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GENETIC CLUSTERING ON THE HIPPOCAMPAL SURFACE FOR GENOME-WIDE ASSOCIATION STUDIES

by Derrek P. Hibar, Sarah E. Medl, Jason L. Stein, Sungeun Kim, Li Shen, Andrew J. Saykin, Greig I. De Zubicaray, Katie L. Mcmahon, Grant W. Montgomery, Nicholas G. Martin, Margaret J. Wright, Srdjan Djurovic, Ingrid Agartz, Ole A. Andreassen, Paul M. Thompson
"... Imaging genetics aims to discover how variants in the human genome influence brain measures derived from images. Genome-wide association scans (GWAS) can screen the genome for common differences in our DNA that relate to brain measures. In small samples, GWAS has low power as individual gene effects ..."
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Imaging genetics aims to discover how variants in the human genome influence brain measures derived from images. Genome-wide association scans (GWAS) can screen the genome for common differences in our DNA that relate to brain measures. In small samples, GWAS has low power as individual gene

Mixed linear model approach adapted for genome-wide association studies.

by Zhiwu Zhang , Elhan Ersoz , Chao-Qiang Lai , Rory J Todhunter , Hemant K Tiwari , Michael A Gore , Peter J Bradbury , Jianming Yu , Donna K Arnett , Jose M Ordovas , Edward S Buckler - Nat Genet. , 2010
"... 5 5 t e c h n i c a l r e p o r t s Mixed linear model (MLM) methods have proven useful in controlling for population structure and relatedness within genome-wide association studies. However, MLM-based methods can be computationally challenging for large datasets. We report a compression approach, ..."
Abstract - Cited by 35 (6 self) - Add to MetaCart
in controlling for substructure in genetic association datasets for a range of species and genetic architectures. We have made these methods available within an implementation of the software program TASSEL. Although genome-wide association studies (GWAS) have the potential to pinpoint genetic polymorphisms

Rotimi C: A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet 2009

by Adebowale Adeyemo, Norman Gerry, Guanjie Chen, Alan Herbert, Ayo Doumatey, Hanxia Huang, Jie Zhou, Kerrie Lashley, Yuanxiu Chen, Michael Christman, Charles Rotimi
"... The evidence for the existence of genetic susceptibility variants for the common form of hypertension (‘‘essential hypertension’’) remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a ..."
Abstract - Cited by 40 (6 self) - Add to MetaCart
The evidence for the existence of genetic susceptibility variants for the common form of hypertension (‘‘essential hypertension’’) remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a

UPC++ for Bioinformatics: A Case Study Using Genome-Wide Association Studies

by Jan C. Kässens, Lars Wienbr, Bertil Schmidt - In Proc. 15th IEEE Intl. Conf. on Cluster Comp. (Cluster’14 , 2014
"... Abstract—Modern genotyping technologies are able to obtain up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important but time-consuming operation since statis ..."
Abstract - Cited by 4 (2 self) - Add to MetaCart
Abstract—Modern genotyping technologies are able to obtain up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important but time-consuming operation since

A Genome-Wide Association Study on Chronic HBV Infection and Its Clinical Progression in Male Han- Taiwanese

by unknown authors
"... It is common to observe the clustering of chronic hepatitis B surface antigen (HBsAg) carriers in families. Intra-familial transmission of hepatitis B virus (HBV) could be the reason for the familial clustering of HBsAg carriers. Additionally, genetic and gender factors have been reported to be invo ..."
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to be involved. We conducted a three-stage genome-wide association study to identify genetic factors associated with chronic HBV susceptibility. A total of 1,065 male controls and 1,623 male HBsAg carriers were included. The whole-genome genotyping was done on Illumina HumanHap550 beadchips in 304 healthy

Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels

by Feng Li, Biyun Chen, Kun Xu, Jinfeng Wu, Weilin Song, Ian Bancroft, Andrea L. Harper, Martin Trick, Shengyi Liu, Guizhen Gao, Nian Wang, Guixin Yan, Jiangwei Qiao, Jun Li, Hao Li, Xin Xiao, Tianyao Zhang, Xiaoming Wu - Nature Genetics , 2013
"... Association mapping can quickly and efficiently dissect complex agronomic traits. Rapeseed is one of the most economically important polyploid oil crops, although its genome sequence is not yet published. In this study, a recently developed 60K Brassica Infiniumw SNP array was used to analyse an ass ..."
Abstract - Cited by 25 (2 self) - Add to MetaCart
Association mapping can quickly and efficiently dissect complex agronomic traits. Rapeseed is one of the most economically important polyploid oil crops, although its genome sequence is not yet published. In this study, a recently developed 60K Brassica Infiniumw SNP array was used to analyse

Genomic Regions Identified by Overlapping Clusters of Nominally-Positive SNPs from Genome-Wide Studies of Alcohol and Illegal Substance Dependence

by Catherine Johnson, Tomas Drgon, Donna Walther, George R. Uhl
"... Declaring ‘‘replication’ ’ from results of genome wide association (GWA) studies is straightforward when major gene effects provide genome-wide significance for association of the same allele of the same SNP in each of multiple independent samples. However, such unambiguous replication is unlikely w ..."
Abstract - Cited by 5 (0 self) - Add to MetaCart
Declaring ‘‘replication’ ’ from results of genome wide association (GWA) studies is straightforward when major gene effects provide genome-wide significance for association of the same allele of the same SNP in each of multiple independent samples. However, such unambiguous replication is unlikely

Genome-Wide Maps of Circulating miRNA Biomarkers for

by Ulcerative Colitis, Radha Duttagupta, Sharon Dirienzo, Rong Jiang, Jessica Bowers, Jeremy Gollub, Jessica Kao, David Rudolph, Noor B. Dawany, Michael K. Showe, Tom Stamato, Robert C. Getts, Keith W. Jones
"... Inflammatory Bowel Disease – comprised of Crohn’s Disease and Ulcerative Colitis (UC)- is a complex, multi-factorial inflammatory disorder of the gastrointestinal tract. In this study we have explored the utility of naturally occurring circulating miRNAs as potential blood-based biomarkers for non-i ..."
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. Interestingly, comparison of the miRNA biomarker panel and genetic loci implicated in IBD through genome-wide

SEARCHING GENOME-WIDE DISEASE ASSOCIATION THROUGH SNP DATA by

by Xuan Guo, Xuan Guo, Under Direction, Yi Pan
"... Taking the advantage of the high-throughput Single Nucleotide Polymorphism (SNP) genotyping technology, Genome-Wide Association Studies (GWASs) are regarded holding promise for unravelling complex relationships between genotype and phenotype. GWASs aim to identify genetic variants associated with di ..."
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Taking the advantage of the high-throughput Single Nucleotide Polymorphism (SNP) genotyping technology, Genome-Wide Association Studies (GWASs) are regarded holding promise for unravelling complex relationships between genotype and phenotype. GWASs aim to identify genetic variants associated

A Genome-Wide Association Study of the Maize Hypersensitive Defense Response Identifies Genes That Cluster in Related Pathways

by Bode A. Olukolu, Guan-feng Wang, Vijay Vontimitta, Bala P. Venkata, Eep Marla, Jiabing Ji, Emma Gachomo, Kevin Chu, Adisu Negeri, Jacqueline Benson, Rebecca Nelson, Peter Bradbury, Dahlia Nielsen, James B. Holl, Peter J. Balint-kurti, Gurmukh Johal
"... Much remains unknown of molecular events controlling the plant hypersensitive defense response (HR), a rapid localized cell death that limits pathogen spread and is mediated by resistance (R-) genes. Genetic control of the HR is hard to quantify due to its microscopic and rapid nature. Natural modif ..."
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(QTL) using a linkage map based on more than 7000 single nucleotide polymorphisms (SNPs). Genome-wide association (GWA) analysis of 26.5 million SNPs was conducted after adjusting for background QTL. GWA identified associated SNPs that colocalized with 44 candidate genes. Thirty-six of these genes
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