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Practice-based evidence: profiling the safety of cilostazol by text-mining of clinical notes. PLoS ONE

by Nicholas J. Leeper, Anna Bauer-mehren, Srinivasan V. Iyer, Paea Lependu, Cliff Olson, Nigam H. Shah
"... Background: Peripheral arterial disease (PAD) is a growing problem with few available therapies. Cilostazol is the only FDA-approved medication with a class I indication for intermittent claudication, but carries a black box warning due to concerns for increased cardiovascular mortality. To assess t ..."
Abstract - Cited by 4 (1 self) - Add to MetaCart
subjects from the Stanford clinical data warehouse spanning 18 years using a novel text-mining/statistical analytics pipeline. We identified 232 PAD patients taking Cilostazol and created a control group of 1,160 PAD patients not taking this drug using 1:5 propensity-score matching. Over a mean follow up

Evidence-based treatment and practice: New opportunities to bridge clinical research and practice, enhance the knowledge base, and improve patient care.

by Alan E Kazdin - American Psychologist, , 2008
"... T here is a well-recognized split within clinical psychology between research and practice in professional work, career paths, and training. The split has come into sharper focus with the development and evaluation of empirically supported, or evidence-based, interventions. 1 A central issue is the ..."
Abstract - Cited by 52 (0 self) - Add to MetaCart
T here is a well-recognized split within clinical psychology between research and practice in professional work, career paths, and training. The split has come into sharper focus with the development and evaluation of empirically supported, or evidence-based, interventions. 1 A central issue

TEACHING EVIDENCE BASED PRACTICE

by Randall R. Robey
"... A. Examine teaching evidence-based practice (EBP) from a curricular perspective B. Examine the interaction of students and EBP C. Examine the skills to be taught D. Examine the understandings to be taught E. Examine a variety of learning activities for developing understandings and skills in carryin ..."
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A. Examine teaching evidence-based practice (EBP) from a curricular perspective B. Examine the interaction of students and EBP C. Examine the skills to be taught D. Examine the understandings to be taught E. Examine a variety of learning activities for developing understandings and skills

Learning Drug-Drug Interactions from the Unstructured Text of Electronic Health Records

by Srinivasan V Iyer, Paea Lependu, Rave Harpaz, Anna Bauer-mehren, Nigam H Shah
"... Drug-drug interactions (DDI) account for 30 % of all adverse drug reactions, which are the fourth leading cause of death in the US. Current methods for post marketing surveillance primarily use spontaneous reporting systems for learning DDI signals and validate their signals using the structured por ..."
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spanning 14 adverse events and 1,164 drugs. Our evaluations on this gold standard using over 10 million clinical notes from the Stanford Hospital confirm that learning DDIs from clinical text is feasible (AUROC=81.5%). We conclude that the text in EHRs contain valuable information for learning DDIs and has

EVIDENCE-BASED CLINICAL PRACTICE Evidence-Based Medicine in Primary Care: An Overview

by John P. Geyman
"... Editor's Note: This article is the first in a series of articles that during the next 2 years will sequentially address various evidence-based approaches to the diagnosis and management of common clinical problems in primary care. Future articles will deal with clinical efficacy and effictivene ..."
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Editor's Note: This article is the first in a series of articles that during the next 2 years will sequentially address various evidence-based approaches to the diagnosis and management of common clinical problems in primary care. Future articles will deal with clinical efficacy

Longer-term effects of Head Start

by Eliana Garces , Duncan Thomas , Janet Currie Ucla , Nber - American Economic Review , 2002
"... Abstract Public early intervention programs like Head Start are often justified as investments in children. Yet nothing is known about the long-term effects of Head Start. This paper draws on unique data from the Panel Study of Income Dynamics to provide new evidence on the effects of Head Start on ..."
Abstract - Cited by 131 (5 self) - Add to MetaCart
Abstract Public early intervention programs like Head Start are often justified as investments in children. Yet nothing is known about the long-term effects of Head Start. This paper draws on unique data from the Panel Study of Income Dynamics to provide new evidence on the effects of Head Start

Journal of the American Board of Family Medicine Sixth Annual Practice-based Research Network Theme Issue –They Just Keep Getting Better and Better

by Marjorie A. Bowman, Anne Victoria Neale
"... We have quite a rich issue this month related to practice-based research networks (PBRNs)—reflections on where they have been, where they should go, how they should happen; lessons learned about recruit-ing physicians and patients and new research methods; and several clinical studies from existing ..."
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We have quite a rich issue this month related to practice-based research networks (PBRNs)—reflections on where they have been, where they should go, how they should happen; lessons learned about recruit-ing physicians and patients and new research methods; and several clinical studies from existing

EVIDENCE-BASED CLINICAL PRACTICE Critical Appraisal of the Literature

by William F. Miser
"... A 47-year-old perimenopausal woman, in your office for a well-woman examination, has a newspaper clip-ping given to her by a friend. The clipping reviews a re-cent article published in a well-known national medical journal that warns against the use of hormonal replace-ment therapy (HRT) because of ..."
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methodologically sound that show the overwhelming benefit of HRT 4-6 with no increased risk in breast cancer 7-9 She leaves triumphantly from your office without a prescription, and you feel confused about the overall benefit of HRT. After you make a mental note to read more about HRT, you see your next patient, a

Risk Stratification of ICU Patients Using Topic Models Inferred from Unstructured Progress Notes

by Li-wei Lehman, Mohammed Saeed, William Long, Joon Lee, Roger Mark
"... We propose a novel approach for ICU patient risk stratification by combining the learned “topic ” structure of clinical concepts (represented by UMLS codes) extracted from the unstructured nursing notes with physiologic data (from SAPS-I) for hospital mortality prediction. We used Hierarchical Diric ..."
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We propose a novel approach for ICU patient risk stratification by combining the learned “topic ” structure of clinical concepts (represented by UMLS codes) extracted from the unstructured nursing notes with physiologic data (from SAPS-I) for hospital mortality prediction. We used Hierarchical

Survey of Clinical Knowledge Management and Analysis of Unstructured Text 1. Executive Summary

by William Lau
"... [0001] Today a large portion of biomedical information can be accessed electronically. However, research articles, technical reports, clinical notes, and many other sources of information are stored as free-form text not suited for quantitative analysis. As the amount of data grow everyday, it becom ..."
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[0001] Today a large portion of biomedical information can be accessed electronically. However, research articles, technical reports, clinical notes, and many other sources of information are stored as free-form text not suited for quantitative analysis. As the amount of data grow everyday
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