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The Nature of Statistical Learning Theory
, 1999
"... Statistical learning theory was introduced in the late 1960’s. Until the 1990’s it was a purely theoretical analysis of the problem of function estimation from a given collection of data. In the middle of the 1990’s new types of learning algorithms (called support vector machines) based on the deve ..."
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Cited by 12976 (32 self)
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Statistical learning theory was introduced in the late 1960’s. Until the 1990’s it was a purely theoretical analysis of the problem of function estimation from a given collection of data. In the middle of the 1990’s new types of learning algorithms (called support vector machines) based
Maximum likelihood from incomplete data via the EM algorithm
 JOURNAL OF THE ROYAL STATISTICAL SOCIETY, SERIES B
, 1977
"... A broadly applicable algorithm for computing maximum likelihood estimates from incomplete data is presented at various levels of generality. Theory showing the monotone behaviour of the likelihood and convergence of the algorithm is derived. Many examples are sketched, including missing value situat ..."
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Cited by 11807 (17 self)
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situations, applications to grouped, censored or truncated data, finite mixture models, variance component estimation, hyperparameter estimation, iteratively reweighted least squares and factor analysis.
Probabilistic Principal Component Analysis
 Journal of the Royal Statistical Society, Series B
, 1999
"... Principal component analysis (PCA) is a ubiquitous technique for data analysis and processing, but one which is not based upon a probability model. In this paper we demonstrate how the principal axes of a set of observed data vectors may be determined through maximumlikelihood estimation of paramet ..."
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Cited by 703 (5 self)
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Principal component analysis (PCA) is a ubiquitous technique for data analysis and processing, but one which is not based upon a probability model. In this paper we demonstrate how the principal axes of a set of observed data vectors may be determined through maximumlikelihood estimation
Mixtures of Probabilistic Principal Component Analysers
, 1998
"... Principal component analysis (PCA) is one of the most popular techniques for processing, compressing and visualising data, although its effectiveness is limited by its global linearity. While nonlinear variants of PCA have been proposed, an alternative paradigm is to capture data complexity by a com ..."
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Cited by 537 (6 self)
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Principal component analysis (PCA) is one of the most popular techniques for processing, compressing and visualising data, although its effectiveness is limited by its global linearity. While nonlinear variants of PCA have been proposed, an alternative paradigm is to capture data complexity by a
Nonlinear component analysis as a kernel eigenvalue problem

, 1996
"... We describe a new method for performing a nonlinear form of Principal Component Analysis. By the use of integral operator kernel functions, we can efficiently compute principal components in highdimensional feature spaces, related to input space by some nonlinear map; for instance the space of all ..."
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Cited by 1554 (85 self)
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We describe a new method for performing a nonlinear form of Principal Component Analysis. By the use of integral operator kernel functions, we can efficiently compute principal components in highdimensional feature spaces, related to input space by some nonlinear map; for instance the space of all
The "Independent Components" of Natural Scenes are Edge Filters
, 1997
"... It has previously been suggested that neurons with line and edge selectivities found in primary visual cortex of cats and monkeys form a sparse, distributed representation of natural scenes, and it has been reasoned that such responses should emerge from an unsupervised learning algorithm that attem ..."
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Cited by 620 (29 self)
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. Some of these filters are Gaborlike and resemble those produced by the sparsenessmaximization network. In addition, the outputs of these filters are as independent as possible, since this infomax network performs Independent Components Analysis or ICA, for sparse (supergaussian) component
On Bayesian analysis of mixtures with an unknown number of components
 INSTITUTE OF INTERNATIONAL ECONOMICS PROJECT ON INTERNATIONAL COMPETITION POLICY,&QUOT; COM/DAFFE/CLP/TD(94)42
, 1997
"... ..."
Segmentation of brain MR images through a hidden Markov random field model and the expectationmaximization algorithm
 IEEE TRANSACTIONS ON MEDICAL. IMAGING
, 2001
"... The finite mixture (FM) model is the most commonly used model for statistical segmentation of brain magnetic resonance (MR) images because of its simple mathematical form and the piecewise constant nature of ideal brain MR images. However, being a histogrambased model, the FM has an intrinsic limi ..."
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Cited by 619 (14 self)
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The finite mixture (FM) model is the most commonly used model for statistical segmentation of brain magnetic resonance (MR) images because of its simple mathematical form and the piecewise constant nature of ideal brain MR images. However, being a histogrambased model, the FM has an intrinsic limitation—no spatial information is taken into account. This causes the FM model to work only on welldefined images with low levels of noise; unfortunately, this is often not the the case due to artifacts such as partial volume effect and bias field distortion. Under these conditions, FM modelbased methods produce unreliable results. In this paper, we propose a novel hidden Markov random field (HMRF) model, which is a stochastic process generated by a MRF whose state sequence cannot be observed directly but which can be indirectly estimated through observations. Mathematically, it can be shown that the FM model is a degenerate version of the HMRF model. The advantage of the HMRF model derives from the way in which the spatial information is encoded through the mutual influences of neighboring sites. Although MRF modeling has been employed in MR image segmentation by other researchers, most reported methods are limited to using MRF as a general prior in an FM modelbased approach. To fit the HMRF model, an EM algorithm is used. We show that by incorporating both the HMRF model and the EM algorithm into a HMRFEM framework, an accurate and robust segmentation can be achieved. More importantly, the HMRFEM framework can easily be combined with other techniques. As an example, we show how the bias field correction algorithm of Guillemaud and Brady (1997) can be incorporated into this framework to achieve a threedimensional fully automated approach for brain MR image segmentation.
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