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Molecular Immunology 40 (2004) 647–660 Review IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics

by Marie-paule Lefranc A B , 2003
"... The international ImMunoGeneTics information system ® (IMGT; ..."
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The international ImMunoGeneTics information system ® (IMGT;

and Web Resources for Immunoinformatics

by Marie-paule Lefranc
"... Abstract. IMGT®, the international ImMunoGeneTics information system®, was created in 1989 as a high-quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complexes (MHC) of human and other vertebrates, and related proteins of the ..."
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of the immune system (RPI) which belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF). IMGT ® is the international reference in immuno-genetics and immunoinformatics. IMGT ® combines sequence databases (IMGT/LIGM-DB, IMGT/PRIMER-DB, IMGT/PROTEIN-DB, IMGT/MHC-DB), a genome database

2IMGT®, the International ImmunoGeneTics Information System ® for Immunoinformatics Methods for Querying IMGT ® Databases, Tools, and Web Resources in the Context of Immunoinformatics

by Marie-paule Lefranc
"... Montpellier II and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. IMGT ® is recognized as the international reference in immunogenetics and immunoinformatics. IMGT ® is a high quality integrated knowledge resource, specialized in (i) the immun ..."
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Montpellier II and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. IMGT ® is recognized as the international reference in immunogenetics and immunoinformatics. IMGT ® is a high quality integrated knowledge resource, specialized in (i

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by Xavier Brochet, Patrice Duroux, François Ehrenmann, Yan Wu, Kevin Bleakley, Gérard Biau, Véronique Giudicelli, Marie-paule Lefranc , 2007
"... Montpellier, France) is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system (RPI) [1]. The IMGT information system consists of databas ..."
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of databases, interactive tools and web resources. The accuracy and the consistency of the IMGT components are based on IMGT-ONTOLOGY [2], the first ontology in immunogenetics and immunoinformatics. IMGT-ONTOLOGY provides a semantic specification and definition of terms and rules which ensure the coherence

IMGT/LIGMotif: A tool to annotate V-, D- and J-GENE of

by France Juillet, Brun C, Didier G. (eds, Jérôme Lane, Marie-paule Lefranc, Patrice Duroux
"... Abstract: The aim of this work is to investigate the bioinformatic problem of annotating immunoglobulin (IG) and T cell receptor (TR) loci in genomic DNA of vertebrates owing to the unusual structure of variable, diversity and joining types of genes symbolised by V-, D- and J-GENE, respectively. Ind ..."
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®. At present time the software can predict these IG and TR genes for human and mouse. The processing of the annotation is based on the DESCRIPTION concept established in IMGT-ONTOLOGY, the first ontology in the domain of immunogenetics and immunoinformatics. The implemented algorithm combines a similarity

IOS Press T Cell Receptor/Peptide/MHC Molecular Characterization and Standardized pMHC

by Contact Sites In Imgt/dstructure-db, Quentin Kaas, Marie-paule Lefranc , 2005
"... ABSTRACT: One of the key elements in the adaptive immune response is the presentation of peptides by the major histocom-patibility complex (MHC) to the T cell receptors (TR) at the surface of T cells. The characterization of the TR/peptide/MHC trimolecular complexes (TR/pMHC) is crucial to the field ..."
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.cines.fr), has developed IMGT-ONTOLOGY, the first ontology in immunogenetics and immunoinformatics. In IMGT/3Dstructure-DB, the IMGT three-dimensional structure database, TR/pMHC molecular characterization and pMHC contact analysis are made according to the IMGT Scientific chart rules, based on the IMGT-ONTOLOGY

IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or

by T Cell Receptors, Quentin Kaas, Marie-paule Lefranc , 2009
"... IMGT/3Dstructure-DB is the three-dimensional (3D) structure database of IMGT, the international ImMunoGenetics information system that is acknowledged as the global reference in immunogenetics and immunoinformatics. IMGT/ 3Dstructure-DB contains 3D structures of immunoglobulins (IG) or antibodies, ..."
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IMGT/3Dstructure-DB is the three-dimensional (3D) structure database of IMGT, the international ImMunoGenetics information system that is acknowledged as the global reference in immunogenetics and immunoinformatics. IMGT/ 3Dstructure-DB contains 3D structures of immunoglobulins (IG) or antibodies

RESEARCH ARTICLE IMGT/HighV-QUEST Statistical Significance of IMGT Clonotype (AA) Diversity per Gene for Standardized Comparisons of Next Generation Sequencing Immunoprofiles of

by T Cell Receptors, Safa Aouinti, Dhafer Malouche, Véronique Giudicelli, Sofia Kossida, Paule Lefranc
"... The adaptive immune responses of humans and of other jawed vertebrate species (gnasthostomata) are characterized by the B and T cells and their specific antigen recep-tors, the immunoglobulins (IG) or antibodies and the T cell receptors (TR) (up to 2.1012 dif-ferent IG and TR per individual). IMGT, ..."
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, the international ImMunoGeneTics information system (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc (Montpellier Uni-versity and CNRS) to manage the huge and complex diversity of these antigen receptors. IMGT built on IMGT-ONTOLOGY concepts of identification (keywords), description (labels

The past, present, and future of immune repertoire biology—the rise of next-generation repertoire analysis. Front Immunol 4

by Adrien Six , Maria Encarnita Mariotti-Ferrandiz , Wahiba Chaara , Susana Magadan , Hang-Phuong Pham , Marie-Paule Lefranc , Thierry Mora , Véronique Thomas-Vaslin , Aleksandra M Walczak , Pierre Boudinot , Koji Yasutomo , 2013
"... T and B cell repertoires are collections of lymphocytes, each characterized by its antigenspecific receptor. We review here classical technologies and analysis strategies developed to assess immunoglobulin (IG) and T cell receptor (TR) repertoire diversity, and describe recent advances in the field ..."
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gene nomenclatures, ontologies and a universal numbering of the IG/TR V and C domains, thus giving a common access to standardized data from genome, proteome, genetics, two-dimensional, and three-dimensional structures (146). The accuracy and the consistency of the IMGT® data are based on IMGT-ONTOLOGY
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