Abstract: We have pursued an interdisciplinary research program to develop novel behavioral assessment tools for evalu-ating specific memory impairments following damage to the medial temporal lobe, including the hippocampus and asso-ciated structures that show pathology early in the course

's disease (AD) due to increased structural brain changes, including white matter alteration, and excess age-related brain atrophy [11][12][13][14][15][16]. Various cross-sectional studies find that excess weight is also associated with reduced cognitive function [17][18][19][20][21][22]. Consistent

This report focuses on the evidence about the health.consequences of smoking for women, and is intended to serve.the public health and medical communities as 'a unified source of existing scientific research. The major issues about tobacco use and women's health are examined, including trends in consumption, biomedical evidence, and determinants of smoking ititiation, maintenance, and cessation. The biomedical aspects ofsmoking are presented in terms of mortality, morbiplity, cardiovasculaidiseases, cancer, pregnancy and infant,health,, Teptic ulcer disease, drug reactions and, interactions, food constituents, and responses to,diagnostic tests. The psychosocial and behavioraj. aspects, of smoking in women are discussed, along with the docffiented increases in- the risk of contracting lung cancer, heart,disease, or lung disease. The harmful effects of pregnant mothers smoking behaviors, are also docudented. Adhitionally, recent data are enumerated to indicate a trend of,decreasing tobacco usage among women in response to the warnings of the gavernMent, voluntary agencie, and physicrins. (Author /NRB)' DOCUMENT RESUME cc 015 465

neurosurgical unit. 10 In a recent prospective study, ApoE genotypes were tested for their ability to predict days of unconsciousness and functional outcome after six months. 11 There was a strongassociation demonstrated between the ApoE allele and poor clinical outcome. Furthermore, ApoE deficient (knockout

changed in old age. Perhaps the most significant change is the accumulation of long-lived memory cells and the decline in frequencies of naive cells. Kline et al have used kinetic labeling experiments and demonstrated that peripheral B cells in aged mice have a much longer life span than peripheral B

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article, we noted, "cognitive decline, especially memory deficit associated with aging, is a concern of many Baby Boomers in regard to their parents as well as themselves." We also reviewed the topics of maintaining cognitive abilities, emotional health, and the relationship between religion

. In Italy the mean age of women at childbearing has risen from 27. In their analyses of the decline of the total fertility rate below 1.3-or to lowest-low fertility levels- The study is structured as follows: after a brief description of some empirical evidence in Section 2, Section 3 outlines the existing