman filters are of limited use; because they are based on Gaussian densities which are unimodal, they cannot represent
CONDENSATION  conditional density propagation for visual tracking
 International Journal of Computer Vision
, 1998
"... The problem of tracking curves in dense visual clutter is challenging. Kalman filtering is inadequate because it is based on Gaussian densities which, being unimodal, cannot represent simultaneous alternative hypotheses. The Condensation algorithm uses "factored sampling", previously appli ..."
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Cited by 1499 (12 self)
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tracking of agile motion. Notwithstanding the use of stochastic methods, the algorithm runs in near realtime. Contents 1 Tracking curves in clutter 2 2 Discretetime propagation of state density 3 3 Factored sampling 6 4 The Condensation algorithm 8 5 Stochastic dynamical models for curve motion 10 6
LOF: Identifying DensityBased Local Outliers
 PROCEEDINGS OF THE 2000 ACM SIGMOD INTERNATIONAL CONFERENCE ON MANAGEMENT OF DATA
, 2000
"... For many KDD applications, such as detecting criminal activities in Ecommerce, finding the rare instances or the outliers, can be more interesting than finding the common patterns. Existing work in outlier detection regards being an outlier as a binary property. In this paper, we contend that for m ..."
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Cited by 499 (14 self)
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For many KDD applications, such as detecting criminal activities in Ecommerce, finding the rare instances or the outliers, can be more interesting than finding the common patterns. Existing work in outlier detection regards being an outlier as a binary property. In this paper, we contend that for many scenarios, it is more meaningful to assign to each object a degree of being an outlier. This degree is called the local outlier factor (LOF) of an object. It is local in that the degree depends on how isolated the object is with respect to the surrounding neighborhood. We give a detailed formal analysis showing that LOF enjoys many desirable properties. Using realworld datasets, we demonstrate that LOF can be used to find outliers which appear to be meaningful, but can otherwise not be identified with existing approaches. Finally, a careful performance evaluation of our algorithm confirms we show that our approach of finding local outliers can be practical.
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. sect
 A
, 1991
"... Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallographic refinement and result in an incorrect structure. The normally quoted crystallographic residual is often a poor description for the q ..."
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Cited by 1016 (9 self)
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Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallographic refinement and result in an incorrect structure. The normally quoted crystallographic residual is often a poor description for the quality of the model. Strategies and tools are described that help to alleviate this problem. These simplify the modelbuilding process, quantify the goodness of fit of the model on a perresidue basis and locate possible errors in peptide and sidechain conformations.
Probabilistic Visual Learning for Object Representation
, 1996
"... We present an unsupervised technique for visual learning which is based on density estimation in highdimensional spaces using an eigenspace decomposition. Two types of density estimates are derived for modeling the training data: a multivariate Gaussian (for unimodal distributions) and a Mixtureof ..."
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Cited by 705 (15 self)
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We present an unsupervised technique for visual learning which is based on density estimation in highdimensional spaces using an eigenspace decomposition. Two types of density estimates are derived for modeling the training data: a multivariate Gaussian (for unimodal distributions) and a Mixture
The irreducibility of the space of curves of given genus
 Publ. Math. IHES
, 1969
"... Fix an algebraically closed field k. Let Mg be the moduli space of curves of genus g over k. The main result of this note is that Mg is irreducible for every k. Of course, whether or not M s is irreducible depends only on the characteristic of k. When the characteristic s o, we can assume that k ~ ..."
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Cited by 512 (2 self)
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~ (1, and then the result is classical. A simple proof appears in EnriquesChisini [E, vol. 3, chap. 3], based on analyzing the totality of coverings of p1 of degree n, with a fixed number d of ordinary branch points. This method has been extended to char. p by William Fulton [F], using specializations
KodairaSpencer theory of gravity and exact results for quantum string amplitudes
 Commun. Math. Phys
, 1994
"... We develop techniques to compute higher loop string amplitudes for twisted N = 2 theories with ĉ = 3 (i.e. the critical case). An important ingredient is the discovery of an anomaly at every genus in decoupling of BRST trivial states, captured to all orders by a master anomaly equation. In a particu ..."
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Cited by 545 (60 self)
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’ of holomorphic curves of higher genus curves in Calabi–Yau manifolds. It is shown that topological amplitudes can also be reinterpreted as computing corrections to superpotential terms appearing in the effective 4d theory resulting from compactification of standard 10d superstrings on the corresponding N = 2
Alternative isoform regulation in human tissue transcriptomes
 Nature
, 2008
"... Through alternative processing of premRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an indepth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of ..."
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Cited by 525 (4 self)
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specific read densities indicated that a majority of AS and of alternative cleavage and polyadenylation (APA) events vary between tissues, while variation between individuals was ∼2 to 3fold less common. Extreme or ‘switchlike ’ regulation of splicing between tissues was associated with increased sequence
Numerical integration of the Cartesian equations of motion of a system with constraints: molecular dynamics of nalkanes
 J. Comput. Phys
, 1977
"... A numerical algorithm integrating the 3N Cartesian equations of motion of a system of N points subject to holonomic constraints is formulated. The relations of constraint remain perfectly fulfilled at each step of the trajectory despite the approximate character of numerical integration. The method ..."
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Cited by 682 (6 self)
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(MD), which has been widely used in the past for studying simple liquids and solids, has more recently been applied to molecular systems with internal degrees of freedom such as N, [l], H,O [2] and even C,H,, [3]. In applying the MD method three problems arise: (a) the choice of a suitable mechanical
Results 1  10
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3,876,584