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Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange

by Michele Vendruscolo, Emanuele Paci, Christopher M. Dobson, Martin Karplus - J. Amer. Chem. Soc
"... Equilibrium hydrogen-exchange measurements are a powerful tool for investigating the structures, stabilities, and dynamics of native and nonnative states of proteins.1-4 Previous analyses of hydrogen-exchange data have provided considerable insight into such properties for a variety of proteins, but ..."
Abstract - Cited by 5 (1 self) - Add to MetaCart
Equilibrium hydrogen-exchange measurements are a powerful tool for investigating the structures, stabilities, and dynamics of native and nonnative states of proteins.1-4 Previous analyses of hydrogen-exchange data have provided considerable insight into such properties for a variety of proteins

Hydrogen-deuterium exchange as a probe of folding and assembly in viral capsids

by Roman Tuma , Lori U Coward , Marion C Kirk , Stephen Barnes , Peter E Prevelige Jr - J Mol Biol , 2001
"... The dynamics of proteins within large cellular assemblies are important in the molecular transformations that are required for macromolecular synthesis, transport, and metabolism. The capsid expansion (maturation) accompanying DNA packaging in the dsDNA bacteriophage P22 represents an experimentall ..."
Abstract - Cited by 6 (0 self) - Add to MetaCart
dynamics irrespective of the size of the assembly. Partial digestion of the exchanged protein with pepsin allows for region-speci®c assignment of the exchange. Procapsids and mature capsids were probed under native and slightly denaturing conditions. These experiments revealed regions that exhibit

OneG: A Computational Tool for Predicting Cryptic Intermediates in the Unfolding Kinetics of Proteins under Native Conditions

by Tambi Richa, Thirunavukkarasu Sivaraman
"... Understanding the relationships between conformations of proteins and their stabilities is one key to address the protein folding paradigm. The free energy change (DG) of unfolding reactions of proteins is measured by traditional denaturation methods and native hydrogen-deuterium (H/D) exchange meth ..."
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Understanding the relationships between conformations of proteins and their stabilities is one key to address the protein folding paradigm. The free energy change (DG) of unfolding reactions of proteins is measured by traditional denaturation methods and native hydrogen-deuterium (H/D) exchange

Identification of initiation sites for T4 lysozyme folding using CD and NMR spectroscopy of peptide fragments

by Lidia V Najbar , David J Craik , John D Wade , Michael J Mcleish - Biochemistry , 2000
"... ABSTRACT: Using CD and 2D 1 H NMR spectroscopy, we have identified potential initiation sites for the folding of T4 lysozyme by examining the conformational preferences of peptide fragments corresponding to regions of secondary structure. CD spectropolarimetry showed most peptides were unstructured ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
, by stopped-flow CD 1 experiments and pulsed hydrogen-exchange methods combined with two-dimensional NMR spectroscopy, that many proteins fold via at least partially structured intermediates, referred to as "molten globules" (1-3). These partially folded states are characterized by substantial

Rattling the cage: computational models of chaperoninmediated protein folding

by Jeremy England , Del Lucent , Vijay Pande , Chandra Verma , Juan Fernandez , Recio , 2008
"... Chaperonins are known to maintain the stability of the proteome by facilitating the productive folding of numerous misfolded or aggregation-prone proteins and are thus essential for cell viability. Despite their established importance, the mechanism by which chaperonins facilitate protein folding r ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
EL in prokaryotes, TRiC in eukaryotes, and the thermosome in archaea). Chaperonins are responsible for binding and encapsulating non-native proteins, thereby helping them to reach their functional conformations. It is estimated that 10% of cytosolic proteins interact with chaperonins [1 ,2 ], and in prokaryotes

Protein folding in the cell: challenges and progress.

