(sulfonylurea and imidazolinone), which act as potent inhibitors of the enzyme. Recently, we have shown [J. Kim, D.G. Baek, Y.T. Kim, J.D. Choi, M.Y. Yoon, Biochem. J. (2004) 384, 59-68] that the residues in the “mobile loop ” 567-582 on the C-termini are involved in the binding/stabilization of the active

biphenyls, polycyclic aromatic hydrocarbons, perfluorinated

As a group, our project began with a broad question of how the students from East Asia give meanings to their experiences at the Intensive English Institute (IEI), and how their experiences and expectations are shaped by prevailing forces such as neoliberalism, accumulating cosmopolitan capital, and the idea of a global space. We tried to see how East Asian students ’ study abroad decision, experiences, and expectation at the IEI are affected by the exterior forces, and at the same time, how the students navigate these prevailing discourses to create unique subject positions as competent global citizens. In addition, we were also interested in how the IEI is reshaping itself faced with the flux of East Asian students. Shaping our research questions, we drew upon the existing literature on neoliberalism in general(Duggan 2003), and neoliberal subjectivity and global education particularly in East Asia(Anagnost forthcoming, Genda 2005, Lukacs forthcoming, Abelmann et al. forthcoming, Song 2007) and the U.S.(Brooks 2001, Ong 2006). The previous scholarship on the topic shows that the neoliberal trend and changes emphasize individual responsibility, selfdevelopment, privatization, and technical education rather than cultural/moral education. And the literature provides contextual information about our research subjects, particularly after

Although schizophrenia is characterized by gray matter (GM) abnormalities, particularly in the prefrontal and tem-poral cortices, it is unclear whether cerebral cortical GM is abnormal in individuals at ultra-high-risk (UHR) for psychosis. We addressed this issue by studying cortical thickness in this group with magnetic resonance imaging (MRI). We measured cortical thickness of 29 individuals with no family history of psychosis at UHR, 31 patients with schizophrenia, and 29 healthy matched control sub-jects using automated surface-based analysis of structural MRI data. Hemispheric mean and regional cortical thick-ness were significantly different according to the stage of the disease. Significant cortical differences across these 3 groups were found in the distributed area of cerebral cortices. UHR group showed significant cortical thinning in the prefrontal cortex, anterior cingulate cortex, inferior parietal cortex, parahippocampal cortex, and superior temporal gyrus compared with healthy control subjects. Significant cortical thinning in schizophrenia group relative to UHR group was found in all the regions described above in addition with posterior cingulate cortex, insular cortex, and precentral cortex. These changes were more pronounced in the schizophrenia group compared with the control subjects. These findings suggest that UHR is associated with cortical thinning in regions that correspond to the structural abnormalities found in schizophrenia. These structural abnormalities might reflect functional decline at the prodromal stage of schizophrenia, and there may be progressive thinning of GM cortex over time. Key words: MRI/gray matter/cortical thinning/surface-based analysis

Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate

by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bilayer hybrid nanoimprinting method for fabricating embedded silver nanostructure arrays with enhanced photoluminescence

This study evaluates common activity and quality of life in Swedish cohousing units to examine whether Swedish cohousing functions properly or not. A questionnaire survey was fulfilled during the autumn of 2010 in Göteborg Sweden. The subjects of study were 12 of 44 cohousing units in Sweden that included 4 of the +40 cohousing and 8 of the mixed-age cohousing. A total of 242 of 353 distributed questionnaires were collected (68.6%) and analyzed by SPSS statistical program. The findings are as follow: 1) General characteristics of the respondents are that they are mostly healthy, evenly aged from age 50s to 70s and highly educated with significant proportions of academics and civil workers. There are more females than males and more singles than cohabitants. 2) The most frequent and preferred common activity is a common meal followed by a coffee meeting. A common dinner, the ‘hub of living together ’ is held almost every day or at least a few times a week. A common meal is considered one of the most important activities because of practical and social advantages in that residents can save time and cooking costs as well as engage in social contact. Referring to evaluation of frequency and content of common activity, more than a half of the respondents prefer the current situation. 3) All of the variables (except health conditions and education level) affect participation in common activity with statistical significance. 4) Most of the respondents indicate a high level of life satisfaction and are willing to recommend others move to cohousing. They agree that there is more mutual support among residents in cohousing units than in a conventional community. In conclusion, Swedish cohousing units function successfully as they have pursued intentional community ideology and most of the residents are proud of their current living situations.

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C- Terminal carboxyl methylation of a human placental 23 kDa protein catalyzed by membrane-associated methyltransferase has been investigated. The 23 kDa protein substrate methylated was partially purified by DEAE-Sephacel, hydroxyapatite and Sephadex G-100 gel filtration chromatographies. The substrate protein was eluted on Sephadex G-100 gel filtration chromatography as a protein of about 29 kDa. In the absence of Mg2 +, the methylation was stimulated by guanine nucleotides (GTP, GDP and GTP S), but in the presence of Mg2+, only GTP S stimulated the methylation which was similar to the effect on the G25K/rhoGDI complex. AFC, an inhibitor of C-terminal carboxyl methylation, inhibited the methylation of human placental 23 kDa protein. These results sug-gests that the substrate is a small G protein different from the G25K and is methylated on C-terminal isoprenylated cysteine residue. This was also confirmed by vapor phase analysis. The methylated substrate protein was redistributed to membrane after methylation, suggesting that the methylation of this protein is important for the redistribution of the 23 kDa small G protein for its putative role in intracellular signaling.