Algorithms for comparing protein structure are frequently used for function annotation. By searching for subtle similarities among very different proteins, these algorithms can identify remote homologs with similar biological functions. In contrast, few comparison algorithms focus on specificity

Proteins are large biomolecules comprising of α – L amino acids connected by peptide bonds. They fold into a three dimensional structure to become functionally significant. Most of the information related to protein folding is embedded within the primary peptide sequence itself. With the advent

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) are known for interaction with DNA. Identifying such a motif in a novel protein can lend support to its classification as a DNA-binding protein • Structural Neighborhood A simple representation of residue environment is to count the other amino acids inside a ball centered on the residue of interest

is a polymorphic human enzyme with malate

CLYBL is a polymorphic human enzyme with malate synthase and -methylmalate synthase activity

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gene nomenclatures, ontologies and a universal numbering of the IG/TR V and C domains, thus giving a common access to standardized data from genome, proteome, genetics, two-dimensional, and three-dimensional structures (146). The accuracy and the consistency of the IMGT® data are based on IMGT

I declare that this thesis is my own account of my research and contains as its main content work which has not previously been submitted for a degree at any tertiary education institution.

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