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Asymmetry in Functional Connectivity of the Human Habenula Revealed by High-Resolution Cardiac-Gated Resting State Imaging

by S Ebastien , H Etu , Yi Luo , Ignacio Saez , Kimberlee D'ardenne , Terry Lohrenz , P Read Montague
"... Abstract: The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relat ..."
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' habenula, we show that the habenula is functionally coupled with the insula, parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we

An Approach for Identifying Brainstem Dopaminergic Pathways Using Resting State Functional MRI

by Jason Vytlacil, Andrew Kayser, Asako Miyakawa , 2014
"... Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal regio ..."
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Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal

ORIGINAL RESEARCH Functional Connectivity of the Human Red Nucleus in the Brain Resting State at 3T

by C. Nioche, E. A. Cabanis, C. Habas
"... BACKGROUND AND PURPOSE: Previous structural data obtained with diffusion tensor imaging axonal tracking have demonstrated possible in vivo connections between the human red nucleus (RN) and the sensorimotor and associative cortical areas. However, tractographic reconstructions can include false traj ..."
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trajectories because of, for instance, the low spatial resolution of diffusion images or the inability to precisely detect fiber crossings. The rubral network was therefore reassessed by functional connec-tivity during the brain resting state. Because the RN is located very close to the substantia nigra (SN

Mesolimbic novelty processing in older adults. Cereb Cortex 17:2940–2948

by Nico Bunzeck, Hartmut Schütze, Sabine Stallforth, Jo Rn, Hans-jochen Heinze - Duzel S, Heinze HJ, Duzel E , 2007
"... Normal aging is associated with neuronal loss in the dopaminergic midbrain (substantia nigra/ventral tegmental area, SN/VTA), a region that has recently been implicated in processing novel stimuli as part of a mesolimbic network including the hippocampus. Here, we quantified age-related structural d ..."
Abstract - Cited by 5 (3 self) - Add to MetaCart
Normal aging is associated with neuronal loss in the dopaminergic midbrain (substantia nigra/ventral tegmental area, SN/VTA), a region that has recently been implicated in processing novel stimuli as part of a mesolimbic network including the hippocampus. Here, we quantified age-related structural

This work...

by In The Human Striatum, Dopaminergic Midbrain, Marc Guitart-masip, Lluis Fuentemilla, Dominik R. Bach, Quentin J. M. Huys, Peter Dayan, Raymond J. Dolan, Emrah Duzel , 2010
"... The acquisition of reward and the avoidance of punishment could logically be contingent on either emitting or withholding particular actions. However, the separate pathways in the striatum for go and no-go appear to violate this independence, instead coupling affect and effect. Respect for this inte ..."
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independent from subsequent receipt of reward or avoidance of punishment. During anticipation, in the striatum and a lateral region within the substantia nigra/ventral tegmental area (SN/VTA), action representations dominated over valence representations. Moreover, we did not observe any representation

This work...

by In The Human Striatum, Dopaminergic Midbrain, Marc Guitart-masip, Lluis Fuentemilla, Dominik R. Bach, Quentin J. M. Huys, Peter Dayan, Raymond J. Dolan, Emrah Duzel , 2010
"... The acquisition of reward and the avoidance of punishment could logically be contingent on either emitting or withholding particular actions. However, the separate pathways in the striatum for go and no-go appear to violate this independence, instead coupling affect and effect. Respect for this inte ..."
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independent from subsequent receipt of reward or avoidance of punishment. During anticipation, in the striatum and a lateral region within the substantia nigra/ventral tegmental area (SN/VTA), action representations dominated over valence representations. Moreover, we did not observe any representation

A model of basal ganglia function unifying reinforcement learning and action selection

by Gregory S. Berns, Terrence J. Sejnowski - Joint Symposium on Neural Computation , 1995
"... We propose a systems-level computational model of the basal gangha based closely on known anatomy and physiology. First, we assume that thalamic output &argets of the basal ganglia, which relay ascending information to cortical action and planning areas, are tonically inhibited. Second, we assum ..."
Abstract - Cited by 3 (0 self) - Add to MetaCart
in implementing a "winner-lose-all " in the globus pallidus, which selects thalamic targets by disinhibition. We combine this winner-selection mechanism with reinforcement learning through dopaminergic neurons in the substantia nigra and the ventral tegmental area to m ow the cortico-striatal synapse

Brain networks underlying episodic memory retrieval

by Michael D Rugg , Kaia L Vilberg - Current Opinion in Neurobiology , 2013
"... The importance of the medial temporal lobe to episodic memory has been recognized for decades. Recent human fMRI findings have begun to delineate the functional roles of different MTL regions, most notably the hippocampus, for the retrieval of episodic memories. Importantly, these studies have also ..."
Abstract - Cited by 5 (0 self) - Add to MetaCart
of resting state connectivity similar to that shown in humans Based largely on fMRI evidence, a number of proposals have been advanced regarding the functional significance of recollection-related activity in the angular gyrus. According to one idea A general recollection network? As it was just reviewed

Behavioral/Cognitive Associative Encoding and Retrieval Are Predicted by Functional Connectivity in Distinct Hippocampal Area CA1 Pathways

by Katherine Duncan , Alexa Tompary , Lila Davachi
"... Determining how the hippocampus supports the unique demands of memory encoding and retrieval is fundamental for understanding the biological basis of episodic memory. One possibility proposed by theoretical models is that the distinct computational demands of encoding and retrieval are accommodated ..."
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)], medial temporal lobe (MTL) cortical regions (entorhinal cortex, perirhinal cortex, and parahippocampal cortex), and dopaminergic midbrain structures (VTA and substantia nigra). It should be noted that data from the entorhinal cortex were excluded from analyses because this area suffered from dropout

unknown title

by Maryka Quik , J Michael Mcintosh , Cui C , Booker Tk , Allen Rs , Grady Sr , Whiteaker P , Marks Mj , Salminen O , Butt CM, Tritto T , Allen Wr , Stitzel Ja , Mcintosh Jm , Boulter J , Collins Ac , Heinemann Sf
"... University of . Number of words in abstract, 222. ABBREVIATIONS: Abbreviations: nAChR, nicotinic acetylcholine receptor; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; *denotes nAChRs containing the indicated α and/or β subunit and also additional undefined subunits. JPET #94375 PiP 3 ABSTRACT ..."
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* receptors also have high affinity for methyllycaconitine, a plant alkaloid historically considered selective for α7 nAChRs. Putative α6α4α5β2 nAChRs present on dopamine neurons in rat substantia nigra and ventral tegmental area are completely inhibited by 1 nM methyllycaconitine (Klink et al., 2001
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