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A (2006) Genomic imprinting and cancer: from primordial germ cells to somatic cells

by Adele Murrell - ScientificWorldJournal
"... Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic ..."
Abstract - Cited by 7 (0 self) - Add to MetaCart
Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic

Active Mask Framework for Segmentation of Fluorescence Microscope Images

by Gowri Srinivasa, Advisor Prof, Prof Matthew, C. Fickus, Prof Adam, D. Linstedt, Prof Robert, F. Murphy
"... m]]l]]s¶D]]¿÷mB]iv]b]oD]m¶¨]iv]§]iv]r]j]t¿rv]]irj]]t]]m] / | ap]]r¿]ÎNy]s¶D]]mb¶r]ix} Û]Ix]]rd]mb]} p—N]t]o%ism] in]ty]m] / || Û]Is]¡uÎc]rN]]riv]nd]p]*N]m]st¶ I always bow to Śri ̄ Śāradāmbā, the limitless ocean of the nectar of compassion, who bears a rosary, a vessel of nectar, the symbol of ..."
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of knowledge and a book in Her lotus hands. Dedicated to the Lotus Feet of the revered Sadguru. This thesis presents a new active mask (AM) framework and an algorithm for segmenta-tion of digital images, particularly those of punctate patterns from fluorescence microscopy. Fluorescence microscopy has greatly

An emerging role for IQGAP1 in regulating protein traffic

by Mahasin A Osman - ScientificWorldJournal , 2010
"... IQGAP1 , an effector of CDC42p GTPase, is a widely conserved, multifunctional protein that bundles F-actin through its N-terminus and binds microtubules through its Cterminus to modulate the cell architecture. It has emerged as a potential oncogene associated with diverse human cancers. Therefore, ..."
Abstract - Cited by 2 (1 self) - Add to MetaCart
a conserved role for IQGAP1 in protein synthesis and membrane traffic, which may help to explain the diversity of its cellular functions. Membrane traffic mediates infections by intracellular pathogens and a range of degenerative human diseases arise from dysfunctions in intracellular traffic; thus

unknown title

by Brett S Abrahams , Daniel H Geschwind
"... Autistic disorder is the most severe end of a group of neurodevelopmental disorders referred to as autism spectrum disorders (ASDs), which share the common feature of dysfunctional reciprocal social interaction. A meta-analysis of ASD prevalence rates suggests that approximately 37 in 10,000 indivi ..."
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understanding of the genetic factors underlying the ASDs. These approaches include whole-genome and pathway-based association studies, dense resequencing to identify Gene association studies a set of methods that is used to determine the correlation (positive or negative) between a defined genetic variant and a

The past, present, and future of immune repertoire biology—the rise of next-generation repertoire analysis. Front Immunol 4

by Adrien Six , Maria Encarnita Mariotti-Ferrandiz , Wahiba Chaara , Susana Magadan , Hang-Phuong Pham , Marie-Paule Lefranc , Thierry Mora , Véronique Thomas-Vaslin , Aleksandra M Walczak , Pierre Boudinot , Koji Yasutomo , 2013
"... T and B cell repertoires are collections of lymphocytes, each characterized by its antigenspecific receptor. We review here classical technologies and analysis strategies developed to assess immunoglobulin (IG) and T cell receptor (TR) repertoire diversity, and describe recent advances in the field ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
diabetes from non-diabetes individuals. In this way, it was found that the patterns of IgG antibodies expressed early in male NOD mice can mark susceptibility or resistance to diabetes induced later and that it is different than the pattern characteristic of healthy or diabetic mice after disease induction
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