Results 1  10
of
257,487
Open Access
"... NineML – a description language for spiking neuron network modeling: the user layer ..."
Abstract
 Add to MetaCart
NineML – a description language for spiking neuron network modeling: the user layer
Probabilistic Visual Learning for Object Representation
, 1996
"... We present an unsupervised technique for visual learning which is based on density estimation in highdimensional spaces using an eigenspace decomposition. Two types of density estimates are derived for modeling the training data: a multivariate Gaussian (for unimodal distributions) and a Mixtureof ..."
Abstract

Cited by 705 (15 self)
 Add to MetaCart
We present an unsupervised technique for visual learning which is based on density estimation in highdimensional spaces using an eigenspace decomposition. Two types of density estimates are derived for modeling the training data: a multivariate Gaussian (for unimodal distributions) and a MixtureofGaussians model (for multimodal distributions). These probability densities are then used to formulate a maximumlikelihood estimation framework for visual search and target detection for automatic object recognition and coding. Our learning technique is applied to the probabilistic visual modeling, detection, recognition, and coding of human faces and nonrigid objects such as hands.
A fast and high quality multilevel scheme for partitioning irregular graphs
 SIAM JOURNAL ON SCIENTIFIC COMPUTING
, 1998
"... Recently, a number of researchers have investigated a class of graph partitioning algorithms that reduce the size of the graph by collapsing vertices and edges, partition the smaller graph, and then uncoarsen it to construct a partition for the original graph [Bui and Jones, Proc. ..."
Abstract

Cited by 1173 (16 self)
 Add to MetaCart
Recently, a number of researchers have investigated a class of graph partitioning algorithms that reduce the size of the graph by collapsing vertices and edges, partition the smaller graph, and then uncoarsen it to construct a partition for the original graph [Bui and Jones, Proc.
A simple method for displaying the hydropathic character of a protein
 Journal of Molecular Biology
, 1982
"... A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised. For this purpose, a hydropathy scale has been composed wherein the hydrophilic and hydrophobic properties of each of the 20 amino acid sidechains is tak ..."
Abstract

Cited by 2249 (2 self)
 Add to MetaCart
A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised. For this purpose, a hydropathy scale has been composed wherein the hydrophilic and hydrophobic properties of each of the 20 amino acid sidechains is taken into consideration. The scale is based on an amalgam of experimental observations derived from the literature. The program uses a movingsegment approach that continuously determines the average hydropathy within a segment of predetermined length as it advances through the sequence. The consecutive scores are plotted from the amino to the carboxy terminus. At the same time, a midpoint line is printed that corresponds to the grand average of the hydropathy of the amino acid compositions found in most of the sequenced proteins. In the case of soluble, globular proteins there is a remarkable correspondence between the interior portions of their sequence and the regions appearing on the hydrophobic side of the midpoint line, as well as the exterior portions and the regions on the hydrophilic side. The correlation was demonstrated by comparisons between the plotted values and known structures determined by crystallography. In the case of membranebound proteins, the portions of their sequences that are located within the lipid bilayer are also clearly delineated by large uninterrupted areas on the hydrophobic side of the midpoint line. As such, the membranespanning segment’s of these proteins can be identified by this procedure. Although the method is not unique and embodies principles that have long been appreciated, its simplicity and its graphic nature make it a very useful tool for the evaluation of protein structures. 1.
The use of the area under the ROC curve in the evaluation of machine learning algorithms
 Pattern Recognition
, 1997
"... AbstractIn this paper we investigate the use of the area under the receiver operating characteristic (ROC) curve (AUC) as a performance measure for machine learning algorithms. As a case study we evaluate six machine learning algorithms (C4.5, Multiscale Classifier, Perceptron, Multilayer Percept ..."
Abstract

Cited by 664 (3 self)
 Add to MetaCart
AbstractIn this paper we investigate the use of the area under the receiver operating characteristic (ROC) curve (AUC) as a performance measure for machine learning algorithms. As a case study we evaluate six machine learning algorithms (C4.5, Multiscale Classifier, Perceptron, Multilayer Perceptron, kNearest Neighbours, and a Quadratic Discriminant Function) on six "real world " medical diagnostics data sets. We compare and discuss the use of AUC to the more conventional overall accuracy and find that AUC exhibits a number of desirable properties when compared to overall accuracy: increased sensitivity in Analysis of Variance (ANOVA) tests; a standard error that decreased as both AUC and the number of test samples increased; decision threshold independent; and it is invariant to a priori class probabilities. The paper concludes with the recommendation that AUC be used in preference to overall accuracy for "single number " evaluation of machine
Closedform solution of absolute orientation using unit quaternions
 J. Opt. Soc. Am. A
, 1987
"... Finding the relationship between two coordinate systems using pairs of measurements of the coordinates of a number of points in both systems is a classic photogrammetric task. It finds applications in stereophotogrammetry and in robotics. I present here a closedform solution to the leastsquares pr ..."
Abstract

Cited by 973 (4 self)
 Add to MetaCart
Finding the relationship between two coordinate systems using pairs of measurements of the coordinates of a number of points in both systems is a classic photogrammetric task. It finds applications in stereophotogrammetry and in robotics. I present here a closedform solution to the leastsquares problem for three or more points. Currently various empirical, graphical, and numerical iterative methods are in use. Derivation of the solution is simplified by use of unit quaternions to represent rotation. I emphasize a symmetry property that a solution to this problem ought to possess. The best translational offset is the difference between the centroid of the coordinates in one system and the rotated and scaled centroid of the coordinates in the other system. The best scale is equal to the ratio of the rootmeansquare deviations of the coordinates in the two systems from their respective centroids. These exact results are to be preferred to approximate methods based on measurements of a few selected points. The unit quaternion representing the best rotation is the eigenvector associated with the most positive eigenvalue of a symmetric 4 X 4 matrix. The elements of this matrix are combinations of sums of products of corresponding coordinates of the points. 1.
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. sect
 A
, 1991
"... Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallographic refinement and result in an incorrect structure. The normally quoted crystallographic residual is often a poor description for the q ..."
Abstract

Cited by 1016 (9 self)
 Add to MetaCart
Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallographic refinement and result in an incorrect structure. The normally quoted crystallographic residual is often a poor description for the quality of the model. Strategies and tools are described that help to alleviate this problem. These simplify the modelbuilding process, quantify the goodness of fit of the model on a perresidue basis and locate possible errors in peptide and sidechain conformations.
Functional discovery via a compendium of expression profiles. Cell 102:109
, 2000
"... have been devised to survey gene functions en masse either computationally (Marcotte et al., 1999) or experimentally; among these, highly parallel assays of ..."
Abstract

Cited by 537 (8 self)
 Add to MetaCart
have been devised to survey gene functions en masse either computationally (Marcotte et al., 1999) or experimentally; among these, highly parallel assays of
Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol. Rev
, 1995
"... cultivation.of individual microbial cells without Phylogenetic identification and in situ detection ..."
Abstract

Cited by 1070 (29 self)
 Add to MetaCart
cultivation.of individual microbial cells without Phylogenetic identification and in situ detection
Predicting How People Play Games: Reinforcement Learning . . .
 AMERICAN ECONOMIC REVIEW
, 1998
"... ..."
Results 1  10
of
257,487