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for Mouse Phenotype Analysis, 3Team for Advanced Development and Evaluation of Human Disease Models, RIKEN

by Nobuhiko Tanaka, Kazunori Waki, Hideki Kaneda, Tomohiro Suzuki, Ikuko Yamada, Tamio Furuse, Kimio Kobayashi, Hiromi Motegi, Hideaki Toki, Maki Inoue, Osamu Minowa, Tetsuo Noda, Keizo Takao, Tsuyoshi Miyakawa, Aki Takahashi, Tsuyoshi Koide, Shigeharu Wakana, Hiroshi Masuya, Martin Bishop , 2009
"... SDOP-DB: a comparative standardized-protocol database for ..."
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SDOP-DB: a comparative standardized-protocol database for

1 Database and ontologies

by Nobuhiko Tanaka, Kazunori Waki, Hideki Kaneda, Tomohiro Suzuki, Ikuko Yamada, Tamio Furuse, Kimio Kobayashi, Hiromi Motegi, Hideaki Toki, Maki Inoue, Osamu Mi
"... SDOP-DB: A comparative standardised-protocol database for mouse phenotypic analyses ..."
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SDOP-DB: A comparative standardised-protocol database for mouse phenotypic analyses

, Kimio Kobayashi 2

by Kazunori Waki, Ikuko Yamada, Hiromi Motegi, Hideaki Toki, Maki Inoue, Osamu Minowa, Keizo Takao, Tsuyoshi Miyakawa, Shigeharu Wakana
"... SDOPDB: comparative standardized-protocol database for mouse phenotyping analyses ..."
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SDOPDB: comparative standardized-protocol database for mouse phenotyping analyses

Databases and ontologies EMPReSS: European Mouse Phenotyping Resource for Standardized Screens

by Eain C. J. Green, Georgios V. Gkoutos, Heena V. Lad, Andrew Blake, Joseph Weekes, John M. Hancock , 2005
"... Summary: Standardized phenotyping protocols are essential for the characterization of phenotypes so that results are comparable between different laboratories and phenotypic data can be related to ontological descriptions in an automated manner. We describe a web-based resource for the visualization ..."
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Summary: Standardized phenotyping protocols are essential for the characterization of phenotypes so that results are comparable between different laboratories and phenotypic data can be related to ontological descriptions in an automated manner. We describe a web-based resource

BIOINFORMATICS APPLICATIONS NOTE Databases and ontologies EMPReSS: European Mouse Phenotyping Resource for Standardized Screens

by Eain C. J. Green, Georgios V. Gkoutos, Heena V. Lad, Andrew Blake, Joseph Weekes, John M. Hancock , 2005
"... Summary: Standardized phenotyping protocols are essential for the characterization of phenotypes so that results are comparable between different laboratories and phenotypic data can be related to ontological descriptions in an automated manner. We describe a web-based resource for the visualization ..."
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Summary: Standardized phenotyping protocols are essential for the characterization of phenotypes so that results are comparable between different laboratories and phenotypic data can be related to ontological descriptions in an automated manner. We describe a web-based resource

N-Enriched Bacteria Diet for Improved Proteomic Analyses of Mouse Models for Psychopathologies

by Elisabeth Frank, Melanie S. Kessler, Michaela D. Filiou, Yaoyang Zhang, Stefan Reckow, Mirjam Bunck, Hermann Heumann, Christoph W. Turck, Rainer L
"... The identification of differentially regulated proteins in animal models of psychiatric diseases is essential for a comprehensive analysis of associated psychopathological processes. Mass spectrometry is the most relevant method for analyzing differences in protein expression of tissue and body flui ..."
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samples allows a sensitive and accurate comparative analysis between the respective proteomes. Here, we describe a cost-effective feeding protocol based on a newly developed 15 N bacteria diet based on Ralstonia eutropha protein, which was applied to a mouse model for trait anxiety. Tissue from 15 N

Original article Manual Gene Ontology annotation workflow at the Mouse Genome Informatics Database

by Harold J. Drabkin, Judith A. Blake, Mouse Genome, Informatics Database
"... both a consensus view and an experimental view of the knowledge concerning the genetics and genomics of the laboratory mouse. From genotype to phenotype, this information resource integrates information about genes, sequences, maps, expression analyses, alleles, strains and mutant phenotypes. Compar ..."
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both a consensus view and an experimental view of the knowledge concerning the genetics and genomics of the laboratory mouse. From genotype to phenotype, this information resource integrates information about genes, sequences, maps, expression analyses, alleles, strains and mutant phenotypes

How closely correlated are molecular and quantitative measures of genetic variation? A meta-analysis.

by David H Reed , Richard Frankham - Evolution , 2001
"... Abstract. The ability of populations to undergo adaptive evolution depends on the presence of quantitative genetic variation for ecologically important traits. Although molecular measures are widely used as surrogates for quantitative genetic variation, there is controversy about the strength of th ..."
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of quantitative genetic variation and molecular measures of genetic variation be quantified. For example, neutral theory is applied to management protocols for endangered species of animals in captivity (Ballou and Lacy 1995). In addition, heterozygosity as measured with molecular markers is used routinely as a

The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data

by unknown authors
"... structured vocabulary for describing mammalian pheno-types and serves as a critical tool for efficient annotation and comprehensive retrieval of phenotype data. Impor-tantly, the ontology contains broad and specific terms, facilitating annotation of data from initial observations or screens and deta ..."
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and variants annotated to the MP already exists in the Mouse Genome Informatics database. These data, along with data curated to the MP by many mouse muta-genesis programs and mouse repositories, provide a plat-form for comparative analyses and correlative discoveries. The MP provides a standard underpinning

BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btm123 Databases and ontologies Management, presentation and interpretation of genome scans using GSCANDB

by Martin Taylor, William Valdar, Ashish Kumar, Jonathan Flint, Richard Mott
"... Motivation: Advances in high-throughput genotyping have made it possible to carry out genome-wide association studies using very high densities of genetic markers. This has led to the problem of the storage, management, quality control, presentation and interpretation of results. In order to achieve ..."
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to achieve a successful outcome, it may be necessary to analyse the data in different ways and compare the results with genome annotations and other genome scans. Results: We created GSCANDB, a database for genome scan data, using a MySQL backend and Perl-CGI web interface. It displays genome scans
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