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JOURNAL OF MAGNETIC RESONANCE IMAGING 31:1311–1322 (2010) Original Research Automatic Segmentation of White Matter Hyperintensities in the Elderly Using FLAIR Images at 3T

by Nancy J. Lobaugh , 2009
"... Purpose: To determine the precision and accuracy of an automated method for segmenting white matter hyperintensities (WMH) on fast fluid-attenuated inversion-recovery (FLAIR) images in elderly brains at 3T. Materials and Methods: FLAIR images from 18 individuals (60–82 years, 9 females) with WMH bur ..."
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burdens ranging from 1–80 cm 3 were used. The protocol included the removal of clearly hyperintense voxels; two-class fuzzy C-means clustering (FCM); and thresholding to segment probable WMH. Two false-positive minimization (FPM) methods using white matter templates were tested. Precision was assessed

Research Article Automated White Matter Hyperintensity Detection in Multiple Sclerosis Using 3D T2 FLAIR

by Yi Zhong, David Utriainen, Ying Wang, Yan Kang, E. Mark Haacke
"... Copyright © 2014 Yi Zhong et al.This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. White matter hyperintensities (WMH) seen on T2WI are a ..."
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Copyright © 2014 Yi Zhong et al.This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. White matter hyperintensities (WMH) seen on T2WI

White matter lesions impair frontal lobe function regardless of their location

by unknown authors
"... Abstract—Objective: To analyze the effect of white matter lesions in different brain regions on regional cortical glucose metabolism, regional cortical atrophy, and cognitive function in a sample with a broad range of cerebrovascular disease and cognitive function. Methods: Subjects (n 78) were rec ..."
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hyperintensities (WMH) in five different brain regions were related to regional PET glucose metabolism (rCMRglc) in cerebral cortex, MRI measures of regional cortical atrophy, and neuropsychological assessment of executive and memory function. Results: WMH was significantly higher in the prefrontal region compared

Original Research Article

by S. Karger Ag, Dement Geriatr, Cogn Disord Extra, White Matter, Hyperintensities Mild, Lewy Body Dementia, C D. Aarsl, O. B. Tysnes, J. T. O’brien, M. K. Beyer
"... Cerebrovascular diseases Cognition Alzheimer’s dementia Lewy body dementia Parkinson’s disease Magnetic resonance imaging White matter hyperintensities Background: The objective of this study was to explore the load of white matter hyperintensi-ties (WMH) in patients with Lewy body dement ..."
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Cerebrovascular diseases Cognition Alzheimer’s dementia Lewy body dementia Parkinson’s disease Magnetic resonance imaging White matter hyperintensities Background: The objective of this study was to explore the load of white matter hyperintensi-ties (WMH) in patients with Lewy body

Quantification and Analysis of Large Multimodal Clinical Image Studies: Application to Stroke

by Ramesh Sridharan, Adrianv. Dalca, Kaitlin M. Fitzpatrick, Lisa Cloonan, Allison Kanakis, Karen L. Furie, Jonathan Ros, Natalia S. Rost, Polina Goll
"... Abstract. We present an analysis framework for large studies of multimodal clinical quality brain image collections. Processing and analysis of such datasets is challenging due to low resolution, poor contrast, misaligned images, and restricted field of view. We adapt existing registration and segme ..."
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the approach on a neuroimaging study of stroke with more than 800 patients. We show that by combining data from several modalities, we can automatically segment important biomarkers such as white matter hyperintensity and characterize pathology evolution in this heterogeneous cohort. Specifically, we examine
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