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The Restriction Scaffold Problem
 Journal of Computational Biology
, 2003
"... Most shotgun sequencing projects undergo a long and costly phase of finishing, in which a partial assembly forms several contigs whose order, orientation and relative distance is unknown. We propose here a new technique that supplements the shotgun assembly data by experimentally simple and commonly ..."
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Cited by 17 (0 self)
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and commonly used complete restriction digests of the target. By computationally combining information from the contig sequences and the fragment sizes measured for several different enzymes, we seek to form a "scaffold" on which the contigs will be placed in their correct orientation, order
A Note on the Confinement Problem
, 1973
"... This not explores the problem of confining a program during its execution so that it cannot transmit information to any other program except its caller. A set of examples attempts to stake out the boundaries of the problem. Necessary conditions for a solution are stated and informally justified. ..."
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Cited by 532 (0 self)
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This not explores the problem of confining a program during its execution so that it cannot transmit information to any other program except its caller. A set of examples attempts to stake out the boundaries of the problem. Necessary conditions for a solution are stated and informally justified.
Where the REALLY Hard Problems Are
 IN J. MYLOPOULOS AND R. REITER (EDS.), PROCEEDINGS OF 12TH INTERNATIONAL JOINT CONFERENCE ON AI (IJCAI91),VOLUME 1
, 1991
"... It is well known that for many NPcomplete problems, such as KSat, etc., typical cases are easy to solve; so that computationally hard cases must be rare (assuming P != NP). This paper shows that NPcomplete problems can be summarized by at least one "order parameter", and that the hard p ..."
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Cited by 681 (1 self)
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It is well known that for many NPcomplete problems, such as KSat, etc., typical cases are easy to solve; so that computationally hard cases must be rare (assuming P != NP). This paper shows that NPcomplete problems can be summarized by at least one "order parameter", and that the hard
The Vocabulary Problem in HumanSystem Communication
 COMMUNICATIONS OF THE ACM
, 1987
"... In almost all computer applications, users must enter correct words for the desired objects or actions. For success without extensive training, or in firsttries for new targets, the system must recognize terms that will be chosen spontaneously. We studied spontaneous word choice for objects in five ..."
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Cited by 551 (8 self)
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In almost all computer applications, users must enter correct words for the desired objects or actions. For success without extensive training, or in firsttries for new targets, the system must recognize terms that will be chosen spontaneously. We studied spontaneous word choice for objects in five applicationrelated domains, and found the variability to be surprisingly large. In every case two people favored the same term with probability <0.20. Simulations show how this fundamental property of language limits the success of various design methodologies for vocabularydriven interaction. For example, the popular approach in which access is via one designer's favorite single word will result in 8090 percent failure rates in many common situations. An optimal strategy, unlimited aliasing, is derived and shown to be capable of severalfold improvements.
Unified analysis of discontinuous Galerkin methods for elliptic problems
 SIAM J. Numer. Anal
, 2001
"... Abstract. We provide a framework for the analysis of a large class of discontinuous methods for secondorder elliptic problems. It allows for the understanding and comparison of most of the discontinuous Galerkin methods that have been proposed over the past three decades for the numerical treatment ..."
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Cited by 519 (31 self)
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Abstract. We provide a framework for the analysis of a large class of discontinuous methods for secondorder elliptic problems. It allows for the understanding and comparison of most of the discontinuous Galerkin methods that have been proposed over the past three decades for the numerical
Cognitive load during problem solving: effects on learning
 COGNITIVE SCIENCE
, 1988
"... Considerable evidence indicates that domain specific knowledge in the form of schemes is the primary factor distinguishing experts from novices in problemsolving skill. Evidence that conventional problemsolving activity is not effective in schema acquisition is also accumulating. It is suggested t ..."
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Cited by 603 (13 self)
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Considerable evidence indicates that domain specific knowledge in the form of schemes is the primary factor distinguishing experts from novices in problemsolving skill. Evidence that conventional problemsolving activity is not effective in schema acquisition is also accumulating. It is suggested
A New Method for Solving Hard Satisfiability Problems
 AAAI
, 1992
"... We introduce a greedy local search procedure called GSAT for solving propositional satisfiability problems. Our experiments show that this procedure can be used to solve hard, randomly generated problems that are an order of magnitude larger than those that can be handled by more traditional approac ..."
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Cited by 734 (21 self)
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We introduce a greedy local search procedure called GSAT for solving propositional satisfiability problems. Our experiments show that this procedure can be used to solve hard, randomly generated problems that are an order of magnitude larger than those that can be handled by more traditional
Theoretical improvements in algorithmic efficiency for network flow problems

, 1972
"... This paper presents new algorithms for the maximum flow problem, the Hitchcock transportation problem, and the general minimumcost flow problem. Upper bounds on ... the numbers of steps in these algorithms are derived, and are shown to compale favorably with upper bounds on the numbers of steps req ..."
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Cited by 565 (0 self)
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This paper presents new algorithms for the maximum flow problem, the Hitchcock transportation problem, and the general minimumcost flow problem. Upper bounds on ... the numbers of steps in these algorithms are derived, and are shown to compale favorably with upper bounds on the numbers of steps
Results 1  10
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2,126,578