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231,127
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
 Science
, 2000
"... ation, and termination phases of protein synthesis. Because the structures of several DNA and RNA polymerases have been determined at atomic resolution, the mechanisms of DNA and RNA synthesis are both well understood. Determination of the structure of the ribosome, however, has proven a daunting t ..."
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Cited by 529 (13 self)
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ation, and termination phases of protein synthesis. Because the structures of several DNA and RNA polymerases have been determined at atomic resolution, the mechanisms of DNA and RNA synthesis are both well understood. Determination of the structure of the ribosome, however, has proven a daunting
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. sect
 A
, 1991
"... Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallographic refinement and result in an incorrect structure. The normally quoted crystallographic residual is often a poor description for the q ..."
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Cited by 1016 (9 self)
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Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallographic refinement and result in an incorrect structure. The normally quoted crystallographic residual is often a poor description for the quality of the model. Strategies and tools are described that help to alleviate this problem. These simplify the modelbuilding process, quantify the goodness of fit of the model on a perresidue basis and locate possible errors in peptide and sidechain conformations.
SelfSimilarity Through HighVariability: Statistical Analysis of Ethernet LAN Traffic at the Source Level
 IEEE/ACM TRANSACTIONS ON NETWORKING
, 1997
"... A number of recent empirical studies of traffic measurements from a variety of working packet networks have convincingly demonstrated that actual network traffic is selfsimilar or longrange dependent in nature (i.e., bursty over a wide range of time scales)  in sharp contrast to commonly made tr ..."
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Cited by 740 (24 self)
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analyses of realtime traffic measurements from Ethernet LAN's at the level of individual sources. This paper is an extended version of [53] and differs from it in significant ways. In particular, we develop here the mathematical results concerning the superposition of strictly alternating ON
Compressive sampling
, 2006
"... Conventional wisdom and common practice in acquisition and reconstruction of images from frequency data follow the basic principle of the Nyquist density sampling theory. This principle states that to reconstruct an image, the number of Fourier samples we need to acquire must match the desired res ..."
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Cited by 1427 (15 self)
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Conventional wisdom and common practice in acquisition and reconstruction of images from frequency data follow the basic principle of the Nyquist density sampling theory. This principle states that to reconstruct an image, the number of Fourier samples we need to acquire must match the desired
Numerical integration of the Cartesian equations of motion of a system with constraints: molecular dynamics of nalkanes
 J. Comput. Phys
, 1977
"... A numerical algorithm integrating the 3N Cartesian equations of motion of a system of N points subject to holonomic constraints is formulated. The relations of constraint remain perfectly fulfilled at each step of the trajectory despite the approximate character of numerical integration. The method ..."
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Cited by 682 (6 self)
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is applied to a molecular dynamics simulation of a liquid of 64 nbutane molecules and compared to a simulation using generalized coordinates. The method should be useful for molecular dynamics calculations on large molecules with internal degrees of freedom. 1. INTR~D~JCTI~N The method of molecular dynamics
The SWISSMODEL Workspace: A webbased environment for protein structure homology modelling
 BIOINFORMATICS
, 2005
"... Motivation: Homology models of proteins are of great interest for planning and analyzing biological experiments when no experimental threedimensional structures are available. Building homology models requires specialized programs and uptodate sequence and structural databases. Integrating all re ..."
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Cited by 555 (5 self)
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Motivation: Homology models of proteins are of great interest for planning and analyzing biological experiments when no experimental threedimensional structures are available. Building homology models requires specialized programs and uptodate sequence and structural databases. Integrating all required tools, programs and databases into a single webbased workspace facilitates access to homology modelling from a computer with web connection without the need of downloading and installing large program packages and databases. Results: SWISSMODEL Workspace is a webbased integrated service dedicated to protein structure homology modelling. It assists and guides the user in building protein homology models at different levels of complexity. A personal working environment is provided for each user where several modelling projects can be carried out in parallel. Protein sequence and structure databases necessary for modelling are accessible from the workspace and are updated in regular intervals. Tools for template selection, model building, and structure quality evaluation can be invoked from within the workspace. Workflow and usage of the workspace are illustrated by modelling human Cyclin A1 and human Transmembrane Protease
Simulating Physics with Computers
 SIAM Journal on Computing
, 1982
"... A digital computer is generally believed to be an efficient universal computing device; that is, it is believed able to simulate any physical computing device with an increase in computation time of at most a polynomial factor. This may not be true when quantum mechanics is taken into consideration. ..."
