Thirty-two participants representing parents, funding agencies and clinicians involved in the care of children with

Children’s responses to environmental toxicants will be affected by the way in which their systems absorb, distribute, metabolize, and excrete chemicals. These toxicokinetic factors vary during development, from in utero where maternal and placental processes play a large role, to the neonate in which emerging metabolism and clearance pathways are key determinants. Toxicokinetic differences between neonates and adults lead to the potential for internal dosimetry differences and increased or decreased risk, depending on the mechanisms for toxicity and clearance of a given chemical. This article raises a number of questions that need to be addressed when conducting a toxicokinetic analysis of in utero or childhood exposures. These questions are organized into a proposed framework for conducting the assessment that involves problem formulation (identification of early life stage toxicokinetic factors and chemical-specific factors that may raise questions/concerns for children); data analysis (development of analytic approach, construction of child/adult or child/animal dosimetry comparisons); and risk characterization (evaluation of how children’s toxicokinetic analysis can be used to decrease uncertainties in the risk assessment). The proposed approach provides a range of analytical options, from qualitative to quantitative, for assessing children’s dosimetry. Further, it provides background information on a variety of

www.humanbrainmapping.org/OHBM2012 To view full abstract text and ePosters, visit ww4.aievolution.com/hbm1201POSTER KEY All posters will be displayed for 2 days, either Monday/Tuesday or Wednesday/Thursday. For Monday and Tuesday posters, even numbered posters will stand-by on Monday, June 11 and odd numbered posters will stand-by on Tuesday, June 12. For Wednesday and Thursday posters, even numbered posters will stand-by on Wednesday, June 13 and odd numbered posters will stand-by on Thursday, June 14. See daily poster stand-by session times below. Daily Poster Stand-By Session Times Monday, June 11: 13:30 – 15:30 (even numbers)

This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon,