The present review highlights an association between autism, Alzheimer disease (AD), and fragile X syndrome (FXS). We propose a conceptual framework involving the amyloid- peptide (A), A precursor protein (APP), and fragile X mental retardation protein (FMRP) based on experimental evidence

aspecten van kinderlijk autisme)

photographs via apps developed in close partnership with geriatric facilities. This study addresses cognitive functioning and quality of life for people diagnosed with dementia via technology. Research has shown that technology instruments such as iPods, help stimulate those with dementia. This study focuses

Abstract The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and autism. The disease is caused by mutations or loss of the Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein playing multiple functions in RNA metabolism. The expression of a large set

1400-1430 Dementia in the developing world

was previously shown to decrease secreted Ab, although the mechanism of this is unclear. In SH-SY5Y cells overexpressing APP and transiently transfected with LRRTM3 alone or with BACE1, we showed that LRRTM3 co-localizes with both APP and BACE1 in early endosomes, where BACE1 processing of APP occurs

The Centre for Health Program Evaluation (CHPE) is a research and teaching organisation established in 1990 to: · undertake academic and applied research into health programs, health systems and current policy issues; · develop appropriate evaluation methodologies; and · promote the teaching of health economics and health program evaluation, in order to increase the supply of trained specialists and to improve the level of understanding in the health community. The Centre comprises two independent research units, the Health Economics Unit (HEU)

putative binding partners of amyloid precursor protein (APP)

Psychosis and autism as diametrical disorders of the social brain

to the pain experiences of people with a learning difficulty and dementia