Datum der Promotion: 14.02.2014 2 Inhaltsverzeichnis Zusammenfassung888888888888888888888888.. 3 Abstrakt (deutsch)88888888.88888888888888... 3 Abstract (english)88888.888888888888888888. 3 Einleitung 88888888888888888888888888... 4 Zielstellung88888888888888888888888888. 5 Methodik88888888888888888888888888..... 5 Ergebnisse88888888888888888888888888.. 10

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IEEE Institut für Medizinische Informatik der Universität zu Lübeck mit Unterstützung durch die Fachgesellschaften:

quantifizieren, insbesondere, wenn einer der Impulse im Ultravioletten liegt, wurde die Gruppengeschwindigkeitsfehlanpassung in elf verschiedenen Lösungsmitteln systematisch vermessen und mittels Sellmeier- und Cauchy-Formeln parametrisiert. Für ein verbessertes Signal-zu-Rausch-Verhätnis sowie zur Vermeidung

-Forschungsrahmenprogramm haben wir in Europa eine gute Ausgangslage geschaffen, diesen Wettbewerb zu bestehen. Mit einer Laufzeit von sieben Jahren und einem Gesamtbudget von rund 54 Milliarden € ist es das bislang größte Rahmenprogramm und übertrifft die Fördermittel

Optimization of red fluorescent marker proteins guided by evaluation of structurefunction relations

oxidation of methane by marine consortia enriched in vitro 32 III.2 Carbon and sulfur back flux during anaerobic microbial oxidation of methane and coupled sulfate reduction 44 III.3 Microbiological investigation of methane- and hydrocarbon-discharging mud volcanoes in the Carpathian Mountains

der Forschungs- und Innovationspolitik A.F.J. van Raan: The use of bibliometric analysis in research performance assessment and monitoring of interdisciplinary scientific developments W. Grossenbacher-Mansuy, S. Bellucci, S. Kanaan: Evaluation des Zentrums für Technologiefolgen-Abschätzung TA

RNA folding is viewed here as a map assigning secondary structures to sequences and hence as an example of general genotype to phenotype mappings. RNA secondary structures can be represented as planar vertex-labeled graphs or as trees. We construct recursion formulae enumerating various sub-classes of these graphs as well as certain structural elements and derive first order asymptotics for their frequencies. The number of secondary structures at fixed chain length turns out to be much lower than the number of sequences. A package of e#cient algorithms for the prediction of RNA secondary structures and their comparison is introduced. It is complemented by a novel heuristic "inverse folding" algorithm that searches for sequences which fold into a given secondary structure. The mapping from sequences to secondary structures is then studied in a series of computer experiments. Statistics of secondary structure elements of folded random sequences are compiled and compared to random structures. In addition, we derive a lower bound on the number of folded structures from the mean number of base pairs. The frequency distribution of structures is found to be highly nonuniform, with few common structures and many rare ones, to a good approximation the distribution can be described by a generalized form of Zipf's law. Using the inverse folding algorithm sequences folding into some given structure are shown to be randomly distributed in sequence space. As a consequence of the many to one mapping, common structures can be found within a relatively small distance (less than 20% of the diameter of sequence space) from any random sequence. Furthermore, the high number of neutral mutations leads to extended networks of neighboring sequences sharing the same structure. Neutral nets belo...

Eigenschaften an Grenzflächen zusammen. Beiden ist gemeinsam, daß angeregt