Results 1 - 10 of 46

Sensitivity and Specificity of Medial Temporal Lobe Visual Ratings and Multivariate Regional MRI Classification in Alzheimer’s Disease

by Eric Westman, Lena Cavallin, J-sebastian Muehlboeck, Yi Zhang, Patrizia Mecocci, Magda Tsolaki, Iwona Kłoszewska, Hilkka Soininen, Christian Spenger, Simon Lovestone, Andrew Simmons, Lars-olof Wahlund
"... Background: Visual assessment rating scales for medial temporal lobe (MTL) atrophy have been used by neuroradiologists in clinical practice to aid the diagnosis of Alzheimer’s disease (AD). Recently multivariate classification methods for magnetic resonance imaging (MRI) data have been suggested as ..."
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Background: Visual assessment rating scales for medial temporal lobe (MTL) atrophy have been used by neuroradiologists in clinical practice to aid the diagnosis of Alzheimer’s disease (AD). Recently multivariate classification methods for magnetic resonance imaging (MRI) data have been suggested

Magnetization transfer measurements of the hippocampus in the early diagnosis of Alzheimer’s disease

by Haruo Hanyu, Tetsuichi Asano, Toshihiko Iwamoto, Masaru Takasaki, Hiroaki Shindo, Kimihiko Abe - J Neurol Sci
"... BACKGROUND AND PURPOSE: Although atrophy of structures in the medial temporal lobe has been considered an indication of Alzheimer’s disease (AD), atrophic changes on MR images have also been associated with other dementing diseases and are not specific to AD. This study was undertaken to determine w ..."
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BACKGROUND AND PURPOSE: Although atrophy of structures in the medial temporal lobe has been considered an indication of Alzheimer’s disease (AD), atrophic changes on MR images have also been associated with other dementing diseases and are not specific to AD. This study was undertaken to determine

NUCLEAR NEUROLOGY MRI-Guided SPECT Measurements of Medial Temporal Lobe Blood Flow in Alzheimer's Disease

by Per Julin, Johan Lindqvist, Leif Svensson, Piotr Slomka, Lars Olof Wahlund
"... In this study, we assessed the accuracy and reliability of MRI-guided SPECT measurements of medial temporal lobe blood flow in Alzheimer's disease (AD). Methods: Interactively aligned three-dimen sional MP-RAGE MRI and "^c-HMPAO SPECT images were used for MRI-guided measurement of medial t ..."
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is possible by this methodology, which might improve the early diag nosis of AD. Key Words: magnetic resonance imaging; SPECT; temporal lobe; cerebral blood flow; brain atrophy; Alzheimer's disease

Dynamics of gray matter loss in Alzheimer’s disease

by Paul M. Thompson, Kiralee M. Hayashi, Greig De Zubicaray, Andrew L. Janke, Stephen E. Rose, James Semple, David Herman, Michael S. Hong, Stephanie S. Dittmer, David M. Doddrell, Arthur W. Toga - Journal of Neuroscience , 2003
"... We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer’s disease (AD). The loss pattern was visualized in four dimensions as it spread over time from temporal and limbic cortices into frontal and occipital brain regions, sparing sensorimotor ..."
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cortices. The shifting deficits were asymmetric (left hemisphere � right hemisphere) and correlated with progressively declining cognitive status ( p � 0.0006). Novel brain mapping methods allowed us to visualize dynamic patterns of atrophy in 52 high-resolution magnetic resonance image scans of 12

Detection of Entorhinal Layer II Using Tesla Magnetic Resonance Imaging

by Jean C. Augustinack, Megan L. Blackwell, Graham C. Wiggins, D. Phil, Andreas Potthast, Lawrence L. Wald, Bruce R. Fischl
"... The entorhinal cortex lies in the mediotemporal lobe and has major functional, structural, and clinical significance. The entorhinal cortex has a unique cytoarchitecture with large stellate neurons in layer II that form clusters. The entorhinal cortex receives vast sensory association input, and its ..."
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ground for high-resolution in vivo scanning that could ultimately benefit early diagnosis and treatment of neurodegenerative disease. Ann Neurol 2005;57:489–494 The entorhinal cortex (EC) lies in the mediotemporal lobe and it has major cytoarchitectural, functional, and

