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In vitro mimicry of CaMBrl tumor-associated antigen by synthetic oligosaccharides
"... 2To whom correspondence should be addressed The murine monoclonal antibody (Mab) MBrl, raised against the breast cancer cell line MCF7, recognizes a sac-charidic epitope overexpressed on a high percentage of hu-man breast, ovary, and lung carcinomas. This antigen was originally identified on the imm ..."
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on the immunogen as a globo-series glycosphingolipid with an H-Iike determinant at its termi-nus (globo-H). We report here the biological characteriza-tion of the entire globo-H hexasaccharide and five synthetic oligosaccharides representing fragments of the entire struc-ture and/or different anomeric
Research Article Functional TCR Retrieval from Single Antigen-Specific Human T Cells
"... The determination of the epitope specificity of disease-associated T-cell responses is relevant for the development of biomarkers and targeted immunotherapies against cancer, autoimmune, and infectious diseases. The lack of known T-cell epitopes and corresponding T-cell receptors (TCR) for novel ant ..."
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enables the rational development of immunotherapy strategies by providing antigen-specific TCRs and immunogenic epitopes. Cancer Immunol Res; 2(12); 1–15. 2014 AACR.
Sophistication of foldamer form and function in vitro and in vivo This review comes from a themed issue on Biopolymers Edited
, 2007
"... Advances in the foldamer field in recent years are as diverse as the backbones of which they are composed. Applications have ranged from cellular penetration and membrane disruption to discrete molecular recognition, while efforts to control the complex geometric shape of foldamers has entered the ..."
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-amino acids into a-peptides has been reviewed previously [28], but new work by Muller and co-workers [29] expands the idea to the incorporation of aza-b 3 -amino acids, which contain nitrogen in the backbone, into a model peptide that mimics a CD4 T cell epitope. These peptides were recognized by T cells