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Cited by 601 (1 self)
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A digital computer is generally believed to be an efficient universal computing device; that is, it is believed able to simulate any physical computing device with an increase in computation time of at most a polynomial factor. This may not be true when quantum mechanics is taken into consideration. This paper considers factoring integers and finding discrete logarithms, two problems which are generally thought to be hard on a classical computer and have been used as the basis of several proposed cryptosystems. Efficient randomized algorithms are given for these two problems on a hypothetical quantum computer. These algorithms take a number of steps polynomial in the input size, e.g., the number of digits of the integer to be factored. AMS subject classifications: 82P10, 11Y05, 68Q10. 1 Introduction One of the first results in the mathematics of computation, which underlies the subsequent development of much of theoretical computer science, was the distinction between computable and ...
Wireless Communications
, 2005
"... Copyright c ○ 2005 by Cambridge University Press. This material is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University ..."
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Cited by 1129 (32 self)
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Copyright c ○ 2005 by Cambridge University Press. This material is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University
Quantum Gravity
, 2004
"... We describe the basic assumptions and key results of loop quantum gravity, which is a background independent approach to quantum gravity. The emphasis is on the basic physical principles and how one deduces predictions from them, at a level suitable for physicists in other areas such as string theor ..."
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Cited by 566 (11 self)
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We describe the basic assumptions and key results of loop quantum gravity, which is a background independent approach to quantum gravity. The emphasis is on the basic physical principles and how one deduces predictions from them, at a level suitable for physicists in other areas such as string theory, cosmology, particle physics, astrophysics and condensed matter physics. No details are given, but references are provided to guide the interested reader to the literature. The present state of knowledge is summarized in a list of 35 key results on topics including the hamiltonian and path integral quantizations, coupling to matter, extensions to supergravity and higher dimensional theories, as well as applications to black holes, cosmology and Plank scale phenomenology. We describe the near term prospects for observational tests of quantum theories of gravity and the expectations that loop quantum gravity may provide predictions for their outcomes. Finally, we provide answers to frequently asked questions and a list of key open problems.
Powerlaw distributions in empirical data
 ISSN 00361445. doi: 10.1137/ 070710111. URL http://dx.doi.org/10.1137/070710111
, 2009
"... Powerlaw distributions occur in many situations of scientific interest and have significant consequences for our understanding of natural and manmade phenomena. Unfortunately, the empirical detection and characterization of power laws is made difficult by the large fluctuations that occur in the t ..."
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Cited by 589 (7 self)
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Powerlaw distributions occur in many situations of scientific interest and have significant consequences for our understanding of natural and manmade phenomena. Unfortunately, the empirical detection and characterization of power laws is made difficult by the large fluctuations that occur in the tail of the distribution. In particular, standard methods such as leastsquares fitting are known to produce systematically biased estimates of parameters for powerlaw distributions and should not be used in most circumstances. Here we describe statistical techniques for making accurate parameter estimates for powerlaw data, based on maximum likelihood methods and the KolmogorovSmirnov statistic. We also show how to tell whether the data follow a powerlaw distribution at all, defining quantitative measures that indicate when the power law is a reasonable fit to the data and when it is not. We demonstrate these methods by applying them to twentyfour realworld data sets from a range of different disciplines. Each of the data sets has been conjectured previously to follow a powerlaw distribution. In some cases we find these conjectures to be consistent with the data while in others the power law is ruled out.
Results 1  10
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