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by Brett S Abrahams , Daniel H Geschwind
"... Autistic disorder is the most severe end of a group of neurodevelopmental disorders referred to as autism spectrum disorders (ASDs), which share the common feature of dysfunctional reciprocal social interaction. A meta-analysis of ASD prevalence rates suggests that approximately 37 in 10,000 indivi ..."
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understanding of the genetic factors underlying the ASDs. These approaches include whole-genome and pathway-based association studies, dense resequencing to identify Gene association studies a set of methods that is used to determine the correlation (positive or negative) between a defined genetic variant and a

Ankle injuries in basketball: injury rate and risk factors

by G D Mckay , P A Goldie , W R Payne , B W Oakes - British Journal of Sports Medicine , 2001
"... Abstract Objectives-To determine the rate of ankle injury and examine risk factors of ankle injuries in mainly recreational basketball players. Methods-Injury observers sat courtside to determine the occurrence of ankle injuries in basketball. Ankle injured players and a group of non-injured basket ..."
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fight careers of 30-50 fights before retirement, an order of magnitude less than that described in Corsellis' landmark study. Recent research in boxers has also suggested that CTE in boxers may be associated with a particular genetic predisposition. The apolipoprotein E e-4 gene (ApoE), a

Themed Issue: Translational Neuropharmacology -Using Appropriate Animal Models to Guide Clinical Drug Development Translational approaches to obsessive-compulsive disorder: from animal models to clinical treatment LINKED ARTICLES

by N A Fineberg , S R Chamberlain , E Hollander , V Boulougouris , T W Robbins , 2011
"... Obsessive-compulsive disorder (OCD) is characterized by obsessions (intrusive thoughts) and compulsions (repetitive ritualistic behaviours) leading to functional impairment. Accumulating evidence links these conditions with underlying dysregulation of fronto-striatal circuitry and monoamine systems ..."
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Abbreviations 5CSRTT, 5-choice serial reaction time test; 5-HT, serotonin; APA, American Psychiatric Association; BOLD, blood oxygen level-dependent; CS, conditioned stimulus; DBS, deep brain stimulation; DSM, Diagnostic and Statistical Manual; ELP, excessive lever presses; (f)MRI, (functional) magnetic
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