have been devised to survey gene functions en masse either computationally (Marcotte et al., 1999) or experimentally; among these, highly parallel assays of

Abstract not found

El Salvador, Guatemala is a, study in black and white. On the left is a collection of extreme Marxist-Leninist groups led by what one diplomat calls “a pretty faceless bunch of people.’ ’ On the right is an entrenched elite that has dominated Central America’s most populous country since a CIA-backed coup deposed the reformist government of Col. Jacobo Arbenz Guzmán in 1954. Moderates of the political center. embattled but alive in E1 Salvador, have virtually disappeared in Guatemala-joining more than 30.000 victims of terror over the last tifteen vears. “The situation in Guatemala is much more serious than in EI Salvador, ” declares one Latin American diplomat. “The oligarchy is that much more reactionary. and the choices are far fewer. “ ‘Zero’: The Guatemalan oligarchs hated Jimmy Carter for cutting off U.S. military aid in 1977 to protest human-rights abuses-and the right-wingers hired marimba bands and set off firecrackers on the night Ronald Reagan was elected. They considered Reagan an ideological kinsman and believed they had a special

polymorphism explains differences in binding affinity of the PET radioligand PBR28

Purpose Evaluation of translocator protein (TSPO) overex-pression is considered an attractive research tool for monitor-ing neuroinflammation in several neurological and psychiatric disorders. [11C]PK11195 PET imaging has been widely used for this purpose. However, it has a low sensitivity and a

Whole-body PET/CT was used to characterize the radiation dosimetry of 11C-DPA-713, a specific PET ligand for the assess-ment of translocator protein. Methods: Six healthy control sub-jects, 3 men and 3 women, underwent whole-body dynamic PET scans after bolus injection of 11C-DPA-713. Subjects were

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molecular imaging (MI) agents capable of monitoring changes in TSPO expression occurring in vivo and in response to various neuropathologies. Here we tested the pharmacological characteristics and TSPO-monitoring potential of two novel MI agents: NIR-conPK and NIR-6T. NIR-conPK is an analogue of PK 11195

The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa trans-locator protein (TSPO), is thought to be essential for cholesterol transport and steroidogenesis, and thus life. TSPO has been proposed as a biomarker of neuroinflammation and a new drug target in neurological

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