by Anne Gershenson , Lila M Gierasch , Lila M Gierasch , Michael Gilson , Sheena Radford - Curr. Opin. Struct. Biol. , 2011
"... It is hard to imagine a more extreme contrast than that between the dilute solutions used for in vitro studies of protein folding and the crowded, compartmentalized, sticky, spatially inhomogeneous interior of a cell. This review highlights recent research exploring protein folding in the cell with ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
(specifically, bovine pancreatic ribonuclease A) could refold to an active enzyme after reductive denaturation. Naturally, ribonuclease became emblematic of the fundamental tenet of protein folding -that the primary sequence of a protein specifies an energy landscape and a successful route to the native state

COSMOLOGICAL MODELS OF MODIFIED GRAVITY

by Jolyon Keith Bloomfield, Ph. D , 2013
"... The recent discovery of dark energy has prompted an investigation of ways in which the accelerated expansion of the universe can be realized. In this dissertation, we present two separate projects related to dark energy. The first project analyzes a class of braneworld models in which multiple brane ..."
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The recent discovery of dark energy has prompted an investigation of ways in which the accelerated expansion of the universe can be realized. In this dissertation, we present two separate projects related to dark energy. The first project analyzes a class of braneworld models in which multiple branes float in a five-dimensional anti-de Sitter bulk, while the second investigates a class of dark energy models from an effective field theory perspective. Investigations of models including extra dimensions have led to modifications of gravity involving a number of interesting features. In particular, the Randall-Sundrum model is well-known for achieving an amelioration of the hierarchy problem. However, the basic model relies on Minkowski branes and is subject to solar system constraints in the absence of a radion stabilization mechanism. We present a method by which a four-dimensional low-energy description can be obtained for braneworld scenarios, allowing for a number of generalizations to the original models. This method is applied to orbifolded and uncompactified N-brane models, deriving an effective four-dimensional action. The parameter space of this theory is constrained using observational evidence, and it is found that the generalizations do not weaken solar system constraints on the original model. Furthermore, we find that general

The diverse and expanding role of mass spectrometry in structural and molecular biology Prelude-The coming of age of biomolecular mass spectrometry

by Philip Lössl , Michiel Van De Waterbeemd , Albert Jr Heck
"... Abstract The emergence of proteomics has led to major technological advances in mass spectrometry (MS). These advancements not only benefitted MS-based high-throughput proteomics but also increased the impact of mass spectrometry on the field of structural and molecular biology. Here, we review how ..."
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how state-of-the-art MS methods, including native MS, top-down protein sequencing, cross-linking-MS, and hydrogen-deuterium exchange-MS, nowadays enable the characterization of biomolecular structures, functions, and interactions. In particular, we focus on the role of mass spectrometry in integrated

BDRS PRICE DESCRIPTOR,

by unknown authors
"... This report focuses on the evidence about the health.consequences of smoking for women, and is intended to serve.the public health and medical communities as 'a unified source of existing scientific research. The major issues about tobacco use and women's health are examined, including tre ..."
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This report focuses on the evidence about the health.consequences of smoking for women, and is intended to serve.the public health and medical communities as 'a unified source of existing scientific research. The major issues about tobacco use and women's health are examined, including trends in consumption, biomedical evidence, and determinants of smoking ititiation, maintenance, and cessation. The biomedical aspects ofsmoking are presented in terms of mortality, morbiplity, cardiovasculaidiseases, cancer, pregnancy and infant,health,, Teptic ulcer disease, drug reactions and, interactions, food constituents, and responses to,diagnostic tests. The psychosocial and behavioraj. aspects, of smoking in women are discussed, along with the docffiented increases in- the risk of contracting lung cancer, heart,disease, or lung disease. The harmful effects of pregnant mothers smoking behaviors, are also docudented. Adhitionally, recent data are enumerated to indicate a trend of,decreasing tobacco usage among women in response to the warnings of the gavernMent, voluntary agencie, and physicrins. (Author /NRB)' DOCUMENT RESUME cc 015 465

unknown title

by Helena Susana, Afonso Alves, Helena Susana, Afonso Alves , 2011
"... Corporate Governance determinants of voluntary disclosure and its effects on information asymmetry: an analysis for Iberian Peninsula listed companies. ..."
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Corporate Governance determinants of voluntary disclosure and its effects on information asymmetry: an analysis for Iberian Peninsula listed companies.
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