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Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus

by Craig Hammond, Ari Helenius - J. Cell , 1994
"... Abstract. Proteins synthesized in the ER are generally transported to the Golgi complex and beyond only when they have reached a fully folded and assembled conformation. To analyze how the selective retention of misfolded proteins works, we monitored the longterm fate of a membrane glycoprotein with ..."
Abstract - Cited by 159 (6 self) - Add to MetaCart
Abstract. Proteins synthesized in the ER are generally transported to the Golgi complex and beyond only when they have reached a fully folded and assembled conformation. To analyze how the selective retention of misfolded proteins works, we monitored the longterm fate of a membrane glycoprotein

The clathrin endocytic pathway in viral infection

by Louis Detulleo, Tomas Kirchhausen - EMBO J , 1998
"... How important is the clathrin-dependent endocytic pathway for entry of viruses into host cells? While it is widely accepted that Semliki Forest virus (SFV), an enveloped virus, requires this pathway there are conflicting data concerning the closely related Sindbis virus, as well as varying results w ..."
Abstract - Cited by 77 (1 self) - Add to MetaCart
How important is the clathrin-dependent endocytic pathway for entry of viruses into host cells? While it is widely accepted that Semliki Forest virus (SFV), an enveloped virus, requires this pathway there are conflicting data concerning the closely related Sindbis virus, as well as varying results

• VIRAL HEPATITIS •

by Chuan-long Zhu, Wei-ming Yan, Fan Zhu, Yong-fen Zhu, Dong Xi, De-ying Tian, Xiao-ping Luo, Qin Ning, Co-fi Rst-authors Chuan-long Zhu, Wei-ming Yan
"... AIM: To evaluate the expression of f ibr inogen-like protein 2 (fgl2) and its correlation with disease progression in both mice and patients with severe viral hepatitis. METHODS: Ba lb/cJ or A/J mice were in fected intraperitoneally (ip) with 100 PFU of murine hepatitis virus type 3 (MHV-3), liver a ..."
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AIM: To evaluate the expression of f ibr inogen-like protein 2 (fgl2) and its correlation with disease progression in both mice and patients with severe viral hepatitis. METHODS: Ba lb/cJ or A/J mice were in fected intraperitoneally (ip) with 100 PFU of murine hepatitis virus type 3 (MHV-3), liver

Viral information

by Forest Rohwer, Katie Barott, F. Rohwer, K. Barott, Biol Philos , 2012
"... The Author(s) 2012. This article is published with open access at Springerlink.com Abstract Viruses are major drivers of global biogeochemistry and the etiological agents of many diseases. They are also the winners in the game of life: there are more viruses on the planet than cellular organisms an ..."
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in nature). Finally, we show how viral information can be tested, and illustrate how this novel view can explain existing ecological and evolutionary theories from more fundamental principles.

How to go Viral: Cheaply and Quickly

by F. Cicalese, G. Cordasco, L. Gargano, J. Peters, U. Vaccaro, et al. , 2014
"... ..."
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Abstract not found

Virality 1 Social Transmission and Viral Culture

by Jonah Berger, Katherine L. Milkman, Lauren Mcdevitt, Areeb Pirani, Jason Pollack
"... conference, and the University of Chicago for helpful comments on a prior version of the manuscript. The Wharton Interactive Media Initiative helped fund this research. Virality 2 People often share news, opinions, and information, and social transmission shapes both individual behavior and collecti ..."
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. The magnitudes of these relationships are considerable. These results underscore the importance of considering how individual-level psychological processes shape collective outcomes such as the transmission and prominence of culture. KEYWORDS: Social Transmission, Word-of-Mouth, Social EpidemicsVirality 3

Viral chemokine-binding proteins

by Bruce T. Seet, Grant Mcfadden - J. Leukoc , 2002
"... Abstract: The chemokines are a large family of small signaling proteins that bind to G-protein-coupled receptors (GPCRs) on target cells and mediate the directional migration of immune cells into sites of infection or inflammation. The large DNA viruses, particularly the poxviruses and herpesviruses ..."
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by poxviruses and herpesviruses. A better understanding of how viral CKBPs function to manipulate the immune response may provide further clues as to how to develop specific therapeutic agents to abrogate chemokine-mediated disease conditions. J. Leukoc. Biol. 72:

Evolving viral marketing strategies

by Forrest Stonedahl, William R, Uri Wilensky - In GECCO ’10: Proceedings of the 12th annual conference on genetic and evolutionary computation , 2010
"... One method of viral marketing involves seeding certain consumers within a population to encourage faster adoption of the product throughout the entire population. However, determining how many and which consumers within a particular social network should be seeded to maximize adoption is challenging ..."
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One method of viral marketing involves seeding certain consumers within a population to encourage faster adoption of the product throughout the entire population. However, determining how many and which consumers within a particular social network should be seeded to maximize adoption

A Measurement-driven Analysis of Information Propagation in the Flickr Social Network

by Meeyoung Cha, Alan Mislove, Krishna P. Gummadi
"... Online social networking sites like MySpace, Facebook, and Flickr have become a popular way to share and disseminate content. Their massive popularity has led to viral marketing techniques that attempt to spread content, products, and ideas on these sites. However, there is little data publicly avai ..."
Abstract - Cited by 151 (3 self) - Add to MetaCart
available on viral propagation in the real world and few studies have characterized how information spreads over current online social networks. In this paper, we collect and analyze large-scale traces of information dissemination in the Flickr social network. Our analysis, based on crawls of the favorite

ABSTRACT The Dynamics of Viral Marketing ∗

by Jure Leskovec
"... We present an analysis of a person-to-person recommendation network, consisting of 4 million people who made 16 million recommendations on half a million products. We observe the propagation of recommendations and the cascade sizes, which we explain by a simple stochastic model. We then establish ho ..."
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how the recommendation network grows over time and how effective it is from the viewpoint of the sender and receiver of the recommendations. While on average recommendations are not very effective at inducing purchases and do not spread very far, we present a model that successfully identifies product
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