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965
PLATFORMS
"... Abstract: The work described in this paper is focused on the attainment of a product that: a) is able to manage a communication network according to ISO ant ITU-T standards (Telecommunication Management Network, TMN, model); b) automatically locates network faults based on a set of rules embedded in ..."
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Abstract: The work described in this paper is focused on the attainment of a product that: a) is able to manage a communication network according to ISO ant ITU-T standards (Telecommunication Management Network, TMN, model); b) automatically locates network faults based on a set of rules embedded
Entropia: Architecture and Performance of an Enterprise Desktop Grid System
, 2003
"... The exploitation of idle cycles on pervasive desktop PC systems offers the opportunity to increase the available computing power by orders of magnitude (10x - 1000x). However, for desktop PC distributed computing to be widely accepted within the enterprise, the systems must achieve high levels of ef ..."
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Cited by 164 (10 self)
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for the Entropia System includes molecular docking, sequence analysis, chemical structure modeling, and risk management. The applications come from a diverse set of domains including virtual screening for drug discovery, genomics for drug targeting, material property prediction, and portfolio management. In all
Data Management for High-Throughput Genomics
"... Today's sequencing technology allows sequencing an individual genome within a few weeks for a fraction of the costs of the original Human Genome project. Genomics labs are faced with dozens of TB of data per week that have to be automatically processed and made available to scientists for furth ..."
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Cited by 6 (1 self)
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for further analysis. This paper explores the potential and the limitations of using relational database systems as the data processing platform for high-throughput genomics. In particular, we are interested in the storage management for high-throughput sequence data and in leveraging SQL and user
A DNA Microarray LIMS System for Integral Genomic Analysis of Multi-Platform Microarrays
, 2007
"... The analysis of DNA microarray data is a rapidly evolving area of bioinformatics, and various types of microarray are emerging as some of the most exciting technologies for use in biological and clinical research. In recent years, microarray technology has been utilized in various applications such ..."
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-validation. There are a number of separate laboratory information management systems (LIMS) that individually address some of the needs for each platform. However, to our knowledge there are no unified LIMS systems capable of organizing all of the information regarding multi-platform microarray experiments, while
Object-oriented Knowledge Bases for the Analysis of Prokaryotic and Eukaryotic Genomes
, 1993
"... example, the expressivity of E. coli genes can be inferred from complex computations applied to sequences. A query to retrieve highly expressed genes needs that the system "knows" the method to estimate expressivity. Object models are particularly adapted to manage and to integrate these t ..."
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example, the expressivity of E. coli genes can be inferred from complex computations applied to sequences. A query to retrieve highly expressed genes needs that the system "knows" the method to estimate expressivity. Object models are particularly adapted to manage and to integrate
Ontology Middleware: Platform for Real-World Knowledge Management
"... Abstract. An ontology middleware system is defined, presented, and discussed in this paper. It includes number of features critical for the implementation of real-world knowledge management application: versioning, fine-grained access control, and meta-information. Important part of the research pre ..."
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presented is the definition of proper models for support for each of these aspects. A security model with three levels of complexity is designed so to support proper management of the compromise between complexity and efficiency. The system presented is under development as a part of the On-To-Knowledge
B.: Graph database systems for genomics
- IEEE Eng.Medicine Biol
, 1995
"... Genome databases have specific requirements which limit the usefulness of some da-tabase management systems. By using more appropriate database technology, a data-base system can be developed for genome data. We have developed a data representation based on graph theory which captures the highly int ..."
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Cited by 4 (0 self)
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interconnected structure of genome data. Graphs are a language which can be tailored for describing genomic in-formation, and we develop a data model based on graphs which serves as the founda-tion of a graph database management system.
The integrated microbial genomes (IMG) system in 2007: data content and analysis tool extensions
- Nucleic Acids Res
, 2008
"... ABSTRACT The Integrated Microbial Genomes (IMG) system is a data management, analysis and annotation platform for all publicly available genomes. IMG contains both draft and complete JGI microbial genomes integrated with all other publicly available genomes from all three domains of life, together ..."
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Cited by 62 (16 self)
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ABSTRACT The Integrated Microbial Genomes (IMG) system is a data management, analysis and annotation platform for all publicly available genomes. IMG contains both draft and complete JGI microbial genomes integrated with all other publicly available genomes from all three domains of life, together
Genomics and bioinformatics resources for crop improvement
- Plant Cell Physiol. 2010
"... Recent remarkable innovations in platforms for omics-based research and application development provide crucial resources to promote research in model and applied plant species. A combinatorial approach using multiple omics platforms and integration of their outcomes is now an effective strategy for ..."
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Cited by 19 (2 self)
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for clarifying molecular systems integral to improving plant productivity. Furthermore, promotion of comparative genomics among model and applied plants allows us to grasp the biological properties of each species and to accelerate gene discovery and functional analyses of genes. Bioinformatics platforms
SOFTWARE Open Access Genomics Portals: integrative web-platform for mining genomics data
"... Background: A large amount of experimental data generated by modern high-throughput technologies is available through various public repositories. Our knowledge about molecular interaction networks, functional biological pathways and transcriptional regulatory modules is rapidly expanding, and is be ..."
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, and is being organized in lists of functionally related genes. Jointly, these two sources of information hold a tremendous potential for gaining new insights into functioning of living systems. Results: Genomics Portals platform integrates access to an extensive knowledge base and a large database of human
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