Tools
Sorted by:
Try your query at:
 |
 |
 |
 |
 |
 |
Results 1 -
4 of
4
RESEARCH Open Access Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis
"... Background: Multiple sclerosis (MS) is a disease of central nervous system that causes the removal of fatty myelin sheath from axons of the brain and spinal cord. Autoimmunity plays an important role in this pathology outcome and body’s own immune system attacks on the myelin sheath causing the dama ..."
Abstract
- Add to MetaCart
conditions such as a breakdown of the mechanisms that regulate and allow peripheral tolerance should be involved. Conclusions: The presented model allows to capture the essential dynamics of relapsing-remitting MS despite its simplicity. It gave useful insights that support the hypothesis of a breakdown
reveals the intrinsic character of relapses in Multiple Sclerosis
"... Background: The relapsing-remitting dynamics is a hallmark of autoimmune diseases such as Multiple Sclerosis (MS). Although current understanding of both cellular and molecular mechanisms involved in the pathogenesis of autoimmune diseases is significant, how their activity generates this prototypic ..."
Abstract
- Add to MetaCart
and active lesions in the magnetic resonances studies in patients with Multiple Sclerosis. Our analysis shows that the weakness in this negative feedback between effector and regulatory T-cells, allows the immune system to generate the characteristic relapsing-remitting dynamics of autoimmune diseases,
The Journal of Immunology Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules
"... Autoreactive T cells represent a natural repertoire of T cells in both diseased patients and healthy individuals. The mechanisms regulating the function of these autoreactive T cells are still unknown. Ob1A12 is a myelin basic protein (MBP)-reactive Th cell clone derived from a patient with relapsin ..."
Abstract
- Add to MetaCart
with relapsing-remitting multiple sclerosis. Mice transgenic for this human TCR and DRA and DRB1*1501 chains develop spontaneous experimental autoimmune encephalomyelitis. The reactivity of Ob1A12 is reported to be restricted to recognition of MBP peptide 85–99 in the context of DRB1*1501. DRA/DRB1
Advances in Computational Methods for X-Ray Optics III, 92090A; References
"... Introduction and Objectives Transition metal concentrations in the central nervous system (CNS) are implicated in neurodegenerative diseases such as Alzheimer's, Parkinson's and Multiple Sclerosis. A common symptom of these diseases is demyelination, which is the degradation of the myelin ..."
Abstract
- Add to MetaCart
Introduction and Objectives Transition metal concentrations in the central nervous system (CNS) are implicated in neurodegenerative diseases such as Alzheimer's, Parkinson's and Multiple Sclerosis. A common symptom of these diseases is demyelination, which is the degradation
