Schultz, Wolfram. Predictive reward signal of dopamine neurons. is called rewards, which elicit and reinforce approach behav-J. Neurophysiol. 80: 1–27, 1998. The effects of lesions, receptor ior. The functions of rewards were developed further during blocking, electrical self-stimulation, and drugs

this article contains data set material, and is available at www.molbiolcell.org.

), leading to the assembly of a meshwork of actin filaments at the cell periphery to produce lamellipodia and membrane ruffles (Fig. 1E) (2). More re-cently, activation of Cdc42, a third member of the Rho subfamily, was shown to induce actin-rich surface protrusions called filopo-dia (Fig. 1G) (3, 4

by palmitate or PKR. In summary, PKR mediates the regulation of the protein level and the phosphorylation status of Bcl-2, providing a novel mechanism of palmitate-induced apoptosis in HepG2 cells.

protein kinases, sometimes much more potently than their presumed targets, and conclusions drawn from their use in cell-based experiments are likely to be erroneous. Ro 318220 and related bisindoylmaleimides, as well as H89, HA1077 and Y 27632, were more selective inhibitors, but still inhibited two

mathematically by defining an objective function, a measure of performance for any possi-ble movement. The unique trajectory which yields the best performance is determined using dynamic optimization the-ory. In the work presented here, the objective function is the square of the magnitude of jerk (rate

DNA, RNA, proteins, and small molecules. As most genetic regulatory networks of interest involve many components connected through interlocking positive and negative feedback loops, an intuitive understanding of their dynamics is hard to obtain. As a consequence, formal methods and computer tools

in subsequent simulations, including an attractor network that reproduces the naming latency data directly in its time to settle on a response. Further analyses of the network's ability to reproduce data on impaired reading in surface dyslexia support a view of the reading system that incorporates a graded

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