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Results 1 - 10
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315
Discovering Local Structure in Gene Expression Data: The Order-Preserving Submatrix Problem
, 2002
"... This paper concerns the discovery of patterns in gene expression matrices, in which each element gives the expression level of a given gene in a given experiment. Most existing methods for pattern discovery in such matrices are based on clustering genes by comparing their expression levels in all ex ..."
Abstract
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Cited by 187 (1 self)
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in the progress of a disease or in a cellular process and the expression levels of all genes in G vary across the stages in the same way. We de � ne a probabilistic model in which an OPSM is hidden within an otherwise random matrix. Guided by this model, we develop an ef � cient algorithm for � nding the hidden
Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain
- PLoS ONE
, 2008
"... Imprinted genes display differential allelic expression in a manner that depends on the sex of the transmitting parent. The degree of imprinting is often tissue-specific and/or developmental stage-specific, and may be altered in some diseases including cancer. Here we applied Illumina/Solexa sequenc ..."
Abstract
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Cited by 46 (2 self)
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Imprinted genes display differential allelic expression in a manner that depends on the sex of the transmitting parent. The degree of imprinting is often tissue-specific and/or developmental stage-specific, and may be altered in some diseases including cancer. Here we applied Illumina
The murine testicular transcriptome: characterizing gene expression in the testis during the progression of spermatogenesis
- FIGURES, LEGENDS & TABLES
, 2004
"... One of the most promising applications of microarrays is the study of changes in gene expression associated with the growth and development of mammalian tissues. The testis provides an excellent model to determine the ability of microarrays to effectively characterize the changes in gene expression ..."
Abstract
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Cited by 25 (3 self)
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with cell-specific expression profiles. Analysis of cell-specific expression patterns produced unique and characteristic groups of transcripts that provide greater insight into the activities, biological and chronological, of testicular cell types during the progression of spermatogenesis. Further analysis
Dissection of symbiosis and organ development by integrated transcriptome analysis of lotus japonicus mutant and wild-type plants. PLoS One
, 2009
"... Genetic analyses of plant symbiotic mutants has led to the identification of key genes involved in Rhizobium-legume communication as well as in development and function of nitrogen fixing root nodules. However, the impact of these genes in coordinating the transcriptional programs of nodule developm ..."
Abstract
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Cited by 13 (0 self)
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development has only been studied in limited and isolated studies. Here, we present an integrated genome-wide analysis of transcriptome landscapes in Lotus japonicus wild-type and symbiotic mutant plants. Encompassing five different organs, five stages of the sequentially developed determinate Lotus root
RESEARCH ARTICLE Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation
"... Integration of multiple profiling data and construction of functional gene networks may pro-vide additional insights into the molecular mechanisms of complex diseases. Osteoporosis is a worldwide public health problem, but the complex gene-gene interactions, post-tran-scriptional modifications and r ..."
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Integration of multiple profiling data and construction of functional gene networks may pro-vide additional insights into the molecular mechanisms of complex diseases. Osteoporosis is a worldwide public health problem, but the complex gene-gene interactions, post-tran-scriptional modifications
Materials for an exploratory theory of the network society.
- The British Journal of Sociology
, 2000
"... ABSTRACT This article aims at proposing some elements for a grounded theor y of the network society. The network society is the social structure characteristic of the Information Age, as tentatively identi ed by empirical, cross-cultural investigation. It permeates most societies in the world, in v ..."
Abstract
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Cited by 122 (0 self)
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sociological theory able to grasp emerging forms of social organization and con ict. This theory is still in its explorator y stage, and should remain, like all relevant theories, as a work in progress open to recti cation by empirical research. Because I am trying to distill theory from observation, I
PhenoNet: Identification of key networks associated with disease
"... Motivation: At the core of transcriptome analyses of cancer is a challenge to detect molecular differences affiliated with disease phenotypes. This approach has led to remarkable progress in identi-fying molecular signatures and in stratifying patients into clinical groups. Yet, despite this progres ..."
Abstract
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Motivation: At the core of transcriptome analyses of cancer is a challenge to detect molecular differences affiliated with disease phenotypes. This approach has led to remarkable progress in identi-fying molecular signatures and in stratifying patients into clinical groups. Yet, despite
Integrating the Alzheimer's disease proteome and transcriptome: a comprehensive network model of a complex disease
- OMICS
, 2012
"... Network models combined with gene expression studies have become useful tools for studying complex dis-eases like Alzheimer’s disease. We constructed a ‘‘Core’ ’ Alzheimer’s disease protein interaction network by human curation of the primary literature. The Core network consisted of 775 nodes and 2 ..."
Abstract
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Cited by 5 (0 self)
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,945 nodes and 26,064 interactions. We then mapped existing gene expression studies to the Core network. This combined data model identified the MAPK/ ERK pathway and clathrin-mediated receptor endocytosis as key pathways in Alzheimer’s disease. Important proteins in the MAPK/ERK pathway that interacted
Molecular & Biochemical Parasitology 143 (2005) 67–79 The Plasmodium falciparum sexual development transcriptome: A microarray analysis using ontology-based pattern identification
, 2005
"... The sexual stages of malarial parasites are essential for the mosquito transmission of the disease and therefore are the focus of transmissionblocking drug and vaccine development. In order to better understand genes important to the sexual development process, the transcriptomes of high-purity stag ..."
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-purity stage I–V Plasmodium falciparum gametocytes were comprehensively profiled using a full-genome high-density oligonucleotide microarray. The interpretation of this transcriptional data was aided by applying a novel knowledge-based data-mining algorithm termed ontology-based pattern identification (OPI
Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer’s Disease
, 2014
"... Accumulating evidence links numerous abnormalities in cerebral metabolism with the progression of Alzheimer’s disease (AD), beginning in its early stages. Here, we integrate transcriptomic data from AD patients with a genome-scale computational human metabolic model to characterize the altered metab ..."
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Accumulating evidence links numerous abnormalities in cerebral metabolism with the progression of Alzheimer’s disease (AD), beginning in its early stages. Here, we integrate transcriptomic data from AD patients with a genome-scale computational human metabolic model to characterize the altered
Results 1 - 10
of
315
