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A Compound TCP Approach for High-Speed and Long Distance Networks INFOCOM 2006

by Kun Tan, Jingmin Song, Qian Zhang - in: Proceedings of 25th IEEE International Conference on Computer Communications , 2006
"... Abstract—Many applications require fast data transfer over high speed and long distance networks. However, standard TCP fails to fully utilize the network capacity due to the limitation in its conservative congestion control (CC) algorithm. Some works have been proposed to improve the connection’s t ..."
Abstract - Cited by 111 (3 self) - Add to MetaCart
Abstract—Many applications require fast data transfer over high speed and long distance networks. However, standard TCP fails to fully utilize the network capacity due to the limitation in its conservative congestion control (CC) algorithm. Some works have been proposed to improve the connection’s

Systematic Analysis of Experimental Phenotype Data Reveals Gene Functions

by Robert Hoehndorf, Nigel W. Hardy, David Osumi-sutherl, Susan Tweedie, Paul N. Schofield, Georgios V. Gkoutos , 2013
"... High-throughput phenotyping projects in model organisms have the potential to improve our understanding of gene functions and their role in living organisms. We have developed a computational, knowledge-based approach to automatically infer gene functions from phenotypic manifestations and applied t ..."
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High-throughput phenotyping projects in model organisms have the potential to improve our understanding of gene functions and their role in living organisms. We have developed a computational, knowledge-based approach to automatically infer gene functions from phenotypic manifestations and applied

Network Methods for Pathway Analysis of Genomic Data

by Rosemary Braun, Sahil Shah
"... Rapid advances in high–throughput technologies have led to considerable interest in analyzing genome– scale data in the context of biological pathways, with the goal of identifying functional systems that are involved in a given phenotype. In the most common approaches, biological pathways are model ..."
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Rapid advances in high–throughput technologies have led to considerable interest in analyzing genome– scale data in the context of biological pathways, with the goal of identifying functional systems that are involved in a given phenotype. In the most common approaches, biological pathways

An Application of the Elastic Net for an Endophenotype Analysis

by Dean Palejev , Wookyeon Hwang , Nicole Landi , Maria Eastman , Stephen J Frost , Robert K Fulbright , Judith R Kidd , Kenneth K Kidd , Graeme F Mason , • W Einar Mencl , Carolyn Yrigollen , Kenneth R Pugh , Elena L Grigorenko
"... Abstract We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a criti ..."
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; mean HIGH = .210, SD ALL = .021; and mean LOW = .145, SD ALL = .012, measured as described below). This selection approach improved the power of the association analyses, although the continuous phenotype of GABA concentration was used. The majority of the children were Caucasian, with one child

New Perspectives of “omics ” Applications in Melanoma Research Open Access

by Carmen Rodríguez-cerdeira, Alberto Molares-vila
"... Abstract: Background: Oncoproteomics is the study of proteins and their interactions in a cancer cell by proteomic technologies and has the potential to revolutionize clinical practice, including cancer diagnosis. Recent technological advances in the analysis of the human genome have opened the door ..."
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was performed to determine the role of epigenetic modifications in human melanoma. The role of array-based high-throughput gene expression analysis in understanding the specific genes involved as well as the pathways and the comparative gene expression patterns of primary and metastatic melanoma

Application of genomic tools in plant breeding

by A. M. Pérez-de-castro, S. Vilanova, J. Cañizares, L. Pascual, J. M. Blanca, M. J. Díez, J. Prohens, B. Picó - Curr. Genomics 2012
"... Abstract: Plant breeding has been very successful in developing improved varieties using conventional tools and methodologies. Nowadays, the availability of genomic tools and resources is leading to a new revolution of plant breeding, as they facilitate the study of the genotype and its relationship ..."
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relationship with the phenotype, in particular for complex traits. Next Generation Sequencing (NGS) technologies are allowing the mass sequencing of genomes and transcriptomes, which is producing a vast array of genomic information. The analysis of NGS data by means of bioinformatics developments allows

Genome-Scale Reconstruction and Analysis of the Pseudomonas putida KT2440 Metabolic Network Facilitates Applications in Biotechnology

by Jacek Puchałka, Matthew A. Oberhardt, Miguel Godinho, Agata Bielecka, Daniela Regenhardt, Kenneth N. Timmis, Jason A. Papin
"... A cornerstone of biotechnology is the use of microorganisms for the efficient production of chemicals and the elimination of harmful waste. Pseudomonas putida is an archetype of such microbes due to its metabolic versatility, stress resistance, amenability to genetic modifications, and vast potentia ..."
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from continuous cell cultures, high-throughput phenotyping data, 13 C-measurement of internal flux distributions, and specifically generated knock-out mutants. Auxotrophy was correctly predicted in 75 % of the cases. These systematic analyses revealed that the metabolic network structure is the main

Robust and Sensitive Analysis of Mouse Knockout

by Natasha A. Karp* David Melvin
"... A significant challenge of in-vivo studies is the identification of phenotypes with a method that is robust and reliable. The challenge arises from practical issues that lead to experimental designs which are not ideal. Breeding issues, particularly in the presence of fertility or fecundity problems ..."
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problems, frequently lead to data being collected in multiple batches. This problem is acute in high throughput phenotyping programs. In addition, in a high throughput environment operational issues lead to controls not being measured on the same day as knockouts. We highlight how application

Improving the Performance of Intrusion Detection using Dialog-based Payload Aggregation

by Tobias Limmer, Falko Dressler
"... (DPA) that extracts relevant payload data from TCP/IP packet streams based on sequence numbers in the TCP header for im-proved intrusion detection performance. Typical network-based Intrusion Detection Systems (IDSs) like Snort, which use rules for matching payload data, show severe performance prob ..."
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problems in high-speed networks. Our detailed analysis based on live network traffic reveals that most of the signature matches either occur at the beginning of TCP connections or directly after direction changes in the data streams. Our DPA approach exploits protocol semantics intrinsic to bidirectional

Instrumentation developments iin scanning soft x-ray microscopy at the NSLS (invited) Mark Rivers

by Shawn Williams , Chris Jacobsen , Janos Kirz , ) J&-G Maser , Sue Wirick , Xiaodong Zhang , Harald Ade , Cars
"... The Scanning Transmission Soft X-ray Microscope at the NSLS has been instrumented for the following new forms of imaging: (1) XANES microscopy for the mapping of chemical constituents and for absorption spectroscopy of small specimen areas; (2) luminescence microscopy for locating visible light emi ..."
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by E. Anderson (Center for X-ray Optics, LBL). The Xl soft x-ray undulator serves as the bright tuneable source and the zone plate forms a microprobe that provides the 50 nm resolution of the instrument.' [ Scanning microscopy is among the major beneficiaries of high brightness, in that the
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