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WMH White matter hyperintensities

by Aβ Amyloid Beta, Marije R. Benedictus
"... Objectives To investigate arterial spin-labelling (ASL) cere-bral blood flow (CBF) changes in predementia stages of Alzheimer’s disease (AD). Methods Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were b ..."
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based on diagnosis and cerebrospinal fluid bio-markers amyloid-β (Aβ) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex. Results Decreasing CBF was related to more advanced AD stages in all supratentorial

Contrast-Based Fully Automatic Segmentation of White Matter Hyperintensities: Method and Validation

by Thomas Samaille, Ludovic Fillon, Eric Jouvent, Hugues Chabriat, Didier Dormont, Olivier Colliot, Marie Chupin
"... White matter hyperintensities (WMH) on T2 or FLAIR sequences have been commonly observed on MR images of elderly people. They have been associated with various disorders and have been shown to be a strong risk factor for stroke and dementia. WMH studies usually required visual evaluation of WMH load ..."
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load or time-consuming manual delineation. This paper introduced WHASA (White matter Hyperintensities Automated Segmentation Algorithm), a new method for automatically segmenting WMH from FLAIR and T1 images in multicentre studies. Contrary to previous approaches that were based on intensities

Incidental hyperintensities...

by Franz Fazekas, Stefan Ropele, Christian Enzinger, Faton Gorani, Ra Seewann, Katja Petrovic, Reinhold Schmidt, Correspondence To Franz Fazekas
"... The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurolo ..."
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The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198

REVIEW Automatic Detection of White Matter Hyperintensities in Healthy Aging and Pathology Using Magnetic Resonance Imaging: A Review

by Maria Eugenia Caligiuri, Paolo Perrotta, Antonio Augimeri, Federico Rocca, Aldo Quattrone, Andrea Cherubini , 2015
"... # The Author(s) 2015. This article is published with open access at Springerlink.com Abstract White matter hyperintensities (WMH) are commonly seen in the brain of healthy elderly subjects and patients with several neurological and vascular dis-orders. A truly reliable and fully automated method for ..."
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# The Author(s) 2015. This article is published with open access at Springerlink.com Abstract White matter hyperintensities (WMH) are commonly seen in the brain of healthy elderly subjects and patients with several neurological and vascular dis-orders. A truly reliable and fully automated method

Endothelial Function and White Matter Hyperintensities in

by Robert H. Paul, Angela L. Jefferson, Andreana P. Haley, Ronald A. Cohen, Karin F. Hoth, David F. Tate, Daniel E. Forman, John Gunstad, David J. Moser, Karin F. Hoth, Phd David, F. Tate, Md Daniel, E. Forman, Andreana P. Haley, Phd Ronald, A. Cohen
"... The online version of this article, along with updated information and services, is located on the ..."
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The online version of this article, along with updated information and services, is located on the

JOURNAL OF MAGNETIC RESONANCE IMAGING 31:1311–1322 (2010) Original Research Automatic Segmentation of White Matter Hyperintensities in the Elderly Using FLAIR Images at 3T

by Nancy J. Lobaugh , 2009
"... Purpose: To determine the precision and accuracy of an automated method for segmenting white matter hyperintensities (WMH) on fast fluid-attenuated inversion-recovery (FLAIR) images in elderly brains at 3T. Materials and Methods: FLAIR images from 18 individuals (60–82 years, 9 females) with WMH bur ..."
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burdens ranging from 1–80 cm 3 were used. The protocol included the removal of clearly hyperintense voxels; two-class fuzzy C-means clustering (FCM); and thresholding to segment probable WMH. Two false-positive minimization (FPM) methods using white matter templates were tested. Precision was assessed

Current concepts of analysis of cerebral white matter hyperintensities on magnetic resonance imaging

by Mitsuhiro Yoshita, Evan Fletcher, Charles Decarli - Top Magn Reson Imaging , 2005
"... Abstract: Cerebrovascular disease is common and associated with cognitive deficits and increased risk for dementia. Until recently, only limited attention has focused on advances in imaging techniques to better define and quantify the spectrum of asympto-matic cerebrovascular disease commonly seen o ..."
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matter signals commonly referred to as white matter hyperintensities (WMHs) and the association with cerebrovascular risk and cognitive impairment among older individuals make scientific evaluation of WMHs an important and much needed avenue of research. In this section, we review current methods of WMH

Extent and distribution of white matter hyperintensities in normal

by unknown authors
"... Abstract—Objective: To analyze the extent and spatial distribution of white matter hyperintensities (WMH) in brain regions from cognitively normal older individuals (CN) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). Methods: We studied 26 mild AD, 28 MCI, and 33 CN. M ..."
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Abstract—Objective: To analyze the extent and spatial distribution of white matter hyperintensities (WMH) in brain regions from cognitively normal older individuals (CN) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). Methods: We studied 26 mild AD, 28 MCI, and 33 CN

Relationships Between Periventricular WMH, Deep WMH, and Total WMH

by Charles Decarli, Evan Fletcher, Vincent Ramey, Danielle Harvey, William J , 2005
"... located on the World Wide Web at: The online version of this article, along with updated information and services, is ..."
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located on the World Wide Web at: The online version of this article, along with updated information and services, is

Extent and Distribution of White Matter Hyperintensities

by D. M. Mungas, Phd B. R. Reed, Phd C. S. Decarli
"... Disclosure: The authors have reported no conflicts of interest. Acknowledgements: We would like to acknowledge the generosity of our research participants and supporting staff who made this research possible. Address correspondence and reprint requests to: ..."
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Disclosure: The authors have reported no conflicts of interest. Acknowledgements: We would like to acknowledge the generosity of our research participants and supporting staff who made this research possible. Address correspondence and reprint requests to:
Results 1 - 10 of 2,382