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Results 1 - 10
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218
GENETIC CLUSTERING ON THE HIPPOCAMPAL SURFACE FOR GENOME-WIDE ASSOCIATION STUDIES
"... Imaging genetics aims to discover how variants in the human genome influence brain measures derived from images. Genome-wide association scans (GWAS) can screen the genome for common differences in our DNA that relate to brain measures. In small samples, GWAS has low power as individual gene effects ..."
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Imaging genetics aims to discover how variants in the human genome influence brain measures derived from images. Genome-wide association scans (GWAS) can screen the genome for common differences in our DNA that relate to brain measures. In small samples, GWAS has low power as individual gene
Mixed linear model approach adapted for genome-wide association studies.
- Nat Genet.
, 2010
"... 5 5 t e c h n i c a l r e p o r t s Mixed linear model (MLM) methods have proven useful in controlling for population structure and relatedness within genome-wide association studies. However, MLM-based methods can be computationally challenging for large datasets. We report a compression approach, ..."
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Cited by 35 (6 self)
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in controlling for substructure in genetic association datasets for a range of species and genetic architectures. We have made these methods available within an implementation of the software program TASSEL. Although genome-wide association studies (GWAS) have the potential to pinpoint genetic polymorphisms
Rotimi C: A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet 2009
"... The evidence for the existence of genetic susceptibility variants for the common form of hypertension (‘‘essential hypertension’’) remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a ..."
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Cited by 40 (6 self)
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The evidence for the existence of genetic susceptibility variants for the common form of hypertension (‘‘essential hypertension’’) remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a
UPC++ for Bioinformatics: A Case Study Using Genome-Wide Association Studies
- In Proc. 15th IEEE Intl. Conf. on Cluster Comp. (Cluster’14
, 2014
"... Abstract—Modern genotyping technologies are able to obtain up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important but time-consuming operation since statis ..."
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Cited by 4 (2 self)
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Abstract—Modern genotyping technologies are able to obtain up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important but time-consuming operation since
A Genome-Wide Association Study on Chronic HBV Infection and Its Clinical Progression in Male Han- Taiwanese
"... It is common to observe the clustering of chronic hepatitis B surface antigen (HBsAg) carriers in families. Intra-familial transmission of hepatitis B virus (HBV) could be the reason for the familial clustering of HBsAg carriers. Additionally, genetic and gender factors have been reported to be invo ..."
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to be involved. We conducted a three-stage genome-wide association study to identify genetic factors associated with chronic HBV susceptibility. A total of 1,065 male controls and 1,623 male HBsAg carriers were included. The whole-genome genotyping was done on Illumina HumanHap550 beadchips in 304 healthy
Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels
- Nature Genetics
, 2013
"... Association mapping can quickly and efficiently dissect complex agronomic traits. Rapeseed is one of the most economically important polyploid oil crops, although its genome sequence is not yet published. In this study, a recently developed 60K Brassica Infiniumw SNP array was used to analyse an ass ..."
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Cited by 25 (2 self)
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Association mapping can quickly and efficiently dissect complex agronomic traits. Rapeseed is one of the most economically important polyploid oil crops, although its genome sequence is not yet published. In this study, a recently developed 60K Brassica Infiniumw SNP array was used to analyse
Genomic Regions Identified by Overlapping Clusters of Nominally-Positive SNPs from Genome-Wide Studies of Alcohol and Illegal Substance Dependence
"... Declaring ‘‘replication’ ’ from results of genome wide association (GWA) studies is straightforward when major gene effects provide genome-wide significance for association of the same allele of the same SNP in each of multiple independent samples. However, such unambiguous replication is unlikely w ..."
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Cited by 5 (0 self)
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Declaring ‘‘replication’ ’ from results of genome wide association (GWA) studies is straightforward when major gene effects provide genome-wide significance for association of the same allele of the same SNP in each of multiple independent samples. However, such unambiguous replication is unlikely
Genome-Wide Maps of Circulating miRNA Biomarkers for
"... Inflammatory Bowel Disease – comprised of Crohn’s Disease and Ulcerative Colitis (UC)- is a complex, multi-factorial inflammatory disorder of the gastrointestinal tract. In this study we have explored the utility of naturally occurring circulating miRNAs as potential blood-based biomarkers for non-i ..."
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. Interestingly, comparison of the miRNA biomarker panel and genetic loci implicated in IBD through genome-wide
SEARCHING GENOME-WIDE DISEASE ASSOCIATION THROUGH SNP DATA by
"... Taking the advantage of the high-throughput Single Nucleotide Polymorphism (SNP) genotyping technology, Genome-Wide Association Studies (GWASs) are regarded holding promise for unravelling complex relationships between genotype and phenotype. GWASs aim to identify genetic variants associated with di ..."
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Taking the advantage of the high-throughput Single Nucleotide Polymorphism (SNP) genotyping technology, Genome-Wide Association Studies (GWASs) are regarded holding promise for unravelling complex relationships between genotype and phenotype. GWASs aim to identify genetic variants associated
A Genome-Wide Association Study of the Maize Hypersensitive Defense Response Identifies Genes That Cluster in Related Pathways
"... Much remains unknown of molecular events controlling the plant hypersensitive defense response (HR), a rapid localized cell death that limits pathogen spread and is mediated by resistance (R-) genes. Genetic control of the HR is hard to quantify due to its microscopic and rapid nature. Natural modif ..."
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(QTL) using a linkage map based on more than 7000 single nucleotide polymorphisms (SNPs). Genome-wide association (GWA) analysis of 26.5 million SNPs was conducted after adjusting for background QTL. GWA identified associated SNPs that colocalized with 44 candidate genes. Thirty-six of these genes
Results 1 - 10
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218