Research Article High-Dimensional Medial Lobe Morphometry: An Automated MRI Biomarker for the New AD Diagnostic Criteria

by Simon Duchesne, O Valdivia, Abderazzak Mouiha, Nicolas Robitaille
"... Copyright © 2014 Simon Duchesne et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Medial temporal lobe atrophy ass ..."
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assessment via magnetic resonance imaging (MRI) has been proposed in recent criteria as an in vivo diagnostic biomarker of Alzheimer’s disease (AD). However, practical application of these criteria in a clinical setting will require automatedMRI analysis techniques. To this end, we wished to validate our

Event-related Potential Magnetic Resonance Imaging Multimodal Imaging Schizophrenia

by Robert W. Mccarley, Motoaki Nakamura, Martha E. Shenton, Dean F. Salisbury , 2008
"... The electrical activity in the electroencephalogram (EEG) and the event-related potentials extracted from the EEG provide the greatest temporal resolution for examining brain function. When coupled with the high spatial resolution of structural magnetic resonance imaging (sMRI), the combined techniq ..."
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The electrical activity in the electroencephalogram (EEG) and the event-related potentials extracted from the EEG provide the greatest temporal resolution for examining brain function. When coupled with the high spatial resolution of structural magnetic resonance imaging (sMRI), the combined

REVIEW PAPER Functional Alterations in Memory Networks in Early Alzheimer’s Disease

by Patrizia Vannini, Peter S. Laviolette, Ottavio V. Vitolo, Trey Hedden, J. Alex, Becker Dorene, M. Rentz, Dennis J. Selkoe, Keith A. Johnson , 2009
"... Abstract The hallmark clinical symptom of early Alz-heimer’s disease (AD) is episodic memory impairment. Recent functional imaging studies suggest that memory function is subserved by a set of distributed networks, which include both the medial temporal lobe (MTL) sys-tem and the set of cortical reg ..."
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Abstract The hallmark clinical symptom of early Alz-heimer’s disease (AD) is episodic memory impairment. Recent functional imaging studies suggest that memory function is subserved by a set of distributed networks, which include both the medial temporal lobe (MTL) sys-tem and the set of cortical

Magnetic resonance spectroscopy and its applications in psychiatry

by Gin S Malhi , Michael Valenzuela , Wei Wen , Perminder Sachdev , Michael Valenzuela , Wei Wen , Perminder Sachdev - Aust N Z J Psychiatry , 2002
"... Over the past two decades, many sophisticated techniques for imaging the brain have been developed and introduced into clinical practice [1, Magnetic resonance spectroscopy is a non-invasive computerized imaging technique that relies on the same nuclear magnetic resonance (NMR) principles that form ..."
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be used to define the nature and extent of brain diseases, such as cancer, stroke and various neurodegenerative disorders, aiding diagnosis and management Basic principles of magnetic resonance spectroscopy Nuclear magnetic resonance exploits the fact that atomic nuclei 'spin' and that spinning

Unit 3 Alzheimer’s Dementia Alzheimer’s Disease

by unknown authors
"... Alzheimer’s disease (AD) is the most common cause of dementia, and the number of affected individuals in the world population is near epidemic proportions,1 more than 35 million people. Epidemi-ologists predict a doubling of patients every 20 years, thus by 2050 the number affected will soar to 115 ..."
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-drocephalus and to detect disease-associated atrophy in the medial temporal lobe and amygdalohippocampal system.4 Increasingly, physicians are using biomarker data to make the diagnosis, and when paired with behavioral data, accuracy is high. Diagnostic Criteria for AD In 2011 a collaborative effort between the Alzheimer’s
Results 1 - 10 of 46